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Typically in any given year our scientists publish in excess of 600 research papers and reviews. Here we provide a selection of their research highlights. 'Highlight' papers are those led by Biomedicine Discovery Institute scientists and represent original research, published in the top journals in the field.

to March 2017

View featured publications by year

2017 | 2016 | 2015 | 2014

  2017
1 Dyson, J.M., S.E. Conduit, S.J Feeney, S. Hakim, T. DiTommaso, A.J. Fulcher, A. Sriratana, G. Ramm, K.A. Horan, R. Gurung, C. Wicking, I. Smyth, and C.A. MitchellINPP5E regulates phosphoinositide-dependent cilia transition zone function. J Cell Biol, 2017 216(1):247-263
2 Keller, A.N., S.B. Eckle, W. Xu, L. Liu, V.A. Hughes, J.Y. Mak, B.S. Meehan, T. Pediongco, R.W. Birkinshaw, Z. Chen, H. Wang, C. D'Souza, L. Kjer-Nielsen, N.A. Gherardin, D.I. GodfreyI, L. Kostenko, A.J. Corbett, A.W. Purcell, D.P. Fairlie, J. McCluskey, and J. Rossjohn, Drugs and drug-like molecules can modulate the function of mucosal-associated invariant T cells. Nat Immunol, 2017 Feb 6. doi: 10.1038/ni.3679 [Epub ahead of print] 
3Marino, E., J.L. Richards, K.H. McLeod, D. Stanley, Y.A. Yap, J. Knight, C. McKenzie, J. Kranich, A.C. Oliveira, F.J. Rossello, B. Krishnamurthy, C.M. Nefzger, L. Macia, A. Thorburn, A.G. Baxter, G. Morahan, L.H. Wong, J.M. Polo, R.J. Moore, T.J. Lockett, J.M. Clarke, D.L. Topping, L.C. Harrison, and C.R. Mackay, Gut microbial metabolites limit the frequency of autoimmune T cells and protect against type 1 diabetes. Nat Immunol, 2017. doi: 10.1038/ni.3713
4 Padman, B.S., T.N. Nguyen, and M. Lazarou, Autophagosome formation and cargo sequestration in the absence of LC3/GABARAPs. Autophagy, 2017 Feb 6:0. doi: 10.1080/15548627.2017.1281492
5 Pymm, P., P.T Illing, S.H. Ramarathinam, G.M. O'Connor, V.A. Hughes, C. Hitchen, D.A. Price, B.K. Ho, D.W. McVicar, A.G. Brooks, A.W. Purcell, J. Rossjohn, and J.P. VivianMHC-I peptides get out of the groove and enable a novel mechanism of HIV-1 escape. Nat Struct Mol Biol, 2017 Feb 20. doi: 10.1038/nsmb.3381 [Epub ahead of print]
6 Singh, R.R., V. Sajeesh, L.C. Booth, Z. McArdle, C.N. May, G.A. Head, K.M. Moritz, M.P. Schlaich, and K.M. DentonCatheter-Based Renal Denervation Exacerbates Blood Pressure Fall During Hemorrhage. J Am Coll Cardiol, 2017 69(8):951-964
7Wang, H., L. Feng, G.I. Webb, L. Kurgan, J. Song, and D. Lin, Critical evaluation of bioinformatics tools for the prediction of protein crystallization propensity. Briefings in Bioinformatics, 2017, doi:10.1093/bib/bbx018. [Epub ahead of print]
8Wang, X., K.J. Goodrich, A.R. Gooding, H. Naeem, S. Archer, R.D. Paucek, D.T. Youmans, T.R. Cech, and C. Davidovich, Targeting of Polycomb Repressive Complex 2 to RNA by Short Repeats of Consecutive Guanines. Mol Cell, 2017. 65(6): p. 1056-1067 e5.
9 Waris, S., S.M. García-Mauriño, A. Sivakumaran, S.A Beckham, F.E Loughlin, M. Gorospe, I. Díaz-Moreno, M.C. Wilce, and J.A. WilceTIA-1 RRM23 binding and recognition of target oligonucleotides. Nucleic Acids Res, 2017 Feb 10. doi: 10.1093/nar/gkx102
  2016
1 Adhikari, D., K. Busayavalasa, J. Zhang, M. Hu, S. Risal, M.B. Bayazit, M. Singh, M.K. Diril, P. Kaldis, and K. Liu, Inhibitory phosphorylation of Cdk1 mediates prolonged prophase I arrest in female germ cells and is essential for female reproductive lifespan. Cell Res, 2016 26(11):1212-1225
2An, Y., J. Wang, C. Li, A. Leier, T. Marquez-Lago, J. Wilksch, Y. Zhang, G. I. Webb, J. Song and T. Lithgow, Comprehensive assessment and performance improvement of effector protein predictors for bacterial secretion systems III, IV and VI. Brief Bioinform, 2016 Oct 24. doi: 10.1093/bib/bbw100
3 Ando, A., D. Smallwood, M. McMahon, L. Irving, S.B. Mazzone and M.J. Farrell, Neural correlates of cough hypersensitivity in humans: evidence for central sensitisation and dysfunctional inhibitory control. Thorax, 2016. 71(4): p. 323-329 Category: Respiratory System Impact Factor: 8.121 Ranking: 4/58
