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Chidgey Laboratory

Thymus Development, Ageing and T Cell Regeneration

Welcome to the Chidgey Lab

My laboratory investigates thymic epithelial stem cells, what induces their functional deterioration in young adults that leads to early thymus atrophy, and how to effectively regenerate thymus tissue to replenish a broad repertoire of T cells for immune recovery.

We're part of the Monash Biomedicine Discovery Institute, and a member of the Development & Stem CellsInfection & Immunity Program
and the Department of Anatomy and Developmental Biology.

Associate Professor Ann Chidgey

My global research connections, partners and funding can be viewed on my Monash Research Profile.

If you are a student interested in doing research in our lab, visit Supervisor Connect.

Click the links below to connect with me on ORCID and LinkedIn.

Our research

Thymic epithelial cells (TEC) provide most of the specialist functions required for the generation of self-tolerant T cells. However, the thymus begins degenerating from early in life, leading to a progressive decline in immune system function and susceptibility to infections and cancer. Our research programs investigate TEC development, the mechanisms behind TEC loss during ageing and ways in which the thymus can be functionally restored following damage by ageing, disease, chemotherapy and radiotherapy, to replenish a diverse T cell repertoire.

  • Characterising thymic epithelial stem cells and their niche.

  • Thymic epithelial stem cells in thymus ageing and repair following damage.

  • Generating 3D thymus organoids using defined biomatrices and growth factors.

Lab members

We are committed to excellence in research.

Publications

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News

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