Controlling cell behaviour – how a worm model provides a key

3D reconstruction of the cross-sectional view of Caenorhabditis elegans embryo showing EGL-20/WNT distribution (red, blue, green, purple).
3D reconstruction of the cross-sectional view of Caenorhabditis elegans embryo showing EGL-20/WNT distribution (red, blue, green, purple).

Monash researchers have discovered a mechanism regulating WNT - a crucial protein that controls cell behaviour. The international team, led by Monash BDI's Associate Professor Roger Pocock, have shown that an existing drug can be used to regulate the behaviour of cells by controlling WNT secretion. The study, published this week in Cell Reports, reveals the previously unknown relationship between two proteins, PDI-1 and WNT, and opens the path to target the PDI-1 protein as a way to potentially control cancer progression. It was featured in Science's 'In other journals' column and appeared in Mirage News.

Read the full press release here.