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Typically in any given year our scientists publish in excess of 600 research papers and reviews. Here we provide a selection of their research highlights. 'Highlight' papers are those led by Biomedicine Discovery Institute scientists and represent original research, published in the top journals in the field.

to October 2017

View featured publications by year

2017 | 2016 | 2015 | 2014

  2017
1 Aguilar, O.A., R. Berry, M.M. Rahim, J.J. Reichel, B. Popovic, M. Tanaka, Z. Fu, G.R. Balaji, T.N. Lau, M.M. Tu, C.L. Kirkham, A.B. Mahmoud, A. Mesci, A. Krmpotic, D.S. Allan, A.P. Makrigiannis, S. Jonjic, J. Rossjohn and J.R. Carlyle, A Viral Immunoevasin Controls Innate Immunity by Targeting the Prototypical Natural Killer Cell Receptor Family. Cell, 2017. 169(1): p. 58-71
2 Belousoff, M.J., Z. Eyal, M. Radjainia, T. Ahmed, R.S. Bamert, D. Matzov, A. Bashan, E. Zimmerman, S. Mishra, D. Cameron, H. Elmlund, A.Y. Peleg, S. Bhushan, T. Lithgow and A. Yonath, Structural Basis for Linezolid Binding Site Rearrangement in the Staphylococcus aureus Ribosome. MBio, 2017. 8(3): p. 1-7
3Chen, J.L., K.L. Walton, A. Hagg, T.D. Colgan, K. Johnson, H. Qian, P. Gregorevic and C.A. Harrison, Specific targeting of TGF-beta family ligands demonstrates distinct roles in the regulation of muscle mass in health and disease. Proc Natl Acad Sci U S A, 2017. 114(26): p. E5266-E5275
4Coles, J.A., E. Myburgh, J.M. Brewer and P.G. McMenamin, Where are we? The anatomy of the murine cortical meninges revisited for intravital imaging, immunology, and clearance of waste from the brain. Prog Neurobiol, 2017. 156: p. 107-148
5 Daley, S.R., C. Teh, D.Y. Hu, A. Strasser and D.H.D. Gray, Cell death and thymic tolerance. Immunol Rev, 2017. 277(1): p. 9-20
6Dodd, G.T., Z.B. Andrews, S.E. Simonds, N.J. Michael, M. DeVeer, J.C. Bruning, D. Spanswick, M.A. Cowley and T. Tiganis, A Hypothalamic Phosphatase Switch Coordinates Energy Expenditure with Feeding. Cell Metab, 2017. 26(2): p. 375-393 e7
7 Dyson, J.M., S.E. Conduit, S.J. Feeney, S. Hakim, T. DiTommaso, A.J. Fulcher, A. Sriratana, G. Ramm, K.A. Horan, R. Gurung, C. Wicking, I. Smyth and C.A. Mitchell, INPP5E regulates phosphoinositide-dependent cilia transition zone function. J Cell Biol, 2017. 216(1): p. 247-263
8 Farlie, P.G., N.M. Davidson, N.L. Baker, M. Raabus, K.N. Roeszler, C. Hirst, A. Major, M.M. Mariette, D.M. Lambert, A. Oshlack and C.A. Smith, Co-option of the cardiac transcription factor Nkx2.5 during development of the emu wing. Nat Commun, 2017. 8(1): p. 1-12
9Fleuren, E.D.G., M. Vlenterie, W.T.A. van der Graaf, M.H.S. Hillebrandt-Roeffen, J. Blackburn, X. Ma, H. Chan, M.C. Magias, A. van Erp, L. van Houdt, S.A.S. Cebeci, A. van de Ven, U.E. Flucke, E.E. Heyer, D.M. Thomas, C.J. Lord, K.D. Marini, V. Vaghjiani, T.R. Mercer, J.E. Cain, J. Wu, Y.M.H. Versleijen-Jonkers and R.J. Daly, Phosphoproteomic Profiling Reveals ALK and MET as Novel Actionable Targets across Synovial Sarcoma Subtypes. Cancer Res, 2017. 77(16): p. 4279-4292
10Garcia, J.E., Y.S. Hung, A.D. Greentree, M.G.P. Rosa, J.A. Endler and A.G. Dyer, Improved color constancy in honey bees enabled by parallel visual projections from dorsal ocelli. Proc Natl Acad Sci U S A, 2017. 114(29): p. 7713-7718
11Gopal, S., L. Veracini, D. Grall, C. Butori, S. Schaub, S. Audebert, L. Camoin, E. Budelet, A. Radwanska, S. Beghelli-de la Forest Divonne, S.M. Violette, P.H. Weinreb, S. Rekima, M. Ilie, A. Sudaka, P. Hofman and E. Van Obberghen-Schilling, Fibronectin-guided migration of carcinoma collectives. Nat Commun, 2017. 8(14150): p. 1-15
12Haqshenas, G., J. Wu, K.J. Simpson, R.J. Daly, H.J. Netter, T.F. Baumert and C. Doerig, Signalome-wide assessment of host cell response to hepatitis C virus. Nat Commun, 2017. 8: p. 15158
13Hay, I.D., M.J. Belousoff and T. Lithgow, Structural Basis of Type 2 Secretion System Engagement between the Inner and Outer Bacterial Membranes. MBio, 2017. 8(5): p. 1-6
14J.A. Powell, S.M. Pitson, J. Zuber, R.W. Johnstone, M.A. Dawson, M.A. Guthridge, A. Wei, G.A. McArthur, R.B. Pearson and R.D. Hannan, Inhibition of Pol I transcription treats murine and human AML by targeting the leukemia-initiating cell population. Blood, 2017. 129(21): p. 2882-2895
15 Hu, D.Y., R.C. Wirasinha, C.C. Goodnow and S.R. Daley, IL-2 prevents deletion of developing T-regulatory cells in the thymus. Cell Death Differ, 2017. 24(6): p. 1007-1016
16Huma, Z.E., J. Sanchez, H.D. Lim, J.L. Bridgford, C. Huang, B.J. Parker, J.G. Pazhamalil, B.T. Porebski, K.D.G. Pfleger, J.R. Lane, M. Canals and M.J. Stone, Key determinants of selective binding and activation by the monocyte chemoattractant proteins at the chemokine receptor CCR2. Sci Signal, 2017. 10(480): p. 1-14
17Hun, M., M. Barsanti, K. Wong, J. Ramshaw, J. Werkmeister and A.P. Chidgey, Native thymic extracellular matrix improves in vivo thymic organoid T cell output, and drives in vitro thymic epithelial cell differentiation. Biomaterials, 2017. 118: p. 1-15
18Juozaityte, V., D. Pladevall-Morera, A. Podolska, S. Norgaard, B. Neumann and R. Pocock, The ETS-5 transcription factor regulates activity states in Caenorhabditis elegans by controlling satiety. Proc Natl Acad Sci U S A, 2017. 114(9): p. E1651-E1658
19Kanzaki, G., V.G. Puelles, L.A. Cullen-McEwen, W.E. Hoy, Y. Okabayashi, N. Tsuboi, A. Shimizu, K.M. Denton, M.D. Hughson, T. Yokoo and J.F. Bertram, New insights on glomerular hyperfiltration: a Japanese autopsy study. JCI Insight, 2017. 2(19): p. 1-11
20Keller, A.N., S.B. Eckle, W. Xu, L. Liu, V.A. Hughes, J.Y. Mak, B.S. Meehan, T. Pediongco, R.W. Birkinshaw, Z. Chen, H. Wang, C. D'Souza, L. Kjer-Nielsen, N.A. Gherardin, D.I. Godfrey, L. Kostenko, A.J. Corbett, A.W. Purcell, D.P. Fairlie, J. McCluskey and J. Rossjohn, Drugs and drug-like molecules can modulate the function of mucosal-associated invariant T cells. Nat Immunol, 2017. 18(4): p. 402-411
21Kittila, T., C. Kittel, J. Tailhades, D. Butz, M. Schoppet, A. Buttner, R.J.A. Goode, R.B. Schittenhelm, K.H. van Pee, R.D. Sussmuth, W. Wohlleben, M.J. Cryle and E. Stegmann, Halogenation of glycopeptide antibiotics occurs at the amino acid level during non-ribosomal peptide synthesis. Chem Sci, 2017. 8(9): p. 5992-6004
22Lake, N.J., B.D. Webb, D.A. Stroud, T.R. Richman, B. Ruzzenente, A.G. Compton, H.S. Mountford, J. Pulman, C. Zangarelli, M. Rio, N. Bodaert, Z. Assouline, M.D. Sherpa, E.E. Schadt, S.M. Houten, J. Byrnes, E.M. McCormick, Z. Zolkipli-Cunningham, K. Haude, Z. Zhang, K. Retterer, R. Bai, S.E. Calvo, V.K. Mootha, J. Christodoulou, A. Rotig, A. Filipovska, I. Cristian, M.J. Falk, M.D. Metodiev and D.R. Thorburn, Biallelic Mutations in MRPS34 Lead to Instability of the Small Mitoribosomal Subunit and Leigh Syndrome. Am J Hum Genet, 2017. 101(2): p. 239-254