4Archer S.K.,N.E. Shirokikh,T.H. Beilharz, and T. Preiss, Dynamics of ribosome scanning and recycling revealed by translation complex profiling. Nature 535, 570–574
5 Atapattu, L., N. Saha, C. Chheang, M.F. Eissman, K. Xu, M.E. Vail, L. Hii, C. Llerena, Z. Liu, K. Horvay, H.E. Abud, U. Kusebauch, R.L. Moritz, B.S. Ding, Z. Cao, S. Rafii, M. Ernst, A.M. Scott, D.B. Nikolov, M. Lackmann, and P.W. JanesAn activated form of ADAM10 is tumor selective and regulates cancer stem-like cells and tumor growth. J Exp Med, 2016 213(9):1741-57
6 Bertram, J.F., S.L. Goldstein, L. Pape, F. Schaefer, R.C. Shroff and B.A. Warady, Kidney disease in children: latest advances and remaining challenges. Nat Rev Nephrol, 2016. 12(3): p. 182-191 Category: Urology & Nephrology Impact Factor: 9.463 Ranking: 2/77
7 Bhuiyan, M.S., F. Ellett, G.L. Murray, X. Kostoulias, G.M. Cerqueira, K.E. Schulze, M.H. Mahamad Maifiah, J. Li, D.J. Creek, G.J Lieschke, and A.Y. Peleg, Acinetobacter baumannii phenylacetic acid metabolism influences infection outcome through a direct effect on neutrophil chemotaxis. Proc Natl Acad Sci USA, 2016 113(34):9599-604 
8 Dudkina, N.V., B.A. Spicer, C.F. Reboul, P.J. Conroy, N. Lukoyanova, H. Elmlund, R.H. Law, S.M. Ekkel, S.C. Kondos, R.J. Goode, G. Ramm, J.C. Whisstock, H.R. Saibil and M.A. Dunstone, Structure of the poly-C9 component of the complement membrane attack complex. Nat Commun, 2016. 7: p. 1-6 Category: Multidisciplinary Sciences Impact Factor: 11.329 Ranking: 3/63
9 Fernandez-Ruiz, D., W.Y. Ng, L.E. Holz, J.Z. Ma, A. Zaid, Y.C. Wong, L.S. Lau, V. Mollard, A. Cozijnsen, N. Collins, J. Li, G.M. Davey, Y. Kato, S. Devi, R. Skandari, M. Pauley, J.H. Manton, D.I. Godfrey, A. Braun, S.S. Tay, P.S. Tan, D.G. Bowen, F. Koch-Nolte, B. Rissiek, F.R. Carbone, B.S. Crabb, M. Lahoud, I.A. Cockburn, S.N. Mueller, P. Bertolino, G.I. McFadden, I. Caminschi, W.R. Heath, Liver-Resident Memory CD8+ T Cells Form a Front-Line Defense against Malaria Liver-Stage Infection. Immunity, 2016 45(4):889-902
10 Gherardin, N.A., A.N. Keller, R.E. Woolley, J. Le Nours, D.S. Ritchie, P.J. Neeson, R.W. Birkinshaw, S.B. Eckle, J.N. Waddington, L. Liu, D.P. Fairlie, A.P. Uldrich, D.G. Pellicci, J. McCluskey, D.I. Godfrey and J. Rossjohn, Diversity of T Cells Restricted by the MHC Class I-Related Molecule MR1 Facilitates Differential Antigen Recognition. Immunity, 2016. 44(1): p. 32-45 Category: Immunology Impact Factor: 24.082 Ranking: 3/150
11 Gras, S., J. Chadderton, C.M. Del Campo, C. Farenc, F. Wiede, T.M. Josephs, X.Y. Sng, M. Mirams, K.A. Watson, T. Tiganis, K.M. Quinn, J. Rossjohn, and N.L. La GrutaReversed T Cell Receptor Docking on a Major Histocompatibility Class I Complex Limits Involvement in the Immune Response. Immunity, 2016 45(4):749-760
12 Gras, S., I. Van Rhijn, A. Shahine, T.Y. Cheng, M. Bhati, L.L. Tan, H. Halim, K.D. Tuttle, L. Gapin, J. Le Nours, D.B. Moody, and J. RossjohnT cell receptor recognition of CD1b presenting a mycobacterial glycolipid. Nat Commun, 2016 7:13257
13 He, J., X. Zhang, Y. Wei, X. Sun, Y. Chen, J. Deng, Y. Jin, Y. Gan, X. Hu, R. Jia, C. Xu, Z. Hou, Y.A. Leong, L. Zhu, J. Feng, Y. An, Y. Jia, C. Li, X. Liu, H. Ye, L. Ren, R. Li, H. Yao, Y. Li, S. Chen, X. Zhang, Y. Su, J. Guo, N. Shen, E.F. Morand, D. Yu, and Z. Li, Low-dose interleukin-2 treatment selectively modulates CD4(+) T cell subsets in patients with systemic lupus erythematosus. Nat Med, 2016 22(9):991-3
14 Hossain, M.A., M. Kocan, S.T. Yao, S.G. Royce, V.B. Nair, C. Siwek, N.A. Patil, I.P. Harrison, K.J. Rosengren, S. Selemidis, R.J. Summers, J.D. Wade, R.A.D. Bathgate and C.S. Samuel, A single-chain derivative of the relaxin hormone is a functionally selective agonist of the G protein-coupled receptor, RXFP1. Chem Sci, 2016. 7(6): p. 3805-3819 Category: Chemistry Multidisciplinary Impact Factor: 9.155 Ranking: 14 /163
15 Jore, M.M., S. Johnson, D. Sheppard, N.M. Barber, Y.I. Li, M.A. Nunn, H. Elmlund and S.M. Lea, Structural basis for therapeutic inhibition of complement C5. Nat Struct Mol Biol, 2016. 23(5): p. 378-386 Category: Biochemistry & Molecular Biology Impact Factor: 13.338 Ranking: 6/289
