Publication highlights

Typically in any given year our scientists publish in excess of 600 research papers and reviews. Here we provide a selection of their research highlights. 'Highlight' papers are those led by Biomedicine Discovery Institute scientists and represent original research, published in the top journals in the field.

As of April 2019.

View featured publications by year

2019 | 2018 | 2017 | 2016 | 2015 | 2014

1Balland, E., W. Chen, G.T. Dodd, G. Conductier, R. Coppari, T. Tiganis, and M.A. Cowley, Leptin Signaling in the Arcuate Nucleus Reduces Insulin's Capacity to Suppress Hepatic Glucose Production in Obese Mice. Cell Rep, 2019. 26(2): p. 346-355.e3.
2Croft, N.P., S.A. Smith, J. Pickering, J. Sidney, B. Peters, P. Faridi, M.J. Witney, P. Sebastian, I.E.A. Flesch, S.L. Heading, A. Sette, N.L. La Gruta, A.W. Purcell, and D.C. Tscharke, Most viral peptides displayed by class I MHC on infected cells are immunogenic. Proc Natl Acad Sci U S A, 2019. 116(8): p. 3112-3117.
3Cullen, J.G., H.A. McQuilten, K.M. Quinn, M. Olshansky, B.E. Russ, A. Morey, S. Wei, J.E. Prier, N.L. La Gruta, P.C. Doherty, and S.J. Turner, CD4(+) T help promotes influenza virus-specific CD8(+) T cell memory by limiting metabolic dysfunction. Proc Natl Acad Sci U S A, 2019.
4DeBono, A., D.R. Thomas, L. Lundberg, C. Pinkham, Y. Cao, J.D. Graham, C.L. Clarke, K.M. Wagstaff, S. Shechter, K. Kehn-Hall, and D.A. Jans, Novel RU486 (mifepristone) analogues with increased activity against Venezuelan Equine Encephalitis Virus but reduced progesterone receptor antagonistic activity. Sci Rep, 2019. 9(1): p. 2634.
5Ghodrati, M., E. Zavitz, M.G.P. Rosa, and N.S.C. Price, Contrast and luminance adaptation alter neuronal coding and perception of stimulus orientation. Nat Commun, 2019. 10(1): p. 941.
6Good-Jacobson, K.L., B cells turn on, tune in with LSD1. Nat Immunol, 2019. 20(1): p. 3-5.
7Goulas, A., P. Majka, M.G.P. Rosa, and C.C. Hilgetag, A blueprint of mammalian cortical connectomes. PLoS Biol, 2019. 17(3): p. e2005346.
8Haqshenas, G., G. Terradas, P.N. Paradkar, J.B. Duchemin, E.A. McGraw, and C. Doerig, A Role for the Insulin Receptor in the Suppression of Dengue Virus and Zika Virus in Wolbachia-Infected Mosquito Cells. Cell Rep, 2019. 26(3): p. 529-535.e3.
9Harrison, P.F., A.D. Pattison, D.R. Powell, and T.H. Beilharz, Topconfects: a package for confident effect sizes in differential expression analysis provides a more biologically useful ranked gene list. Genome Biol, 2019. 20(1): p. 67.
10Izore, T., J. Tailhades, M.H. Hansen, J.A. Kaczmarski, C.J. Jackson, and M.J. Cryle, Drosophila melanogaster nonribosomal peptide synthetase Ebony encodes an atypical condensation domain. Proc Natl Acad Sci U S A, 2019. 116(8): p. 2913-2918.
11Jiang, J.H., M.S. Bhuiyan, H.H. Shen, D.R. Cameron, T.W.T. Rupasinghe, C.M. Wu, A.P. Le Brun, X. Kostoulias, C. Domene, A.J. Fulcher, M.J. McConville, B.P. Howden, G.J. Lieschke, and A.Y. Peleg, Antibiotic resistance and host immune evasion in Staphylococcus aureus mediated by a metabolic adaptation. Proc Natl Acad Sci U S A, 2019. 116(9): p. 3722-3727.
12Koutsakos, M., P.T. Illing, T.H.O. Nguyen, N.A. Mifsud, J.C. Crawford, S. Rizzetto, A.A. Eltahla, E.B. Clemens, S. Sant, B.Y. Chua, C.Y. Wong, E.K. Allen, D. Teng, P. Dash, D.F. Boyd, L. Grzelak, W. Zeng, A.C. Hurt, I. Barr, S. Rockman, D.C. Jackson, T.C. Kotsimbos, A.C. Cheng, M. Richards, G.P. Westall, T. Loudovaris, S.I. Mannering, M. Elliott, S.G. Tangye, L.M. Wakim, J. Rossjohn, D. Vijaykrishna, F. Luciani, P.G. Thomas, S. Gras, A.W. Purcell, and K. Kedzierska, Human CD8+ T cell cross-reactivity across influenza A, B and C viruses. Nature Immunology, 2019.