23Marino, E., J.L. Richards, K.H. McLeod, D. Stanley, Y.A. Yap, J. Knight, C. McKenzie, J. Kranich, A.C. Oliveira, F.J. Rossello, B. Krishnamurthy, C.M. Nefzger, L. Macia, A. Thorburn, A.G. Baxter, G. Morahan, L.H. Wong, J.M. Polo, R.J. Moore, T.J. Lockett, J.M. Clarke, D.L. Topping, L.C. Harrison and C.R. Mackay, Gut microbial metabolites limit the frequency of autoimmune T cells and protect against type 1 diabetes. Nat Immunol, 2017. 18(5): p. 552-562
24Marques, F.Z., E. Nelson, P.Y. Chu, D. Horlock, A. Fiedler, M. Ziemann, J.K. Tan, S. Kuruppu, N.W. Rajapakse, A. El-Osta, C.R. Mackay and D.M. Kaye, High-Fiber Diet and Acetate Supplementation Change the Gut Microbiota and Prevent the Development of Hypertension and Heart Failure in Hypertensive Mice. Circulation, 2017. 135(10): p. 964-977
25Nabti, I., R. Grimes, H. Sarna, P. Marangos and J. Carroll, Maternal age-dependent APC/C-mediated decrease in securin causes premature sister chromatid separation in meiosis II. Nat Commun, 2017. 8(15346): p. 1-9
26Ooi, J.D., J. Petersen, Y.H. Tan, M. Huynh, Z.J. Willett, S.H. Ramarathinam, P.J. Eggenhuizen, K.L. Loh, K.A. Watson, P.Y. Gan, M.A. Alikhan, N.L. Dudek, A. Handel, B.G. Hudson, L. Fugger, D.A. Power, S.G. Holt, P.T. Coates, J.W. Gregersen, A.W. Purcell, S.R. Holdsworth, N.L. La Gruta, H.H. Reid, J. Rossjohn and A.R. Kitching, Dominant protection from HLA-linked autoimmunity by antigen-specific regulatory T cells. Nature, 2017. 545(7653): p. 243-247
27Padman, B.S., T.N. Nguyen and M. Lazarou, Autophagosome formation and cargo sequestration in the absence of LC3/GABARAPs. Autophagy, 2017. 13(4): p. 772-774
28Piovesan, D., J. Tempany, A. Di Pietro, I. Baas, C. Yiannis, K. O'Donnell, Y. Chen, V. Peperzak, G.T. Belz, C.R. Mackay, G.K. Smyth, J.R. Groom, D.M. Tarlinton and K.L. Good-Jacobson, c-Myb Regulates the T-Bet-Dependent Differentiation Program in B Cells to Coordinate Antibody Responses. Cell Rep, 2017. 19(3): p. 461-470
29Porter, L.H., M.G. Lawrence, D. Ilic, D. Clouston, D.M. Bolton, M. Frydenberg, D.G. Murphy, C. Pezaro, G.P. Risbridger and R.A. Taylor, Systematic Review Links the Prevalence of Intraductal Carcinoma of the Prostate to Prostate Cancer Risk Categories. Eur Urol, 2017. E-pub: p. 1-4
30Pymm, P., P.T. Illing, S.H. Ramarathinam, G.M. O'Connor, V.A. Hughes, C. Hitchen, D.A. Price, B.K. Ho, D.W. McVicar, A.G. Brooks, A.W. Purcell, J. Rossjohn and J.P. Vivian, MHC-I peptides get out of the groove and enable a novel mechanism of HIV-1 escape. Nat Struct Mol Biol, 2017. 24(4): p. 387-394
31Rosenbluh, J., H. Xu, W. Harrington, S. Gill, X. Wang, F. Vazquez, D.E. Root, A. Tsherniak and W.C. Hahn, Complementary information derived from CRISPR Cas9 mediated gene deletion and suppression. Nat Commun, 2017. 8: p. 1-8
32Scally, S.W., S.C. Law, Y.T. Ting, J.V. Heemst, J. Sokolove, A.J. Deutsch, E. Bridie Clemens, A.K. Moustakas, G.K. Papadopoulos, D.V. Woude, I. Smolik, C.A. Hitchon, D.B. Robinson, E.D. Ferucci, C.N. Bernstein, X. Meng, V. Anaparti, T. Huizinga, K. Kedzierska, H.H. Reid, S. Raychaudhuri, R.E. Toes, J. Rossjohn, H. El-Gabalawy and R. Thomas, Molecular basis for increased susceptibility of Indigenous North Americans to seropositive rheumatoid arthritis. Ann Rheum Dis, 2017. 76(11): p. 1915-1923
33Shahine, A., I. Van Rhijn, T.Y. Cheng, S. Iwany, S. Gras, D.B. Moody and J. Rossjohn, A molecular basis of human T cell receptor autoreactivity toward self-phospholipids. Sci Immunol, 2017. 2(16): p. 1-12
34Singh, R.R., V. Sajeesh, L.C. Booth, Z. McArdle, C.N. May, G.A. Head, K.M. Moritz, M.P. Schlaich and K.M. Denton, Catheter-Based Renal Denervation Exacerbates Blood Pressure Fall During Hemorrhage. J Am Coll Cardiol, 2017. 69(8): p. 951-964
35Taylor, R.A., M. Fraser, J. Livingstone, S.M. Espiritu, H. Thorne, V. Huang, W. Lo, Y.J. Shiah, T.N. Yamaguchi, A. Sliwinski, S. Horsburgh, A. Meng, L.E. Heisler, N. Yu, F. Yousif, M. Papargiris, M.G. Lawrence, L. Timms, D.G. Murphy, M. Frydenberg, J.F. Hopkins, D. Bolton, D. Clouston, J.D. McPherson, T. van der Kwast, P.C. Boutros, G.P. Risbridger and R.G. Bristow, Germline BRCA2 mutations drive prostate cancers with distinct evolutionary trajectories. Nat Commun, 2017. 8(13672): p. 1-10
36To, E.E., R. Vlahos, R. Luong, M.L. Halls, P.C. Reading, P.T. King, C. Chan, G.R. Drummond, C.G. Sobey, B.R.S. Broughton, M.R. Starkey, R. van der Sluis, S.R. Lewin, S. Bozinovski, L.A.J. O'Neill, T. Quach, C.J.H. Porter, D.A. Brooks, J.J. O'Leary and S. Selemidis, Endosomal NOX2 oxidase exacerbates virus pathogenicity and is a target for antiviral therapy. Nat Commun, 2017. 8(1): p. 1-17
37Velkov, T., K.D. Roberts and J. Li, Rediscovering the octapeptins. Nat Prod Rep, 2017. 34(3): p. 295-309
38Wang, J., B. Yang, J. Revote, A. Leier, T.T. Marquez-Lago, G.I. Webb, J. Song, K.-C. Chou and T. Lithgow, SEQUENCE ANALYSIS: POSSUM: a bioinformatics toolkit for generating numerical sequence feature descriptors based on PSSM profiles. Bioinformatics, 2017. 33(17): p. 2756-2758
39Wang, X., K.J. Goodrich, A.R. Gooding, H. Naeem, S. Archer, R.D. Paucek, D.T. Youmans, T.R. Cech and C. Davidovich, Targeting of Polycomb Repressive Complex 2 to RNA by Short Repeats of Consecutive Guanines. Mol Cell, 2017. 65(6): p. 1056-1067 e5
40Wang H., Feng L., G.I. Webb, L. Kurgan, Song, J. and D. Lin, Critical evaluation of bioinformatics tools for the prediction of protein crystallization propensity. Brief Bioinform, 2017. E-pub: p. 1-15
41Waris, S., S.M. Garcia-Maurino, A. Sivakumaran, S.A. Beckham, F.E. Loughlin, M. Gorospe, I. Diaz-Moreno, M.C.J. Wilce and J.A. Wilce, TIA-1 RRM23 binding and recognition of target oligonucleotides. Nucleic Acids Res, 2017. 45(8): p. 4944-4957
42Wiede, F., J.A. Dudakov, K.H. Lu, G.T. Dodd, T. Butt, D.I. Godfrey, A. Strasser, R.L. Boyd and T. Tiganis, PTPN2 regulates T cell lineage commitment and alphabeta versus gammadelta specification. J Exp Med, 2017. 214(9): p. 2733-2758
43Zhang, Q.H., W.S. Yuen, D. Adhikari, J.A. Flegg, G. FitzHarris, M. Conti, P. Sicinski, I. Nabti, P. Marangos and J. Carroll, Cyclin A2 modulates kinetochore-microtubule attachment in meiosis II. J Cell Biol, 2017. 216(10): p. 3133-3143
  2016
1 An, Y., J. Wang, C. Li, A. Leier, T. Marquez-Lago, J. Wilksch, Y. Zhang, G.I. Webb, J. Song and T. Lithgow, Comprehensive assessment and performance improvement of effector protein predictors for bacterial secretion systems III, IV and VI. Brief Bioinform, 2016. E-pub: p. 1-14
2Antignano, F., M. Braam, M.R. Hughes, A.L. Chenery, K. Burrows, M.J. Gold, M.J. Oudhoff, D. Rattray, T.Y. Halim, A. Cait, F. Takei, F.M. Rossi, K.M. McNagny and C. Zaph, G9a regulates group 2 innate lymphoid cell development by repressing the group 3 innate lymphoid cell program. J Exp Med, 2016. 213(7): p. 1153-1162