16 Juozaityte, V., D. Pladevall-Morera, A. Podolska, S. Nørgaard, B. Neumann, and R. Pocock, The ETS-5 transcription factor regulates activity states in Caenorhabditis elegans by controlling satiety. Proc Natl Acad Sci USA, 2017 Feb 13. pii: 201610673. doi: 10.1073/pnas.1610673114. [Epub ahead of print]
17 Kim, J.H., Y. Hu, T. Yongqing, J. Kim, V.A. Hughes, J. Le Nours, E.A. Marquez, A.W. Purcell, Q. Wan, M. Sugita, J. Rossjohn, and F. Winau, CD1a on Langerhans cells controls inflammatory skin disease. Nat Immunol, 2016 17(10):1159-66
18 Le Nours, J., T. Praveena, D.G. Pellicci, N.A. Gherardin, F.J. Ross, R.T. Lim, G.S. Besra, S. Keshipeddy, S.K. Richardson, A.R. Howell, S. Gras, D.I. Godfrey, J. Rossjohn and A.P. Uldrich, Atypical natural killer T-cell receptor recognition of CD1d-lipid antigens. Nat Commun, 2016. 7(Article # 10570): p. 1-14 Category: Multidisciplinary Sciences Impact Factor: 11.329 Ranking: 3/63
19 Leong, Y.A., Y. Chen, H.S. Ong, D. Wu, K. Man, C. Deleage, M. Minnich, B.J. Meckiff, Y. Wei, Z. Hou, D. Zotos, K.A. Fenix, A. Atnerkar, S. Preston, J.G. Chipman, G.J. Beilman, C.C. Allison, L. Sun, P. Wang, J. Xu, T.G. Toe, H.K Lu, Y. Tao, U. Palendira, A.L. Dent, A.L. Landay, M. Pellegrini, I. Comerford, S.R. McColl, T.W. Schacker, H.M. Long, J.D. Estes, M. Busslinger, G.T. Belz, S.R. Lewin, A. Kallies, and D. YuCXCR5(+) follicular cytotoxic T cells control viral infection in B cell follicles. Nat Immunol, 2016 17(10):1187-96
20 McWilliam, H.E., S.B. Eckle, A. Theodossis, L. Liu, Z. Chen, J.M. Wubben, D.P. Fairlie, R.A. Strugnell, J.D. Mintern, J. McCluskey, J. Rossjohn and J.A. Villadangos, The intracellular pathway for the presentation of vitamin B-related antigens by the antigen-presenting molecule MR1. Nat Immunol, 2016. 17(5): p. 531-537 Category: Immunology Impact Factor: 19.381 Ranking: 4/150
21 Marques, F.Z., E.M. Nelson, P.Y. Chu, D. Horlock, A. Fiedler, M. Ziemann, J.K. Tan, S. Kuruppu, N.W. Rajapakse, A. El-Osta, C.R Mackay and D.M. Kaye, High Fibre Diet and Acetate Supplementation Change the Gut Microbiota and Prevent the Development of Hypertension and Heart Failure in DOCA-Salt Hypertensive Mice. Circulation, 2016, Dec 7. pii: CIRCULATIONAHA.116.024545. [Epub ahead of print]
22 Nguyen, T.N., B.S. Padman, J. Usher, V. Oorschot, G. Ramm, and M. LazarouAtg8 family LC3/GABARAP proteins are crucial for autophagosome-lysosome fusion but not autophagosome formation during PINK1/Parkin mitophagy and starvation. J Cell Biol, 2016 215(6):857-874
23 Nichols, A.L., E. Meelkop, C. Linton, R. Giordano-Santini, R.K. Sullivan, A. Donato, C. Nolan, D.H. Hall, D. Xue, B. Neumann and M.A. Hilliard, The Apoptotic Engulfment Machinery Regulates Axonal Degeneration in C. elegans Neurons. Cell Rep, 2016. 14(7): p. 1673-1683 Category: Cell Biology Impact Factor: 8.122 Ranking: 26/187
24 Oudhoff, M.J., M.J. Braam, S.A. Freeman, D. Wong, D.G. Rattray, J. Wang, F. Antignano, K. Snyder, I. Refaeli, M.R. Hughes, K.M. McNagny, M.R. Gold, C.H. Arrowsmith, T. Sato, F.M. Rossi, J.H. Tatlock, D.R. Owen, P.J. Brown and C. Zaph, SETD7 Controls Intestinal Regeneration and Tumorigenesis by Regulating Wnt/beta-Catenin and Hippo/YAP Signaling. Dev Cell, 2016. 37(1): p. 47-57 Category: Developmental Biology Impact Factor: 9.338 Ranking: 3/41
25 Pageon, S.V., T. Tabarin, Y. Yamamoto, Y. Ma, J.S. Bridgeman, A. Cohnen, C. Benzing, Y. Gao, M.D. Crowther, K. Tungatt, G. Dolton, A.K. Sewell, D.A. Price, O. Acuto, R.G. Parton, J.J. Gooding, J. Rossy, J. Rossjohn, and K. Gaus, Functional role of T-cell receptor nanoclusters in signal initiation and antigen discrimination. Proc Natl Acad Sci
USA, 2016 113(37):E5454-63
26 Peschke, M., K. Haslinger, C. Brieke, J. Reinstein and M.J. Cryle, Regulation of the P450 Oxygenation Cascade Involved in Glycopeptide Antibiotic Biosynthesis. J Am Chem Soc, 2016. 138(21): p. 6746-6753 Category: Chemistry, Multidisciplinary Impact Factor: 13.038 Ranking: 10/163