13Lee, C.J., D.W. Smith, B.S. Gardiner, and R.G. Evans, Stimulation of erythropoietin release by hypoxia and hypoxemia: similar but different. Kidney Int, 2019. 95(1): p. 23-25.
14Ma, X., L. Zhang, J. Song, E. Nguyen, R.S. Lee, S.J. Rodgers, F. Li, C. Huang, R.B. Schittenhelm, H. Chan, C. Chheang, J. Wu, K.K. Brown, C.A. Mitchell, K.J. Simpson, and R.J. Daly, Characterization of the Src-regulated kinome identifies SGK1 as a key mediator of Src-induced transformation. Nat Commun, 2019. 10(1): p. 296.
15Padman, B.S., T.N. Nguyen, L. Uoselis, M. Skulsuppaisarn, L.K. Nguyen, and M. Lazarou, LC3/GABARAPs drive ubiquitin-independent recruitment of Optineurin and NDP52 to amplify mitophagy. Nat Commun, 2019. 10(1): p. 408.
16Sakaue, H., T. Shiota, N. Ishizaka, S. Kawano, Y. Tamura, K.S. Tan, K. Imai, C. Motono, T. Hirokawa, K. Taki, N. Miyata, O. Kuge, T. Lithgow, and T. Endo, Porin Associates with Tom22 to Regulate the Mitochondrial Protein Gate Assembly. Mol Cell, 2019. 73(5): p. 1044-1055.e8.
17Scheer, S., S. Ackloo, T.S. Medina, M. Schapira, F. Li, J.A. Ward, A.M. Lewis, J.P. Northrop, P.L. Richardson, H.U. Kaniskan, Y. Shen, J. Liu, D. Smil, D. McLeod, C.A. Zepeda-Velazquez, M. Luo, J. Jin, D. Barsyte-Lovejoy, K.V.M. Huber, D.D. De Carvalho, M. Vedadi, C. Zaph, P.J. Brown, and C.H. Arrowsmith, A chemical biology toolbox to study protein methyltransferases and epigenetic signaling. Nat Commun, 2019. 10(1): p. 19
18Schoppet, M., M. Peschke, A. Kirchberg, V. Wiebach, R.D. Sussmuth, E. Stegmann, and M.J. Cryle, The biosynthetic implications of late-stage condensation domain selectivity during glycopeptide antibiotic biosynthesis. Chem Sci, 2019. 10(1): p. 118-133.
19Shahine, A., P. Reinink, J.F. Reijneveld, S. Gras, M. Holzheimer, T.Y. Cheng, A.J. Minnaard, J.D. Altman, S. Lenz, J. Prandi, J. Kubler-Kielb, D.B. Moody, J. Rossjohn, and I. Van Rhijn, A T-cell receptor escape channel allows broad T-cell response to CD1b and membrane phospholipids. Nat Commun, 2019. 10(1): p. 56.
20Taylor, R.A., M. Fraser, R.J. Rebello, P.C. Boutros, D.G. Murphy, R.G. Bristow, and G.P. Risbridger, The influence of BRCA2 mutation on localized prostate cancer. Nat Rev Urol, 2019.
21Watt, M.J., A.K. Clark, L.A. Selth, V.R. Haynes, N. Lister, R. Rebello, L.H. Porter, B. Niranjan, S.T. Whitby, J. Lo, C. Huang, R.B. Schittenhelm, K.E. Anderson, L. Furic, P.R. Wijayaratne, M. Matzaris, M.K. Montgomery, M. Papargiris, S. Norden, M. Febbraio, G.P. Risbridger, M. Frydenberg, D.K. Nomura, and R.A. Taylor, Suppressing fatty acid uptake has therapeutic effects in preclinical models of prostate cancer. Sci Transl Med, 2019. 11(478).