3 Archer, S.K., N.E. Shirokikh, T.H. Beilharz and T. Preiss, Dynamics of ribosome scanning and recycling revealed by translation complex profiling. Nature, 2016. 535(7613): p. 570-574
4Atapattu, L., N. Saha, C. Chheang, M.F. Eissman, K. Xu, M.E. Vail, L. Hii, C. Llerena, Z. Liu, K. Horvay, H.E. Abud, U. Kusebauch, R.L. Moritz, B.S. Ding, Z. Cao, S. Rafii, M. Ernst, A.M. Scott, D.B. Nikolov, M. Lackmann and P.W. Janes, An activated form of ADAM10 is tumor selective and regulates cancer stem-like cells and tumor growth. J Exp Med, 2016. 213(9): p. 1741-1757
5 Bertram, J.F., S.L. Goldstein, L. Pape, F. Schaefer, R.C. Shroff and B.A. Warady, Kidney disease in children: latest advances and remaining challenges. Nat Rev Nephrol, 2016. 12(3): p. 182-191
6 Bhuiyan, M.S., F. Ellett, G.L. Murray, X. Kostoulias, G.M. Cerqueira, K.E. Schulze, M.H. Mahamad Maifiah, J. Li, D.J. Creek, G.J. Lieschke and A.Y. Peleg, Acinetobacter baumannii phenylacetic acid metabolism influences infection outcome through a direct effect on neutrophil chemotaxis. Proc Natl Acad Sci U S A, 2016. 113(34): p. 9599-9604
7 Chen, J.L., K.L. Walton, H. Qian, T.D. Colgan, A. Hagg, M.J. Watt, C.A. Harrison and P. Gregorevic, Differential Effects of IL6 and Activin A in the Development of Cancer-Associated Cachexia. Cancer Res, 2016. 76(18): p. 5372-5382
8 Dudkina, N.V., B.A. Spicer, C.F. Reboul, P.J. Conroy, N. Lukoyanova, H. Elmlund, R.H. Law, S.M. Ekkel, S.C. Kondos, R.J. Goode, G. Ramm, J.C. Whisstock, H.R. Saibil and M.A. Dunstone, Structure of the poly-C9 component of the complement membrane attack complex. Nat Commun, 2016. 7: p. 1-6
9 Edwards, B.A., C. Andara, S. Landry, S.A. Sands, S.A. Joosten, R.L. Owens, D.P. White, G.S. Hamilton and A. Wellman, Upper-Airway Collapsibility and Loop Gain Predict the Response to Oral Appliance Therapy in Patients with Obstructive Sleep Apnea. Am J Respir Crit Care Med, 2016. 194(11): p. 1413-1422
10 Fernandez-Ruiz, D., W.Y. Ng, L.E. Holz, J.Z. Ma, A. Zaid, Y.C. Wong, L.S. Lau, V. Mollard, A. Cozijnsen, N. Collins, J. Li, G.M. Davey, Y. Kato, S. Devi, R. Skandari, M. Pauley, J.H. Manton, D.I. Godfrey, A. Braun, S.S. Tay, P.S. Tan, D.G. Bowen, F. Koch-Nolte, B. Rissiek, F.R. Carbone, B.S. Crabb, M. Lahoud, I.A. Cockburn, S.N. Mueller, P. Bertolino, G.I. McFadden, I. Caminschi and W.R. Heath, Liver-Resident Memory CD8+ T Cells Form a Front-Line Defense against Malaria Liver-Stage Infection. Immunity, 2016. 45(4): p. 889-902
11 Fleuren, E.D., L. Zhang, J. Wu and R.J. Daly, The kinome 'at large' in cancer. Nat Rev Cancer, 2016. 16(2): p. 83-98
12 Gherardin, N.A., A.N. Keller, R.E. Woolley, J. Le Nours, D.S. Ritchie, P.J. Neeson, R.W. Birkinshaw, S.B.G. Eckle, J.N. Waddington, L. Liu, D.P. Fairlie, A.P. Uldrich, D.G. Pellicci, J. McCluskey, D.I. Godfrey and J. Rossjohn, Diversity of T Cells Restricted by the MHC Class I-Related Molecule MR1 Facilitates Differential Antigen Recognition. Immunity, 2016. 44(1): p. 32-45
13 Gras, S., J. Chadderton, C.M. Del Campo, C. Farenc, F. Wiede, T.M. Josephs, X.Y.X. Sng, M. Mirams, K.A. Watson, T. Tiganis, K.M. Quinn, J. Rossjohn and N.L. La Gruta, Reversed T Cell Receptor Docking on a Major Histocompatibility Class I Complex Limits Involvement in the Immune Response. Immunity, 2016. 45(4): p. 749-760
14 Gras, S., I. Van Rhijn, A. Shahine, T.Y. Cheng, M. Bhati, L.L. Tan, H. Halim, K.D. Tuttle, L. Gapin, J. Le Nours, D.B. Moody and J. Rossjohn, T cell receptor recognition of CD1b presenting a mycobacterial glycolipid. Nat Commun, 2016. 7: p. 1-12
15 He, J., X. Zhang, Y. Wei, X. Sun, Y. Chen, J. Deng, Y. Jin, Y. Gan, X. Hu, R. Jia, C. Xu, Z. Hou, Y.A. Leong, L. Zhu, J. Feng, Y. An, Y. Jia, C. Li, X. Liu, H. Ye, L. Ren, R. Li, H. Yao, Y. Li, S. Chen, X. Zhang, Y. Su, J. Guo, N. Shen, E.F. Morand, D. Yu and Z. Li, Low-dose interleukin-2 treatment selectively modulates CD4(+) T cell subsets in patients with systemic lupus erythematosus. Nat Med, 2016. 22(9): p. 991-993
16 Hossain, M.A., M. Kocan, S.T. Yao, S.G.N. Royce, V.B., C. Siwek, P. N.A., I.P. Harrison, K.J. Rosengren, S. Selemidis, R.F. Summers, J.D. Wade, R.A. Bathgate and C.S. Samuel, EDGE ARTICLE: A single-chain derivative of the relaxin hormone is a functionally selective agonist of the G protein-coupled receptor, RXFP1 Chem Sci, 2016. 7: p. 3805-3819
17 Jarde, T., B. Lloyd-Lewis, M. Thomas, H. Kendrick, L. Melchor, L. Bougaret, P.D. Watson, K. Ewan, M.J. Smalley and T.C. Dale, Wnt and Neuregulin1/ErbB signalling extends 3D culture of hormone responsive mammary organoids. Nat Commun, 2016. 7: p. 1-14
18 Jore, M.M., S. Johnson, D. Sheppard, N.M. Barber, Y.I. Li, M.A. Nunn, H. Elmlund and S.M. Lea, Structural basis for therapeutic inhibition of complement C5. Nat Struct Mol Biol, 2016. 23(5): p. 378-386
19 Kim, J.H., Y. Hu, T. Yongqing, J. Kim, V.A. Hughes, J. Le Nours, E.A. Marquez, A.W. Purcell, Q. Wan, M. Sugita, J. Rossjohn and F. Winau, CD1a on Langerhans cells controls inflammatory skin disease. Nat Immunol, 2016. 17(10): p. 1159-1166
20 Kittila, T., A. Mollo, L.K. Charkoudian and M.J. Cryle, New Structural Data Reveal the Motion of Carrier Proteins in Nonribosomal Peptide Synthesis. Angew Chem Int Ed Engl, 2016. 55(34): p. 9834-9840
21 Larcombe, S., M.L. Hutton and D. Lyras, Involvement of Bacteria Other Than Clostridium difficile in Antibiotic-Associated Diarrhoea. Trends Microbiol, 2016. 24(6): p. 463-476
22 Le Nours, J., T. Praveena, D.G. Pellicci, N.A. Gherardin, F.J. Ross, R.T. Lim, G.S. Besra, S. Keshipeddy, S.K. Richardson, A.R. Howell, S. Gras, D.I. Godfrey, J. Rossjohn and A.P. Uldrich, Atypical natural killer T-cell receptor recognition of CD1d-lipid antigens. Nat Commun, 2016. 7: p. 1-14
23 Leong, Y.A., Y. Chen, H.S. Ong, D. Wu, K. Man, C. Deleage, M. Minnich, B.J. Meckiff, Y. Wei, Z. Hou, D. Zotos, K.A. Fenix, A. Atnerkar, S. Preston, J.G. Chipman, G.J. Beilman, C.C. Allison, L. Sun, P. Wang, J. Xu, J.G. Toe, H.K. Lu, Y. Tao, U. Palendira, A.L. Dent, A.L. Landay, M. Pellegrini, I. Comerford, S.R. McColl, T.W. Schacker, H.M. Long, J.D. Estes, M. Busslinger, G.T. Belz, S.R. Lewin, A. Kallies and D. Yu, CXCR5(+) follicular cytotoxic T cells control viral infection in B cell follicles. Nat Immunol, 2016. 17(10): p. 1187-1196
24 McWilliam, H.E., S.B. Eckle, A. Theodossis, L. Liu, Z. Chen, J.M. Wubben, D.P. Fairlie, R.A. Strugnell, J.D. Mintern, J. McCluskey, J. Rossjohn and J.A. Villadangos, The intracellular pathway for the presentation of vitamin B-related antigens by the antigen-presenting molecule MR1. Nat Immunol, 2016. 17(5): p. 531-537
25 Nguyen, T.N., B.S. Padman, J. Usher, V. Oorschot, G. Ramm and M. Lazarou, Atg8 family LC3/GABARAP proteins are crucial for autophagosome-lysosome fusion but not autophagosome formation during PINK1/Parkin mitophagy and starvation. J Cell Biol, 2016. 215(6): p. 857-874