27 Puelles, V.G., J.W. van der Wolde, K.E. Schulze, K.M. Short, M.N. Wong, J.G. Bensley, L.A. Cullen-McEwen, G. Caruana, S.N. Hokke, J. Li, S.D. Firth, I.S. Harper, D.J. Nikolic-Paterson and J.F. Bertram, Validation of a Three-Dimensional Method for Counting and Sizing Podocytes in Whole Glomeruli. J Am Soc Nephrol, 2016. E-pub: p. 1-10 Category: Urology & Nephrology Impact Factor: 8.491 Ranking: 3/77
28 Rackham, O.J., J. Firas, H. Fang, M.E. Oates, M.L. Holmes, A.S. Knaupp, F. Consortium, H. Suzuki, C.M. Nefzger, C.O. Daub, J.W. Shin, E. Petretto, A.R. Forrest, Y. Hayashizaki, J.M. Polo and J. Gough, A predictive computational framework for direct reprogramming between human cell types. Nat Genet, 2016. 48(3): p. 331-335 Category: Genetics & Heredity Impact Factor: 31.616 Ranking: 2/165
29 Sarker, S., M.C. Terrón, Y. Khandokar, D. Aragão, J.M. Hardy, M. Radjainia, M. Jiménez-Zaragoza, P.J. de Pablo, F. Coulibaly, D. Luque, S.R. Raidal, and J.K. Forwood, Structural insights into the assembly and regulation of distinct viral capsid complexes. Nat Commun, 2016 7:13014
30 Saunders, P.M., P. Pymm, G. Pietra, V.A. Hughes, C. Hitchen, G.M. O'Connor, F. Loiacono, J. Widjaja, D.A. Price, M. Falco, M.C. Mingari, L. Moretta, D.W. McVicar, J. Rossjohn, A.G. Brooks and J.P. Vivian, Killer cell immunoglobulin-like receptor 3DL1 polymorphism defines distinct hierarchies of HLA class I recognition. J Exp Med, 2016. 213(5): p. 791-807 Category: Immunology Impact Factor: 11.240 Ranking: 7/150
31 Short, K.M. and I.M. Smyth, The contribution of branching morphogenesis to kidney development and disease. Nat Rev Nephrol, 2016 12(12): 754-767
32 Speir, M., K.E. Lawlor, S.P. Glaser, G. Abraham, S. Chow, A. Vogrin, K.E. Schulze, R. Schuelein, L.A. O'Reilly, K. Mason, E.L. Hartland, T. Lithgow, A. Strasser, G. Lessene, D.C.S. Huang, J.E. Vince and T. Naderer, Eliminating Legionella by inhibiting BCL-XL to induce macrophage apoptosis. Nature Micro, 2016. 1: p. 1-9
33 Stroud, D.A., E.E. Surgenor, L.E. Formosa, B. Reljic, A.E. Frazier, M.G. Dibley, L.D. Osellame, T. Stait, T.H. Beilharz, D.R. Thorburn, A. Salim, M.T. Ryan, Accessory subunits are integral for assembly and function of human mitochondrial complex I. Nature, 2016 538(7623):123-126 
34 Stubenrauch, C., M.J. Belousoff, I.D. Hay, H.H. Shen, J. Lillington, K.L. Tuck, K.M. Peters, M.D. Phan, A.W. Lo, M.A. Schembri, R.A. Strugnell, G. Waksman and T. Lithgow, Effective assembly of fimbriae in Escherichia coli depends on the translocation assembly module nanomachine. Nature Micro, 2016. 1: p. 16064
35 Swaminathan, A. and T.H. Beilharz, Epitope-tagged yeast strains reveal promoter driven changes to 3'-end formation and convergent antisense-transcription from common 3' UTRs. Nucleic Acids Res, 2016. 44(1): p. 377-386 Category: Biochemistry & Molecular Biology Impact Factor: 9.202 Ranking: 18/289
36 Taylor, R.A., M. Fraser, J. Livingstone, S.M. Espiritu, H. Thorne, V. Huang, W. Lo, Y.J. Shiah, T.N. Yamaguchi, A. Sliwinski, S. Horsburgh, A. Meng, L.E. Heisler, N. Yu, F. Yousif, M. Papargiris, M.G. Lawrence, L. Timms, D.G. Murphy, M. Frydenberg, J.F. Hopkins, D. Bolton, D. Clouston, J.D. McPherson, T. van der Kwast, P.C. Boutros, G.P. Risbridger, and R.G. Bristow, Germline BRCA2 mutations drive prostate cancers with distinct evolutionary trajectories. Nat Commun, 2017 8:13671 
37 Tullett, K.M., I.M.L. Rojas, Y. Minoda, P.S. Tan, J.G. Zhang, C. Smith, R.Khanna, K. Shortman, I. Caminschi, M.H. Lahoud, and K.J. Radford, Targeting CLEC9A delivers antigen to human CD141+ DC for CD4+ and CD8+T cell recognition. JCI Insight, 2016. 1(7): e87102
38 Valkenburg, S.A., T.M. Josephs, E.B. Clemens, E.J. Grant, T.H. Nguyen, G.C. Wang, D.A. Price, A. Miller, S.Y. Tong, P.G. Thomas, P.C. Doherty, J. Rossjohn, S. Gras and K. Kedzierska, Molecular basis for universal HLA-A*0201-restricted CD8+ T-cell immunity against influenza viruses. Proc Natl Acad Sci U S A, 2016. 113(16): p. 4440-4445 Category: Multidisciplinary Sciences Impact Factor: 9.423 Ranking: 4/63
  2015
1

