Inflammation and pain are conserved protective mechanisms that are essential for survival. Inflammation, characterised by acute changes in the circulatory and immune systems, protects against infection. Pain allows avoidance of damaging stimuli.
Dysregulated chronic inflammation underlies diseases of global relevance—such as cardiovascular disease, cancer, diabetes, obesity and autoimmune diseases—and can cause chronic pain. Chronic inflammation and pain are major causes of human suffering, yet are poorly understood.
DDB's studies seek to understand the basic mechanisms that control signalling of inflammation and pain, and determine whether defects in these regulatory mechanisms cause disease.
GPCR trafficking and regulatory complexes
pain, inflammation, neuropeptide receptors, protein trafficking and regulation, signal transduction
prostate, benign prostatic hyperplasia (BPH), lower urinary tract symptoms, smooth muscle, spontaneous activity, contractile activity, slow waves, metabolic and endocrine disorders, inflammation
Hidden regulatory centres
inflammation, immune system, moonlighting catalytic centres, serotonin receptors, chemical biology, gastrointestinal health, haplotypes
Enteric neurobiology and digestive disease
inflammation, colitis, neuroscience, enteric nervous system, pain, neuroimmune interaction, gastrointestinal physiology, glia, TRP channels