26 Nichols, A.L., E. Meelkop, C. Linton, R. Giordano-Santini, R.K. Sullivan, A. Donato, C. Nolan, D.H. Hall, D. Xue, B. Neumann and M.A. Hilliard, The Apoptotic Engulfment Machinery Regulates Axonal Degeneration in C. elegans Neurons. Cell Rep, 2016. 14(7): p. 1673-1683
27 Oudhoff, M.J., M.J. Braam, S.A. Freeman, D. Wong, D.G. Rattray, J. Wang, F. Antignano, K. Snyder, I. Refaeli, M.R. Hughes, K.M. McNagny, M.R. Gold, C.H. Arrowsmith, T. Sato, F.M. Rossi, J.H. Tatlock, D.R. Owen, P.J. Brown and C. Zaph, SETD7 Controls Intestinal Regeneration and Tumorigenesis by Regulating Wnt/beta-Catenin and Hippo/YAP Signaling. Dev Cell, 2016. 37(1): p. 47-57
28 Peschke, M., K. Haslinger, C. Brieke, J. Reinstein and M.J. Cryle, Regulation of the P450 Oxygenation Cascade Involved in Glycopeptide Antibiotic Biosynthesis. J Am Chem Soc, 2016. 138(21): p. 6746-6753
29 Puelles, V.G., J.W. van der Wolde, K.E. Schulze, K.M. Short, M.N. Wong, J.G. Bensley, L.A. Cullen-McEwen, G. Caruana, S.N. Hokke, J. Li, S.D. Firth, I.S. Harper, D.J. Nikolic-Paterson and J.F. Bertram, Validation of a Three-Dimensional Method for Counting and Sizing Podocytes in Whole Glomeruli. J Am Soc Nephrol, 2016. 27(10): p. 3093-3104
30 Rackham, O.J., J. Firas, H. Fang, M.E. Oates, M.L. Holmes, A.S. Knaupp, F. Consortium, H. Suzuki, C.M. Nefzger, C.O. Daub, J.W. Shin, E. Petretto, A.R. Forrest, Y. Hayashizaki, J.M. Polo and J. Gough, A predictive computational framework for direct reprogramming between human cell types. Nat Genet, 2016. 48(3): p. 331-335
31 Rebello, R.J., E. Kusnadi, D.P. Cameron, H.B. Pearson, A. Lesmana, J.R. Devlin, D. Drygin, A.K. Clark, L. Porter, J. Pedersen, S. Sandhu, G.P. Risbridger, R.B. Pearson, R.D. Hannan and L. Furic, The Dual Inhibition of RNA Pol I Transcription and PIM Kinase as a New Therapeutic Approach to Treat Advanced Prostate Cancer. Clin Cancer Res, 2016. 22(22): p. 5539-5552
32 Ribas, V., B.G. Drew, Z. Zhou, J. Phun, N.Y. Kalajian, T. Soleymani, P. Daraei, K. Widjaja, J. Wanagat, T.Q. de Aguiar Vallim, A.H. Fluitt, S. Bensinger, T. Le, C. Radu, J.P. Whitelegge, S.W. Beaven, P. Tontonoz, A.J. Lusis, B.W. Parks, L. Vergnes, K. Reue, H. Singh, J.C. Bopassa, L. Toro, E. Stefani, M.J. Watt, S. Schenk, T. Akerstrom, M. Kelly, B.K. Pedersen, S.C. Hewitt, K.S. Korach and A.L. Hevener, Skeletal muscle action of estrogen receptor alpha is critical for the maintenance of mitochondrial function and metabolic homeostasis in females. Sci Transl Med, 2016. 8(334): p. 1-47
33 Sarker, S., M.C. Terron, Y. Khandokar, D. Aragao, J.M. Hardy, M. Radjainia, M. Jimenez-Zaragoza, P.J. de Pablo, F. Coulibaly, D. Luque, S.R. Raidal and J.K. Forwood, Structural insights into the assembly and regulation of distinct viral capsid complexes. Nat Commun, 2016. 7: p. 1-7
34 Saunders, P.M., P. Pymm, G. Pietra, V.A. Hughes, C. Hitchen, G.M. O'Connor, F. Loiacono, J. Widjaja, D.A. Price, M. Falco, M.C. Mingari, L. Moretta, D.W. McVicar, J. Rossjohn, A.G. Brooks and J.P. Vivian, Killer cell immunoglobulin-like receptor 3DL1 polymorphism defines distinct hierarchies of HLA class I recognition. J Exp Med, 2016. 213(5): p. 791-807
35 Short, K.M. and I.M. Smyth, The contribution of branching morphogenesis to kidney development and disease. Nat Rev Nephrol, 2016. 12(12): p. 754-767
36 Speir, M., K.E. Lawlor, S.P. Glaser, G. Abraham, S. Chow, A. Vogrin, K.E. Schulze, R. Schuelein, L.A. O'Reilly, K. Mason, E.L. Hartland, T. Lithgow, A. Strasser, G. Lessene, D.C. Huang, J.E. Vince and T. Naderer, Eliminating Legionella by inhibiting BCL-XL to induce macrophage apoptosis. Nat Microbiol, 2016. 1: p. 1-9
37 Stroud, D.A., E.E. Surgenor, L.E. Formosa, B. Reljic, A.E. Frazier, M.G. Dibley, L.D. Osellame, T. Stait, T.H. Beilharz, D.R. Thorburn, A. Salim and M.T. Ryan, Accessory subunits are integral for assembly and function of human mitochondrial complex I. Nature, 2016. 538(7623): p. 123-126
38 Stubenrauch, C., M.J. Belousoff, I.D. Hay, H.H. Shen, J. Lillington, K.L. Tuck, K.M. Peters, M.D. Phan, A.W. Lo, M.A. Schembri, R.A. Strugnell, G. Waksman and T. Lithgow, Effective assembly of fimbriae in Escherichia coli depends on the translocation assembly module nanomachine. Nat Microbiol, 2016. 1(7): p. 1-8
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40Tan, J., C. McKenzie, P.J. Vuillermin, G. Goverse, C.G. Vinuesa, R.E. Mebius, L. Macia and C.R. Mackay, Dietary Fiber and Bacterial SCFA Enhance Oral Tolerance and Protect against Food Allergy through Diverse Cellular Pathways. Cell Rep, 2016. 15(12): p. 2809-2824
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  2015
1 Atkinson, S.C., J.S. Armistead, D.K. Mathias, M.M. Sandeu, D. Tao, N. Borhani-Dizaji, B.B. Tarimo, I. Morlais, R.R. Dinglasan and N.A. Borg, The Anopheles-midgut APN1 structure reveals a new malaria transmission-blocking vaccine epitope. Nat Struct     Mol     Biol,     2015. E-pub:     p.     1-9     Category:     Biochemistry     &     Molecular     Biology Impact Factor: 13.309 Ranking:     7/289.
2 Beringer, D.X., F.S. Kleijwegt, F. Wiede, A.R. van der Slik, K.L. Loh, J. Petersen, N.L. Dudek, G. Duinkerken, S. Laban, A. Joosten, J.P. Vivian, Z. Chen, A.P. Uldrich, D.I. Godfrey, J. McCluskey, D.A. Price,     K.J.     Radford,     A.W.     Purcell,     T.     Nikolic, H.H. Reid, T. Tiganis,     B.O.     Roep     and J. Rossjohn, T cell receptor reversed polarity recognition of a self-antigen major histocompatibility complex. Nat Immunol, 2015. E-pub: p. 1-11 Category: Immunology Impact Factor: 20.004 Ranking: 4/148.
3 Birkinshaw, R.W., D.G. Pellicci, T.Y. Cheng, A.N. Keller, M. Sandoval-Romero, S. Gras, A. de Jong, A.P. Uldrich, D.B. Moody, D.I. Godfrey and J. Rossjohn, {alphabeta} T cell antigen receptor recognition of CD1a presenting self lipid ligands. Nat Immunol, 2015. 16(3): p. 258-266 Category: Immunology Impact Factor: 20.004 Ranking: 4/148.
4Chang, C.C., B.T. Tey, J. Song, and R.N. Ramanan. Towards more accurate prediction of protein folding rates: a review of the existing Web-based bioinformatics approaches. Briefings in Bioinformatics. 2015, 16(2): 314-324.  Category: Biochemical Research Methods Impact Factor: 9.617 Ranking:     3/79.
5 Chang, F.T., F.L. Chan, R.M. JD, M. Udugama, L. Mayne, P. Collas, J.R. Mann and L.H. Wong, CHK1-driven histone H3.3 serine 31 phosphorylation is important for chromatin maintenance and cell survival in human ALT cancer cells. Nucleic Acids Res, 2015. 43(5): p. 2603-2614 Category: Biochemistry & Molecular Biology Impact Factor: 9.112 Ranking: 20/289.
6 Chen, Z., Y. Zhou, Z. Zhang and J. Song, Towards more accurate prediction of ubiquitination sites: a comprehensive review of current methods, tools and features. Brief Bioinform, 2015. 16(4): p. 640-657 Category: Biochemical Research Methods Impact Factor: 9.617 Ranking:     3/79.
7