Atkinson, S.C., J.S. Armistead, D.K. Mathias, M.M. Sandeu, D. Tao, N. Borhani-Dizaji, B.B. Tarimo, I. Morlais, R.R. Dinglasan and N.A. Borg, The Anopheles-midgut APN1 structure reveals a new malaria transmission-blocking vaccine epitope. Nat Struct     Mol     Biol,     2015. E-pub:     p.     1-9     Category:     Biochemistry     &     Molecular     Biology Impact Factor: 13.309 Ranking:     7/289.

2

Beringer, D.X., F.S. Kleijwegt, F. Wiede, A.R. van der Slik, K.L. Loh, J. Petersen, N.L. Dudek, G. Duinkerken, S. Laban, A. Joosten, J.P. Vivian, Z. Chen, A.P. Uldrich, D.I. Godfrey, J. McCluskey, D.A. Price,     K.J.     Radford,     A.W.     Purcell,     T.     Nikolic, H.H. Reid, T. Tiganis,     B.O.     Roep     and J. Rossjohn, T cell receptor reversed polarity recognition of a self-antigen major histocompatibility complex. Nat Immunol, 2015. E-pub: p. 1-11 Category: Immunology Impact Factor: 20.004 Ranking: 4/148.

3

Birkinshaw, R.W., D.G. Pellicci, T.Y. Cheng, A.N. Keller, M. Sandoval-Romero, S. Gras, A. de Jong, A.P. Uldrich, D.B. Moody, D.I. Godfrey and J. Rossjohn, {alphabeta} T cell antigen receptor recognition of CD1a presenting self lipid ligands. Nat Immunol, 2015. 16(3): p. 258-266 Category: Immunology Impact Factor: 20.004 Ranking: 4/148.

4Chang, C.C., B.T. Tey, J. Song, and R.N. Ramanan. Towards more accurate prediction of protein folding rates: a review of the existing Web-based bioinformatics approaches. Briefings in Bioinformatics. 2015, 16(2): 314-324.  Category: Biochemical Research Methods Impact Factor: 9.617 Ranking:     3/79.
5

Chang, F.T., F.L. Chan, R.M. JD, M. Udugama, L. Mayne, P. Collas, J.R. Mann and L.H. Wong, CHK1-driven histone H3.3 serine 31 phosphorylation is important for chromatin maintenance and cell survival in human ALT cancer cells. Nucleic Acids Res, 2015. 43(5): p. 2603-2614 Category: Biochemistry & Molecular Biology Impact Factor: 9.112 Ranking: 20/289.

6

Chen, Z., Y. Zhou, Z. Zhang and J. Song, Towards more accurate prediction of ubiquitination sites: a comprehensive review of current methods, tools and features. Brief Bioinform, 2015. 16(4): p. 640-657 Category: Biochemical Research Methods Impact Factor: 9.617 Ranking:     3/79.

7

Chiu, E., M. Hijnen, R.D. Bunker, M. Boudes, C. Rajendran, K. Aizel, V. Olieric, C. Schulze-Briese, W. Mitsuhashi, V. Young, V.K. Ward, M. Bergoin, P. Metcalf and F. Coulibaly, Structural basis for the enhancement of virulence by viral spindles and their in vivo crystallization. Proc Natl Acad Sci U S A, 2015. 112(13): p. 3973-3978 Category: Multidisciplinary Sciences Impact Factor: 9.674 Ranking: 4/56.

8

Davies, E.M., A.M. Kong, A. Tan, R. Gurung, A. Sriratana, P.E. Bukczynska, L.M. Ooms, C.A. McLean, T. Tiganis and C.A. Mitchell, Differential SKIP expression in PTEN-deficient glioblastoma regulates cellular proliferation and migration. Oncogene, 2014. 34(28): p. 3711-3727 Category: Oncology Impact Factor: 8.459 Ranking: 13/211.

9

Dodd, G.T., S. Decherf, K. Loh, S.E. Simonds, F. Wiede, E. Balland, T.L. Merry, H. Munzberg, Z.Y. Zhang, B.B. Kahn, B.G. Neel, K.K. Bence, Z.B. Andrews, M.A. Cowley and T. Tiganis, Leptin and insulin act on POMC neurons to promote the browning of white fat. Cell, 2015. 160(1-2): p. 88-104 Category: Biochemistry & Molecular Biology Impact Factor: 32.242 Ranking: 1/289.

10

Doerig, C., J.C. Rayner, A. Scherf and A.B. Tobin, Post-translational protein modifications in malaria parasites. Nat Rev Microbiol, 2015. 13(3): p. 160-172 Category: Microbiology Impact Factor: 23.574 Ranking: 1/119.

11

Hobbs, R.M., H.M. La, J.A. Makela, T. Kobayashi, T. Noda and P.P. Pandolfi, Distinct germline progenitor subsets defined through Tsc2-mTORC1 signaling. EMBO Rep, 2015. 16(4): p. 467-480 Category: Biochemistry     &     Molecular     Biology Impact Factor: 9.055 Ranking:     22/289.

12

Horvay, K., T. Jarde, F. Casagranda, V.M. Perreau, K. Haigh, C.M. Nefzger, R. Akhtar, T. Gridley, G. Berx, J.J. Haigh, N. Barker, J.M. Polo, G.R. Hime and H.E. Abud, Snai1 regulates cell lineage allocation and stem cell maintenance in the mouse intestinal epithelium. EMBO J, 2015. 34(10): p. 1319-1335 Category: Biochemistry & Molecular Biology Impact Factor: 10.434 Ranking: 11/289.

13

Lankadeva, Y.R., R.R. Singh, K.M. Moritz, H.C. Parkington, K.M. Denton and M. Tare, Renal Dysfunction is Associated with a Reduced Contribution of Nitric Oxide and Enhanced Vasoconstriction Following a Congenital Renal Mass Reduction in Sheep. Circulation, 2015. 131(3): p. 280-288 Category: Peripheral Vascular Disease Impact Factor: 14.430 Ranking: 1/60.

14

Lazarou, M., D.A. Sliter, L.A. Kane, S.A. Sarraf, C. Wang, J.L. Burman, D.P. Sideris, A.I. Fogel and R.J. Youle, The ubiquitin kinase PINK1 recruits autophagy receptors to induce mitophagy. Nature, 2015. 524(7565): p. 309-314 Category: Multidisciplinary     Sciences Impact Factor: 41.456 Ranking:     1/57.

15

Li, C., C. Ching Han Chang, J. Nagel, B.T. Porebski, M. Hayashida, T. Akutsu, J. Song and A.M. Buckle, Critical evaluation of in silico methods for prediction of coiled-coil domains in proteins. Brief Bioinform, 2015. E-pub: p. 1-13 Category: Biochemical Research Methods Impact Factor: 9.617 Ranking:     3/79.

