Drug permeability

Permeability across biological membranes is a key factor in the absorption and distribution of drugs. Poor permeability can arise due to a number of structural features, as well as membrane-based efflux mechanisms. This can lead to poor absorption across the gastrointestinal mucosa or poor distribution throughout the body.

CDCO offers in vitrocell-based methods to simulate gastrointestinal permeability and transporter interactions, and in vivo models to assess brain uptake.

Research platforms include:

  • in silico predictive methods
  • Caco-2 and MDCK cell culture models
  • PAMPA (parallel artificial membrane permeability assay)
  • in vivo brain-to-plasma ratio determination (rat/mouse)
  • brain binding assays (rat/mouse)