Chiu, E., M. Hijnen, R.D. Bunker, M. Boudes, C. Rajendran, K. Aizel, V. Olieric, C. Schulze-Briese, W. Mitsuhashi, V. Young, V.K. Ward, M. Bergoin, P. Metcalf and F. Coulibaly, Structural basis for the enhancement of virulence by viral spindles and their in vivo crystallization. Proc Natl Acad Sci U S A, 2015. 112(13): p. 3973-3978 Category: Multidisciplinary Sciences Impact Factor: 9.674 Ranking: 4/56.

8 Davies, E.M., A.M. Kong, A. Tan, R. Gurung, A. Sriratana, P.E. Bukczynska, L.M. Ooms, C.A. McLean, T. Tiganis and C.A. Mitchell, Differential SKIP expression in PTEN-deficient glioblastoma regulates cellular proliferation and migration. Oncogene, 2014. 34(28): p. 3711-3727 Category: Oncology Impact Factor: 8.459 Ranking: 13/211.
9 Dodd, G.T., S. Decherf, K. Loh, S.E. Simonds, F. Wiede, E. Balland, T.L. Merry, H. Munzberg, Z.Y. Zhang, B.B. Kahn, B.G. Neel, K.K. Bence, Z.B. Andrews, M.A. Cowley and T. Tiganis, Leptin and insulin act on POMC neurons to promote the browning of white fat. Cell, 2015. 160(1-2): p. 88-104 Category: Biochemistry & Molecular Biology Impact Factor: 32.242 Ranking: 1/289.
10