16

Lukoyanova, N., S.C. Kondos, I. Farabella, R.H. Law, C.F. Reboul, T.T. Caradoc-Davies, B.A. Spicer, O. Kleifeld, D.A. Traore, S.M. Ekkel, I. Voskoboinik, J.A. Trapani, T. Hatfaludi,     K.     Oliver,     E.M.     Hotze,     R.K.     Tweten, J.C. Whisstock,     M.     Topf,     H.R.     Saibil     and M.A. Dunstone, Conformational Changes during Pore Formation by the Perforin-Related Protein Pleurotolysin. PLoS Biol, 2015. 13(2): p. e1002049.1-15 Category:     Biochemistry     &     Molecular     Biology Impact Factor: 9.343 Ranking:     17/289.

17

Macia, L., J. Tan, A.T. Vieira, K. Leach, D. Stanley, S. Luong, M. Maruya, C. Ian McKenzie, A. Hijikata, C. Wong, L. Binge, A.N. Thorburn, N. Chevalier, C. Ang, E. Marino, R. Robert,     S.     Offermanns,     M.M.     Teixeira, R.J. Moore,     R.A.     Flavell,     S.     Fagarasan     and C.R. Mackay, Metabolite-sensing receptors GPR43 and GPR109A facilitate dietary fibre-induced gut homeostasis through regulation of the inflammasome. Nat Commun, 2015. 6(Article:     6734)Category:     Multidisciplinary     Sciences Impact Factor: 11.470 Ranking:     3/56.

18

Mansouri, F.A., M.J. Buckley, M. Mahboubi and K. Tanaka, Behavioral consequences of selective damage to frontal pole and posterior cingulate cortices. Proc Natl Acad Sci U S A, 2015. 112(29): p. E3940-3949 Category: Multidisciplinary Sciences Impact Factor: 9.674 Ranking:     4/56.

19

Ooms, L.M., L.C. Binge, E.M. Davies, P. Rahman, J.R. Conway, R. Gurung, D.T. Ferguson, A. Papa, C.G. Fedele, J.L. Vieusseux, R.C. Chai,     F.     Koentgen, J.T. Price, T. Tiganis,     P.     Timpson,     C.A.     McLean     and C.A. Mitchell, The Inositol Polyphosphate 5-Phosphatase PIPP Regulates AKT1-Dependent Breast Cancer Growth and Metastasis. Cancer Cell, 2015. 28(2):     p.     155-169     Category:     Oncology Impact Factor: 23.523 Ranking:     4/184.

20

Puelles, V.G., R.N. Douglas-Denton, L.A. Cullen-McEwen, J. Li, M.D. Hughson, W.E. Hoy, P.G. Kerr and J.F. Bertram, Podocyte Number in Children and Adults: Associations with Glomerular Size and Numbers of Other Glomerular Resident Cells. J Am Soc Nephrol, 2015. E-pub: p. 1-XX Category: Urology & Nephrology Impact Factor: 9.343 Ranking: 3/76.

21

Qu, X., M. Jiang, Y.B. Sun, X. Jiang, P. Fu, Y. Ren, D. Wang, L. Dai, G. Caruana, J.F. Bertram, D.J. Nikolic-Paterson and J. Li, The Smad3/Smad4/CDK9 complex promotes renal fibrosis in mice with unilateral ureteral obstruction. Kidney Int, 2015. E-pub: p. 1-13 Category: Urology & Nephrology Impact Factor: 8.563 Ranking: 4/76.

22

Risbridger, G.P., R.A. Taylor, D. Clouston, A. Sliwinski, H. Thorne, S. Hunter, J. Li, G. Mitchell, D. Murphy, M. Frydenberg, D. Pook, J. Pedersen, R. Toivanen, H. Wang, M. Papargiris, M.G. Lawrence and D.M. Bolton, Patient-derived Xenografts Reveal that Intraductal Carcinoma of the Prostate Is a Prominent Pathology in BRCA2 Mutation Carriers with Prostate Cancer and Correlates with Poor Prognosis. Eur Urol, 2015. 67(3): p. 496-503 Category: Urology     &     Nephrology Impact Factor: 13.938 Ranking:     1/76.

23

Shiota, T., K. Imai, J. Qiu, V.L. Hewitt, K. Tan, H.H. Shen, N. Sakiyama, Y. Fukasawa, S. Hayat, M. Kamiya, A. Elofsson, K. Tomii, P. Horton, N. Wiedemann, N. Pfanner, T. Lithgow and T. Endo, RESEARCH REPORT: Molecular architecture of the active mitochondrial protein gate. Science, 2015. 349(6255): p. 1544-1548 Category: Multidisciplinary Sciences Impact Factor: 33.611 Ranking: 2/56.

24

Stone, M.J. and R.J. Payne, Homogeneous Sulfopeptides and Sulfoproteins: Synthetic Approaches and Applications To Characterize the Effects of Tyrosine Sulfation on Biochemical Function. Acc Chem Res, 2015. 48(8): p. 2251-2261 Category: Chemistry,     Multidisciplinary Impact Factor: 22.323 Ranking:     4/157.

  2014
1

Bird, C.H., M.E. Christensen, M.S. Mangan, M.D. Prakash, K.A. Sedelies, M.J. Smyth, I. Harper, N.J. Waterhouse and P.I. Bird, The granzyme B-Serpinb9 axis controls the fate of lymphocytes after lysosomal stress. Cell Death Differ, 2014. 21: p. 876-887 Category: Biochemistry & Molecular Biology Impact Factor: 8.385 Ranking: 25/291.