22Torpe, N., S. Gopal, O. Baltaci, L. Rella, A. Handley, H.C. Korswagen, and R. Pocock, A Protein Disulfide Isomerase Controls Neuronal Migration through Regulation of Wnt Secretion. Cell Rep, 2019. 26(12): p. 3183-3190.e5
23Zhang, Q., N.J. McKenzie, R. Warneford-Thomson, E.H. Gail, S.F. Flanigan, B.M. Owen, R. Lauman, V. Levina, B.A. Garcia, R.B. Schittenhelm, R. Bonasio, and C. Davidovich, RNA exploits an exposed regulatory site to inhibit the enzymatic activity of PRC2. Nat Struct Mol Biol, 2019. 26(3): p. 237-247
1Balaji, G.R., O.A. Aguilar, M. Tanaka, M.A. Shingu-Vazquez, Z. Fu, B.S. Gully, L.L. Lanier, J.R. Carlyle, J. Rossjohn, and R. Berry, Recognition of host Clr-b by the inhibitory NKR-P1B receptor provides a basis for missing-self recognition. Nat Commun, 2018. 9(1): p. 4623.
2 Burrows, K., F. Antignano, A. Chenery, M. Bramhall, V. Korinek, T.M. Underhill, and C. Zaph, HIC1 links retinoic acid signalling to group 3 innate lymphoid cell-dependent regulation of intestinal immunity and homeostasis. PLoS Pathog, 2018. 14(2): p. e1006869.
3Chan, K.F., B.S. Gully, S. Gras, D.X. Beringer, L. Kjer-Nielsen, J. Cebon, J. McCluskey, W. Chen, and J. Rossjohn, Divergent T-cell receptor recognition modes of a HLA-I restricted extended tumour-associated peptide. Nat Commun, 2018. 9(1): p. 1026.
4 Chen, Z., P. Zhao, F. Li, A. Leier, T.T. Marquez-Lago, Y. Wang, G.I. Webb, A.I. Smith, R.J. Daly, K.C. Chou, and J. Song, iFeature: a python package and web server for features extraction
5 Chennamadhavuni, D., N.A. Saavedra-Avila, L.J. Carreno, M.J. Guberman-Pfeffer, P. Arora, T. Yongqing, R. Pryce, H.F. Koay, D.I. Godfrey, S. Keshipeddy, S.K. Richardson, S. Sundararaj, J.H. Lo, X. Wen, J.A. Gascon, W. Yuan, J. Rossjohn, J. Le Nours, S.A. Porcelli, and A.R. Howell, Dual Modifications of alpha-Galactosylceramide Synergize to Promote Activation of Human Invariant Natural Killer T Cells and Stimulate Anti-tumor Immunity. Cell Chem Biol, 2018. 25(5): p. 571-584.e8.
6 Christofferson, A.J., Z.S. Al-Garawi, N. Todorova, J. Turner, M.P. Del Borgo, L.C. Serpell, M.-I. Aguilar, and I. Yarovsky, Identifying the Coiled-Coil Triple Helix Structure of β-Peptide Nanofibers at Atomic Resolution. ACS Nano, 2018. 12(9): p. 9101-9109.
7Colafella, K.M.M. and K.M. Denton, Sex-specific differences in hypertension and associated cardiovascular disease. Nat Rev Nephrol, 2018. 14(3): p. 185-201.
8Davis, G.M., S. Tu, J.W. Anderson, R.N. Colson, M.J. Gunzburg, M.A. Francisco, D. Ray, S.P. Shrubsole, J.A. Sobotka, U. Seroussi, R.X. Lao, T. Maity, M.Z. Wu, K. McJunkin, Q.D. Morris, T.R. Hughes, J.A. Wilce, J.M. Claycomb, Z. Weng, and P.R. Boag, The TRIM-NHL protein NHL-2 is a co-factor in the nuclear and somatic RNAi pathways in C. elegans. Elife, 2018. 7.
9Deo, P., S.H. Chow, I.D. Hay, O. Kleifeld, A. Costin, K.D. Elgass, J.H. Jiang, G. Ramm, K. Gabriel, G. Dougan, T. Lithgow, E. Heinz, and T. Naderer, Outer membrane vesicles from Neisseria gonorrhoeae target PorB to mitochondria and induce apoptosis. PLoS Pathog, 2018. 14(3): p. e1006945.
10Dodd, G.T., N.J. Michael, R.S. Lee-Young, S.P. Mangiafico, J.T. Pryor, A.C. Munder, S.E. Simonds, J.C. Bruning, Z.Y. Zhang, M.A. Cowley, S. Andrikopoulos, T.L. Horvath, D. Spanswick, and T. Tiganis, Insulin regulates POMC neuronal plasticity to control glucose metabolism. Elife, 2018. 7.
11Evans, R.G. and C.P.C. Ow, Heterogeneity of renal cortical oxygenation: seeing is believing. Kidney Int, 2018. 93(6): p. 1278-1280.