Doerig, C., J.C. Rayner, A. Scherf and A.B. Tobin, Post-translational protein modifications in malaria parasites. Nat Rev Microbiol, 2015. 13(3): p. 160-172 Category: Microbiology Impact Factor: 23.574 Ranking: 1/119.

11 Hobbs, R.M., H.M. La, J.A. Makela, T. Kobayashi, T. Noda and P.P. Pandolfi, Distinct germline progenitor subsets defined through Tsc2-mTORC1 signaling. EMBO Rep, 2015. 16(4): p. 467-480 Category: Biochemistry     &     Molecular     Biology Impact Factor: 9.055 Ranking:     22/289.
12 Horvay, K., T. Jarde, F. Casagranda, V.M. Perreau, K. Haigh, C.M. Nefzger, R. Akhtar, T. Gridley, G. Berx, J.J. Haigh, N. Barker, J.M. Polo, G.R. Hime and H.E. Abud, Snai1 regulates cell lineage allocation and stem cell maintenance in the mouse intestinal epithelium. EMBO J, 2015. 34(10): p. 1319-1335 Category: Biochemistry & Molecular Biology Impact Factor: 10.434 Ranking: 11/289.
13 Lankadeva, Y.R., R.R. Singh, K.M. Moritz, H.C. Parkington, K.M. Denton and M. Tare, Renal Dysfunction is Associated with a Reduced Contribution of Nitric Oxide and Enhanced Vasoconstriction Following a Congenital Renal Mass Reduction in Sheep. Circulation, 2015. 131(3): p. 280-288 Category: Peripheral Vascular Disease Impact Factor: 14.430 Ranking: 1/60.
14 Lazarou, M., D.A. Sliter, L.A. Kane, S.A. Sarraf, C. Wang, J.L. Burman, D.P. Sideris, A.I. Fogel and R.J. Youle, The ubiquitin kinase PINK1 recruits autophagy receptors to induce mitophagy. Nature, 2015. 524(7565): p. 309-314 Category: Multidisciplinary     Sciences Impact Factor: 41.456 Ranking:     1/57.
15 Li, C., C. Ching Han Chang, J. Nagel, B.T. Porebski, M. Hayashida, T. Akutsu, J. Song and A.M. Buckle, Critical evaluation of in silico methods for prediction of coiled-coil domains in proteins. Brief Bioinform, 2015. E-pub: p. 1-13 Category: Biochemical Research Methods Impact Factor: 9.617 Ranking:     3/79.
16 Lukoyanova, N., S.C. Kondos, I. Farabella, R.H. Law, C.F. Reboul, T.T. Caradoc-Davies, B.A. Spicer, O. Kleifeld, D.A. Traore, S.M. Ekkel, I. Voskoboinik, J.A. Trapani, T. Hatfaludi,     K.     Oliver,     E.M.     Hotze,     R.K.     Tweten, J.C. Whisstock,     M.     Topf,     H.R.     Saibil     and M.A. Dunstone, Conformational Changes during Pore Formation by the Perforin-Related Protein Pleurotolysin. PLoS Biol, 2015. 13(2): p. e1002049.1-15 Category:     Biochemistry     &     Molecular     Biology Impact Factor: 9.343 Ranking:     17/289.
17 Macia, L., J. Tan, A.T. Vieira, K. Leach, D. Stanley, S. Luong, M. Maruya, C. Ian McKenzie, A. Hijikata, C. Wong, L. Binge, A.N. Thorburn, N. Chevalier, C. Ang, E. Marino, R. Robert,     S.     Offermanns,     M.M.     Teixeira, R.J. Moore,     R.A.     Flavell,     S.     Fagarasan     and C.R. Mackay, Metabolite-sensing receptors GPR43 and GPR109A facilitate dietary fibre-induced gut homeostasis through regulation of the inflammasome. Nat Commun, 2015. 6(Article:     6734)Category:     Multidisciplinary     Sciences Impact Factor: 11.470 Ranking:     3/56.
18 Mansouri, F.A., M.J. Buckley, M. Mahboubi and K. Tanaka, Behavioral consequences of selective damage to frontal pole and posterior cingulate cortices. Proc Natl Acad Sci U S A, 2015. 112(29): p. E3940-3949 Category: Multidisciplinary Sciences Impact Factor: 9.674 Ranking:     4/56.
19 Ooms, L.M., L.C. Binge, E.M. Davies, P. Rahman, J.R. Conway, R. Gurung, D.T. Ferguson, A. Papa, C.G. Fedele, J.L. Vieusseux, R.C. Chai,     F.     Koentgen, J.T. Price, T. Tiganis,     P.     Timpson,     C.A.     McLean     and C.A. Mitchell, The Inositol Polyphosphate 5-Phosphatase PIPP Regulates AKT1-Dependent Breast Cancer Growth and Metastasis. Cancer Cell, 2015. 28(2):     p.     155-169     Category:     Oncology Impact Factor: 23.523 Ranking:     4/184.
20 Puelles, V.G., R.N. Douglas-Denton, L.A. Cullen-McEwen, J. Li, M.D. Hughson, W.E. Hoy, P.G. Kerr and J.F. Bertram, Podocyte Number in Children and Adults: Associations with Glomerular Size and Numbers of Other Glomerular Resident Cells. J Am Soc Nephrol, 2015. E-pub: p. 1-XX Category: Urology & Nephrology Impact Factor: 9.343 Ranking: 3/76.
21 Qu, X., M. Jiang, Y.B. Sun, X. Jiang, P. Fu, Y. Ren, D. Wang, L. Dai, G. Caruana, J.F. Bertram, D.J. Nikolic-Paterson and J. Li, The Smad3/Smad4/CDK9 complex promotes renal fibrosis in mice with unilateral ureteral obstruction. Kidney Int, 2015. E-pub: p. 1-13 Category: Urology & Nephrology Impact Factor: 8.563 Ranking: 4/76.
22

