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We investigate the role of an “unconventional” group of human immune cells in their ability to protect human body throughout life. The human immune system is a highly specialised network of cells, organs, receptors and soluble factors that protects the host from infection and cancer, while promoting normal function of the tissues in concert with the microbiome. The immune system uses lymphocytes to generate immunological memory responses to numerous challenges throughout life. Three lineages of lymphocytes have co-evolved over the last 550 million years: B cells, ɑβ T cells and γδ T cells. While conventional ɑβ T cells and B cells have been the subject of significant scientific research, leading to life changing breakthroughs in vaccination and cancer treatment, our group studies poorly understood subsets of unconventional T cells: γδ T cells and mucosal associated invariant T (MAIT) cells.
We use cutting-edge approaches, supported by Monash Platform Technologies, that includes the application of multi parameter flow cytometry and next generation sequencing (RNA-seq and TCR-seq) to human patient samples after exposure to pathogens of global importance (Malaria, tuberculosis and cytomegalovirus) and human tissue samples.
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