6 points, SCA Band 2, 0.125 EFTSL
Undergraduate - Unit
Refer to the specific census and withdrawal dates for the semester(s) in which this unit is offered.
- Second semester 2018 (On-campus)
This unit provides the conceptual and intellectual foundation for further studies in B Pharm Science (formulation stream) units in 3rd year. Broad areas covered include detailed study of chemical and physical stability in liquid and in solid pharmaceutical systems; overview of biotechnologically produced proteins, including their manufacture, characterization, stability and delivery; and a survey of the main pharmaceutical excipients.
On completion of the unit students will:
- Solve problems using standard methods for quantitative analysis of concentration-time profiles, to obtain degradation rate constants, half-lives and shelf-lives;
- Solve problems involving the physicochemical factors that influence reaction rates, especially the roles of temperature and acid-base equilibria;
- Describe the common mechanisms for chemical degradation of typical organic drugs and excipients, and their applicability to new situations, with emphasis on
- nucleophilic reactions
- free radical reactions
- Solve problems requiring application of methods for minimising the extent of degradation reactions, thus leading to increased life-times of formulated products;
- Identify the conditions under which the kinetics involved in oxidation, photochemical and solid state degradation reactions can be separated into simple and complex models;
- Describe the key physicochemical issues for therapeutic proteins, including formulation by lyophilisation;
- Describe a wide range of common pharmaceutical excipient types, their physicochemical properties and their roles in formulations.
Assessment will use a written examination (120mins; 60%); marked lab class reports (20%); written assignment (5%); in-semester testing 15%
Contact hours for on-campus students:
- Three lectures per week
- One workshop
- Eighteen hours of laboratory
- Three hours of directed study per week
See also Unit timetable information