Risbridger, G.P., R.A. Taylor, D. Clouston, A. Sliwinski, H. Thorne, S. Hunter, J. Li, G. Mitchell, D. Murphy, M. Frydenberg, D. Pook, J. Pedersen, R. Toivanen, H. Wang, M. Papargiris, M.G. Lawrence and D.M. Bolton, Patient-derived Xenografts Reveal that Intraductal Carcinoma of the Prostate Is a Prominent Pathology in BRCA2 Mutation Carriers with Prostate Cancer and Correlates with Poor Prognosis. Eur Urol, 2015. 67(3): p. 496-503 Category: Urology     &     Nephrology Impact Factor: 13.938 Ranking:     1/76.

23 Shiota, T., K. Imai, J. Qiu, V.L. Hewitt, K. Tan, H.H. Shen, N. Sakiyama, Y. Fukasawa, S. Hayat, M. Kamiya, A. Elofsson, K. Tomii, P. Horton, N. Wiedemann, N. Pfanner, T. Lithgow and T. Endo, RESEARCH REPORT: Molecular architecture of the active mitochondrial protein gate. Science, 2015. 349(6255): p. 1544-1548 Category: Multidisciplinary Sciences Impact Factor: 33.611 Ranking: 2/56.
24 Stone, M.J. and R.J. Payne, Homogeneous Sulfopeptides and Sulfoproteins: Synthetic Approaches and Applications To Characterize the Effects of Tyrosine Sulfation on Biochemical Function. Acc Chem Res, 2015. 48(8): p. 2251-2261 Category: Chemistry,     Multidisciplinary Impact Factor: 22.323 Ranking:     4/157.
  2014
1 Bird, C.H., M.E. Christensen, M.S. Mangan, M.D. Prakash, K.A. Sedelies, M.J. Smyth, I. Harper, N.J. Waterhouse and P.I. Bird, The granzyme B-Serpinb9 axis controls the fate of lymphocytes after lysosomal stress. Cell Death Differ, 2014. 21: p. 876-887 Category: Biochemistry & Molecular Biology Impact Factor: 8.385 Ranking: 25/291.
2

Borg, M.L., M. Lemus, A. Reichenbach, A. Selathurai, B.J. Oldfield, Z.B. Andrews and M.J. Watt, Hypothalamic neurogenesis is not required for the improved insulin sensitivity following exercise training. Diabetes, 2014. 63(11): p. 3647-3658 Category: Endocrinology & Metabolism. Impact Factor: 8.474 Ranking: 6/123.

3 Boyd, A.W., P.F. Bartlett and M. Lackmann, Therapeutic targeting of EPH receptors and their ligands. Nat Rev Drug Discov, 2014. 13(1): p. 39-62 Category: Biotechnology & Applied Microbiology Impact Factor: 37.231 Ranking: 2/165.
4 Chow, B.S., M. Kocan, S. Bosnyak, M. Sarwar, B. Wigg, E.S. Jones, R.E. Widdop, R.J. Summers, R.A. Bathgate, T.D. Hewitson and C.S. Samuel, Relaxin requires the angiotensin II type 2 receptor to abrogate renal interstitial fibrosis. Kidney Int, 2014. 86(1): p. 75-85 Category: Urology & Nephrology Impact Factor: 8.520 Ranking: 3/75.
5 Corbett, A.J., S.B. Eckle, R.W. Birkinshaw, L. Liu, O. Patel, J. Mahony, Z. Chen, R. Reantragoon, B. Meehan, H. Cao, N.A. Williamson, R.A. Strugnell, D. Van Sinderen, J.Y. Mak, D.P. Fairlie, L. Kjer-Nielsen, J. Rossjohn and J. McCluskey, T-cell activation by transitory neo-antigens derived from distinct microbial pathways. Nature, 2014. 509: p. 361-365 Category: Multidisciplinary Sciences Impact Factor: 42.351 Ranking: 1/55.
6 DiTommaso, T., D.L. Cottle, H.B. Pearson, H. Schluter, P. Kaur, P.O. Humbert and I.M. Smyth, Keratin 76 is required for tight junction function and maintenance of the skin barrier. PLoS Genet, 2014. 10(10):     p.     e1004706.1-13     Category:     Genetics     &     Heredity Impact Factor: 8.167 Ranking:     14/165.
7 DiTommaso, T., L.K. Jones, D.L. Cottle, W.M.G. Program, A.K. Gerdin, V.E. Vancollie, F.M. Watt, R. Ramirez-Solis, A. Bradley, K.P. Steel, J.P. Sundberg, J.K. White and I.M. Smyth, Identification of genes important for cutaneous function revealed by a large scale reverse genetic screen in the mouse. PLoS Genet, 2014. 10(10): p. e1004705.1-12 Category: Genetics & Heredity Impact Factor: 8.167 Ranking: 14/165.
8

Eckle, S.B., R.W. Birkinshaw, L. Kostenko, A.J. Corbett, H.E. McWilliam, R. Reantragoon, Z. Chen, N.A. Gherardin, T. Beddoe, L. Liu, O. Patel, B. Meehan, D.P. Fairlie, J.A. Villadangos, D.I. Godfrey, L. Kjer-Nielsen, J. McCluskey and J. Rossjohn, A molecular basis underpinning the T cell receptor heterogeneity of mucosal-associated invariant T cells. J Exp Med, 2014. 211(8): p. 1585-1600 Category: Immunology impact Factor: 13.912 Ranking: 5/144.

9

Ellem, S.J., E.M. De-Juan-Pardo and G.P. Risbridger, In vitro modeling of the prostate cancer microenvironment. Adv Drug Deliv Rev, 2014. 79-80: p. 214-221 Category: Pharmacology & Pharmacy Impact Factor: 12.707 Ranking:     4/254.

10

Gurzov, E.N., M. Tran, M.A. Fernandez-Rojo, T.L. Merry, X. Zhang, Y. Xu, A. Fukushima, M.J. Waters, M.J. Watt, S. Andrikopoulos, B.G. Neel and T. Tiganis, Hepatic Oxidative Stress Promotes Insulin-STAT-5 Signaling and Obesity by Inactivating Protein Tyrosine Phosphatase N2. Cell Metab, 2014. 20(1): p. 85-102 Category: Cell Biology Impact Factor: 16.747 Ranking: 8/185.