2

Borg, M.L., M. Lemus, A. Reichenbach, A. Selathurai, B.J. Oldfield, Z.B. Andrews and M.J. Watt, Hypothalamic neurogenesis is not required for the improved insulin sensitivity following exercise training. Diabetes, 2014. 63(11): p. 3647-3658 Category: Endocrinology & Metabolism. Impact Factor: 8.474 Ranking: 6/123.

3

Boyd, A.W., P.F. Bartlett and M. Lackmann, Therapeutic targeting of EPH receptors and their ligands. Nat Rev Drug Discov, 2014. 13(1): p. 39-62 Category: Biotechnology & Applied Microbiology Impact Factor: 37.231 Ranking: 2/165.

4

Chow, B.S., M. Kocan, S. Bosnyak, M. Sarwar, B. Wigg, E.S. Jones, R.E. Widdop, R.J. Summers, R.A. Bathgate, T.D. Hewitson and C.S. Samuel, Relaxin requires the angiotensin II type 2 receptor to abrogate renal interstitial fibrosis. Kidney Int, 2014. 86(1): p. 75-85 Category: Urology & Nephrology Impact Factor: 8.520 Ranking: 3/75.

5

Corbett, A.J., S.B. Eckle, R.W. Birkinshaw, L. Liu, O. Patel, J. Mahony, Z. Chen, R. Reantragoon, B. Meehan, H. Cao, N.A. Williamson, R.A. Strugnell, D. Van Sinderen, J.Y. Mak, D.P. Fairlie, L. Kjer-Nielsen, J. Rossjohn and J. McCluskey, T-cell activation by transitory neo-antigens derived from distinct microbial pathways. Nature, 2014. 509: p. 361-365 Category: Multidisciplinary Sciences Impact Factor: 42.351 Ranking: 1/55.

6

DiTommaso, T., D.L. Cottle, H.B. Pearson, H. Schluter, P. Kaur, P.O. Humbert and I.M. Smyth, Keratin 76 is required for tight junction function and maintenance of the skin barrier. PLoS Genet, 2014. 10(10):     p.     e1004706.1-13     Category:     Genetics     &     Heredity Impact Factor: 8.167 Ranking:     14/165.

7

DiTommaso, T., L.K. Jones, D.L. Cottle, W.M.G. Program, A.K. Gerdin, V.E. Vancollie, F.M. Watt, R. Ramirez-Solis, A. Bradley, K.P. Steel, J.P. Sundberg, J.K. White and I.M. Smyth, Identification of genes important for cutaneous function revealed by a large scale reverse genetic screen in the mouse. PLoS Genet, 2014. 10(10): p. e1004705.1-12 Category: Genetics & Heredity Impact Factor: 8.167 Ranking: 14/165.

8

Eckle, S.B., R.W. Birkinshaw, L. Kostenko, A.J. Corbett, H.E. McWilliam, R. Reantragoon, Z. Chen, N.A. Gherardin, T. Beddoe, L. Liu, O. Patel, B. Meehan, D.P. Fairlie, J.A. Villadangos, D.I. Godfrey, L. Kjer-Nielsen, J. McCluskey and J. Rossjohn, A molecular basis underpinning the T cell receptor heterogeneity of mucosal-associated invariant T cells. J Exp Med, 2014. 211(8): p. 1585-1600 Category: Immunology impact Factor: 13.912 Ranking: 5/144.

9

Ellem, S.J., E.M. De-Juan-Pardo and G.P. Risbridger, In vitro modeling of the prostate cancer microenvironment. Adv Drug Deliv Rev, 2014. 79-80: p. 214-221 Category: Pharmacology & Pharmacy Impact Factor: 12.707 Ranking:     4/254.

10

Gurzov, E.N., M. Tran, M.A. Fernandez-Rojo, T.L. Merry, X. Zhang, Y. Xu, A. Fukushima, M.J. Waters, M.J. Watt, S. Andrikopoulos, B.G. Neel and T. Tiganis, Hepatic Oxidative Stress Promotes Insulin-STAT-5 Signaling and Obesity by Inactivating Protein Tyrosine Phosphatase N2. Cell Metab, 2014. 20(1): p. 85-102 Category: Cell Biology Impact Factor: 16.747 Ranking: 8/185.

11

Henstridge, M.A., T.K. Johnson, C.G. Warr and J.C. Whisstock, Trunk cleavage is essential for Drosophila terminal patterning and can occur independently of Torso-like. Nat Commun, 2014. 5: p. 3419.1-7 Category: Multidisciplinary     Sciences Impact Factor: 10.742 Ranking:     3/55.

12

Kass, I., D.E. Hoke, M.G. Costa, C.F. Reboul, B.T. Porebski, N.P. Cowieson, H. Leh, E. Pennacchietti, J. McCoey, O. Kleifeld, C. Borri Voltattorni, D. Langley, B. Roome, I.R. Mackay, D. Christ,     D.     Perahia,     M.     Buckle,     A.     Paiardini,     D.     De     Biase     and A.M. Buckle, Cofactor-dependent conformational heterogeneity of GAD65 and its role in autoimmunity and neurotransmitter homeostasis. Proc Natl Acad Sci U S A, 2014. 111(25): p. E2524-2529     Category:     Multidisciplinary     Sciences Impact Factor: 9.809 Ranking:     4/55.

13

Leyton, D.L., M.D. Johnson, R. Thapa, G.H. Huysmans, R.A. Dunstan, N. Celik, H.H. Shen, D. Loo, M.J. Belousoff, A.W. Purcell, I.R. Henderson, T. Beddoe, J. Rossjohn,     L.L.     Martin,     R.A.     Strugnell     and T. Lithgow, A mortise-tenon joint in the transmembrane domain modulates autotransporter assembly into bacterial outer membranes. Nat Commun, 2014. 5: p. 4239.1-11 Category: Multidisciplinary Sciences Impact Factor: 10.742 Ranking:     3/55.

