Study reveals factors behind embryonic stem cell state
An international collaboration led by Monash BDI's Dr Partha Das has found that two new epigenetic regulators, TAF5L and TAF6L, maintain self-renewal of embryonic stem cells. Featured on Medical Express, Brightsurf and Science Daily, the scientists also found that these proteins activate c-Myc (a well-known cancer gene), and its regulatory network. This is the first time scientists have been able to show what these regulators do and how they control gene expression. The findings, published recently in Molecular Cell, would potentially make TAF5L and TAF6L very significant not only in the regenerative biology field but also in cancer research.