11 Henstridge, M.A., T.K. Johnson, C.G. Warr and J.C. Whisstock, Trunk cleavage is essential for Drosophila terminal patterning and can occur independently of Torso-like. Nat Commun, 2014. 5: p. 3419.1-7 Category: Multidisciplinary     Sciences Impact Factor: 10.742 Ranking:     3/55.
12 Kass, I., D.E. Hoke, M.G. Costa, C.F. Reboul, B.T. Porebski, N.P. Cowieson, H. Leh, E. Pennacchietti, J. McCoey, O. Kleifeld, C. Borri Voltattorni, D. Langley, B. Roome, I.R. Mackay, D. Christ,     D.     Perahia,     M.     Buckle,     A.     Paiardini,     D.     De     Biase     and A.M. Buckle, Cofactor-dependent conformational heterogeneity of GAD65 and its role in autoimmunity and neurotransmitter homeostasis. Proc Natl Acad Sci U S A, 2014. 111(25): p. E2524-2529     Category:     Multidisciplinary     Sciences Impact Factor: 9.809 Ranking:     4/55.
13 Leyton, D.L., M.D. Johnson, R. Thapa, G.H. Huysmans, R.A. Dunstan, N. Celik, H.H. Shen, D. Loo, M.J. Belousoff, A.W. Purcell, I.R. Henderson, T. Beddoe, J. Rossjohn,     L.L.     Martin,     R.A.     Strugnell     and T. Lithgow, A mortise-tenon joint in the transmembrane domain modulates autotransporter assembly into bacterial outer membranes. Nat Commun, 2014. 5: p. 4239.1-11 Category: Multidisciplinary Sciences Impact Factor: 10.742 Ranking:     3/55.
14 Lieu, K.G., E.H. Shim, J. Wang, R.K. Lokareddy, T. Tao, G. Cingolani, G.P. Zambetti and D.A. Jans, The p53-induced factor Ei24 inhibits nuclear import through an importin beta-binding-like domain. J Cell Biol, 2014. 205(3):     p.     301-312     Category:     Cell     Biology Impact Factor: 9.688 Ranking:     21/185.
15 Nabti, I., P. Marangos, J. Bormann, N.R. Kudo and J. Carroll, Dual-mode regulation of the APC/C by CDK1 and MAPK controls meiosis I progression and fidelity. J Cell Biol, 2014. 204(6): p. 891-900 Category: Cell Biology Impact Factor: 9.688 Ranking: 21/185.
16 Parkington, H.C., J. Stevenson, M.A. Tonta, J. Paul, T. Butler, K. Maiti, E.C. Chan, P.M. Sheehan, S.P. Brennecke, H.A. Coleman and R. Smith, Diminished hERG K+ channel activity facilitates strong human labour contractions but is dysregulated in obese women. Nat Commun, 2014. 5(Article #4108): p. 1-8 Category: Multidisciplinary Sciences Impact Factor: 10.742 Ranking: 3/55.
17 Pellicci, D.G., A.P. Uldrich, J. Le Nours, F. Ross, E. Chabrol, S.B. Eckle, R. de Boer, R.T. Lim, K. McPherson, G. Besra, A.R. Howell, L. Moretta, J. McCluskey, M.H. Heemskerk, S. Gras, J. Rossjohn and D.I. Godfrey, The molecular bases of delta/alphabeta T cell-mediated antigen recognition. J Exp Med, 2014. 211(13): p. 2599-2615 Category: Immunology Impact Factor: 13.912 Ranking: 5/144.
18 Petersen, J., V. Montserrat, J.R. Mujico, K.L. Loh, D.X. Beringer, M. van Lummel, A. Thompson, M.L. Mearin, J. Schweizer, Y. Kooy-Winkelaar, J. van Bergen, J.W. Drijfhout, W.T. Kan, N.L. La Gruta, R.P. Anderson, H.H. Reid, F. Koning and J. Rossjohn, T-cell receptor recognition of HLA-DQ2-gliadin complexes associated with celiac disease. Nat Struct Mol Biol, 2014. 21(5): p. 480-490 Category: Biochemistry & Molecular Biology Impact Factor: 11.633 Ranking: 14/291.
19 Prakash, M.D., M.A. Munoz, R. Jain, P.L. Tong, A. Koskinen, M. Regner, O. Kleifeld, B. Ho, M. Olson, S.J. Turner, P. Mrass, W. Weninger and P.I. Bird, Granzyme B promotes cytotoxic lymphocyte transmigration via basement membrane remodeling. Immunity, 2014. 41(6): p. 960-972 Category: Immunology Impact Factor: 19.748 Ranking: 4/144.
20 Shen, H.H., D.L. Leyton, T. Shiota, M.J. Belousoff, N. Noinaj, J. Lu, S.A. Holt, K. Tan, J. Selkrig, C.T. Webb, S.K. Buchanan, L.L. Martin and T. Lithgow, Reconstitution of a nanomachine driving the assembly of proteins into bacterial outer membranes. Nat Commun, 2014. 5(5078): p. 1-10 Category: Multidisciplinary Sciences Impact Factor: 10.742 Ranking: 3/55.
21 Short, K.M., A.N. Combes, J. Lefevre, A.L. Ju, K.M. Georgas, T. Lamberton, O. Cairncross, B.A. Rumballe, A.P. McMahon, N.A. Hamilton, I.M. Smyth and M.H. Little, Global quantification of tissue dynamics in the developing mouse kidney. Dev Cell, 2014. 29(2):     p.     188-202     Category:     Cell     Biology Impact Factor: 10.366 Ranking:     17/185.
22 Simonds, S.E., J.T. Pryor, E. Ravussin, F.L. Greenway, R. Dileone, A.M. Allen, J. Bassi, J.K. Elmquist, J.M. Keogh, E. Henning, M.G. Myers, Jr., J. Licinio, R.D. Brown, P.J. Enriori, S. O'Rahilly, S.M. Sternson, K.L. Grove, D.C. Spanswick,     I.S.     Farooqi     and M.A. Cowley, Leptin mediates the increase in blood pressure associated with obesity. Cell, 2014. 159(6): p. 1404-1416 Category: Biochemistry & Molecular Biology Impact Factor: 33.116 Ranking: 1/291.
23 Teoh, S.S., J. Vieusseux, M. Prakash, S. Berkowicz, J. Luu, C.H. Bird, R.H. Law, C. Rosado, J.T. Price, J.C. Whisstock and P.I. Bird, Maspin is not required for embryonic development or tumour suppression. Nat Commun, 2014. 5: p. 3164.1-9 Category: Multidisciplinary Sciences Impact Factor: 10.742 Ranking: 3/55.
24 Vail, M.E., C. Murone, A. Tan, L. Hii, D. Abebe, P.W. Janes, F.T. Lee, M. Baer, V. Palath, C. Bebbington, G. Yarranton, C. Llerena, S. Garic, D. Abramson, G. Cartwright, A.M. Scott and M. Lackmann, Targeting EphA3 Inhibits Cancer Growth by Disrupting the Tumor Stromal Microenvironment. Cancer Res, 2014. 74(16): p. 4470-4481 Category: Oncology Impact Factor: 9.284 Ranking: 10/202.
25 Wiede, F., N.L. La Gruta and T. Tiganis, PTPN2 attenuates T-cell lymphopenia-induced proliferation. Nat Commun, 2014. 5: p. 3073.1-15 Category: Multidisciplinary Sciences Impact Factor: 10.742 Ranking: 3/55.