14

Lieu, K.G., E.H. Shim, J. Wang, R.K. Lokareddy, T. Tao, G. Cingolani, G.P. Zambetti and D.A. Jans, The p53-induced factor Ei24 inhibits nuclear import through an importin beta-binding-like domain. J Cell Biol, 2014. 205(3):     p.     301-312     Category:     Cell     Biology Impact Factor: 9.688 Ranking:     21/185.

15

Nabti, I., P. Marangos, J. Bormann, N.R. Kudo and J. Carroll, Dual-mode regulation of the APC/C by CDK1 and MAPK controls meiosis I progression and fidelity. J Cell Biol, 2014. 204(6): p. 891-900 Category: Cell Biology Impact Factor: 9.688 Ranking: 21/185.

16

Parkington, H.C., J. Stevenson, M.A. Tonta, J. Paul, T. Butler, K. Maiti, E.C. Chan, P.M. Sheehan, S.P. Brennecke, H.A. Coleman and R. Smith, Diminished hERG K+ channel activity facilitates strong human labour contractions but is dysregulated in obese women. Nat Commun, 2014. 5(Article #4108): p. 1-8 Category: Multidisciplinary Sciences Impact Factor: 10.742 Ranking: 3/55.

17

Pellicci, D.G., A.P. Uldrich, J. Le Nours, F. Ross, E. Chabrol, S.B. Eckle, R. de Boer, R.T. Lim, K. McPherson, G. Besra, A.R. Howell, L. Moretta, J. McCluskey, M.H. Heemskerk, S. Gras, J. Rossjohn and D.I. Godfrey, The molecular bases of delta/alphabeta T cell-mediated antigen recognition. J Exp Med, 2014. 211(13): p. 2599-2615 Category: Immunology Impact Factor: 13.912 Ranking: 5/144.

18

Petersen, J., V. Montserrat, J.R. Mujico, K.L. Loh, D.X. Beringer, M. van Lummel, A. Thompson, M.L. Mearin, J. Schweizer, Y. Kooy-Winkelaar, J. van Bergen, J.W. Drijfhout, W.T. Kan, N.L. La Gruta, R.P. Anderson, H.H. Reid, F. Koning and J. Rossjohn, T-cell receptor recognition of HLA-DQ2-gliadin complexes associated with celiac disease. Nat Struct Mol Biol, 2014. 21(5): p. 480-490 Category: Biochemistry & Molecular Biology Impact Factor: 11.633 Ranking: 14/291.

19

Prakash, M.D., M.A. Munoz, R. Jain, P.L. Tong, A. Koskinen, M. Regner, O. Kleifeld, B. Ho, M. Olson, S.J. Turner, P. Mrass, W. Weninger and P.I. Bird, Granzyme B promotes cytotoxic lymphocyte transmigration via basement membrane remodeling. Immunity, 2014. 41(6): p. 960-972 Category: Immunology Impact Factor: 19.748 Ranking: 4/144.

20

Shen, H.H., D.L. Leyton, T. Shiota, M.J. Belousoff, N. Noinaj, J. Lu, S.A. Holt, K. Tan, J. Selkrig, C.T. Webb, S.K. Buchanan, L.L. Martin and T. Lithgow, Reconstitution of a nanomachine driving the assembly of proteins into bacterial outer membranes. Nat Commun, 2014. 5(5078): p. 1-10 Category: Multidisciplinary Sciences Impact Factor: 10.742 Ranking: 3/55.

21

Short, K.M., A.N. Combes, J. Lefevre, A.L. Ju, K.M. Georgas, T. Lamberton, O. Cairncross, B.A. Rumballe, A.P. McMahon, N.A. Hamilton, I.M. Smyth and M.H. Little, Global quantification of tissue dynamics in the developing mouse kidney. Dev Cell, 2014. 29(2):     p.     188-202     Category:     Cell     Biology Impact Factor: 10.366 Ranking:     17/185.

22

Simonds, S.E., J.T. Pryor, E. Ravussin, F.L. Greenway, R. Dileone, A.M. Allen, J. Bassi, J.K. Elmquist, J.M. Keogh, E. Henning, M.G. Myers, Jr., J. Licinio, R.D. Brown, P.J. Enriori, S. O'Rahilly, S.M. Sternson, K.L. Grove, D.C. Spanswick,     I.S.     Farooqi     and M.A. Cowley, Leptin mediates the increase in blood pressure associated with obesity. Cell, 2014. 159(6): p. 1404-1416 Category: Biochemistry & Molecular Biology Impact Factor: 33.116 Ranking: 1/291.

23

Teoh, S.S., J. Vieusseux, M. Prakash, S. Berkowicz, J. Luu, C.H. Bird, R.H. Law, C. Rosado, J.T. Price, J.C. Whisstock and P.I. Bird, Maspin is not required for embryonic development or tumour suppression. Nat Commun, 2014. 5: p. 3164.1-9 Category: Multidisciplinary Sciences Impact Factor: 10.742 Ranking: 3/55.

24

Vail, M.E., C. Murone, A. Tan, L. Hii, D. Abebe, P.W. Janes, F.T. Lee, M. Baer, V. Palath, C. Bebbington, G. Yarranton, C. Llerena, S. Garic, D. Abramson, G. Cartwright, A.M. Scott and M. Lackmann, Targeting EphA3 Inhibits Cancer Growth by Disrupting the Tumor Stromal Microenvironment. Cancer Res, 2014. 74(16): p. 4470-4481 Category: Oncology Impact Factor: 9.284 Ranking: 10/202.

25

Wiede, F., N.L. La Gruta and T. Tiganis, PTPN2 attenuates T-cell lymphopenia-induced proliferation. Nat Commun, 2014. 5: p. 3073.1-15 Category: Multidisciplinary Sciences Impact Factor: 10.742 Ranking: 3/55.