12Faridi, P., C. Li, S.H. Ramarathinam, J.P. Vivian, P.T. Illing, N.A. Mifsud, R. Ayala, J. Song, L.J. Gearing, P.J. Hertzog, N. Ternette, J. Rossjohn, N.P. Croft, and A.W. Purcell, A subset of HLA-I peptides are not genomically templated: Evidence for cis- and trans-spliced peptide ligands. Sci Immunol, 2018. 3(28).
13 Forrester, J.V., P.G. McMenamin, and S.J. Dando, CNS infection and immune privilege. Nat Rev Neurosci, 2018. 19(11): p. 655-671.
14 Galperin, M., C. Farenc, M. Mukhopadhyay, D. Jayasinghe, A. Decroos, D. Benati, L.L. Tan, L. Ciacchi, H.H. Reid, J. Rossjohn, L.A. Chakrabarti, and S. Gras, CD4(+) T cell-mediated HLA class II cross-restriction in HIV controllers. Sci Immunol, 2018. 3(24).
15Garriga, D., S. Headey, C. Accurso, M. Gunzburg, M. Scanlon, and F. Coulibaly, Structural basis for the inhibition of poxvirus assembly by the antibiotic rifampicin. Proc Natl Acad Sci U S A, 2018. 115(33): p. 8424-8429.
16 Godfrey, D.I., J. Le Nours, D.M. Andrews, A.P. Uldrich, and J. Rossjohn, Unconventional T Cell Targets for Cancer Immunotherapy. Immunity, 2018. 48(3): p. 453-473.
17Grant, E.J., T.M. Josephs, L. Loh, E.B. Clemens, S. Sant, M. Bharadwaj, W. Chen, J. Rossjohn, S. Gras, and K. Kedzierska, Broad CD8(+) T cell cross-recognition of distinct influenza A strains in humans. Nat Commun, 2018. 9(1): p. 5427.
18Greule, A., J.E. Stok, J.J. De Voss, and M.J. Cryle, Unrivalled diversity: the many roles and reactions of bacterial cytochromes P450 in secondary metabolism. Nat Prod Rep, 2018. doi: 10.1039/c7np00063d.
19Grinter, R., I.D. Hay, J. Song, J. Wang, D. Teng, V. Dhanesakaran, J.J. Wilksch, M.R. Davies, D. Littler, S.A. Beckham, I.R. Henderson, R.A. Strugnell, G. Dougan, and T. Lithgow, FusC, a member of the M16 protease family acquired by bacteria for iron piracy against plants. PLoS Biol, 2018. 16(8): p. e2006026.
20Grohmann, M., F. Wiede, G.T. Dodd, E.N. Gurzov, G.J. Ooi, T. Butt, A.A. Rasmiena, S. Kaur, T. Gulati, P.K. Goh, A.E. Treloar, S. Archer, W.A. Brown, M. Muller, M.J. Watt, O. Ohara, C.A. McLean, and T. Tiganis, Obesity Drives STAT-1-Dependent NASH and STAT-3-Dependent HCC. Cell, 2018. 175(5): p. 1289-1306.e20.
21Gunasinghe, S.D., T. Shiota, C.J. Stubenrauch, K.E. Schulze, C.T. Webb, A.J. Fulcher, R.A. Dunstan, I.D. Hay, T. Naderer, D.R. Whelan, T.D.M. Bell, K.D. Elgass, R.A. Strugnell, and T. Lithgow, The WD40 Protein BamB Mediates Coupling of BAM Complexes into Assembly Precincts in the Bacterial Outer Membrane. Cell Rep, 2018. 23(9): p. 2782-2794.
22 Hankir, M.K., F. Seyfried, A.D. Miras, and M.A. Cowley, Brain Feeding Circuits after Roux-en-Y Gastric Bypass. Trends Endocrinol Metab, 2018. 29(4): p. 218-237.
23Illing, P.T., P. Pymm, N.P. Croft, H.G. Hilton, V. Jojic, A.S. Han, J.L. Mendoza, N.A. Mifsud, N.L. Dudek, J. McCluskey, P. Parham, J. Rossjohn, J.P. Vivian, and A.W. Purcell, HLA-B57 micropolymorphism defines the sequence and conformational breadth of the immunopeptidome. Nat Commun, 2018. 9(1): p. 4693.
24 Kamerkar, S.C., F. Kraus, A.J. Sharpe, T.J. Pucadyil, and M.T. Ryan, Dynamin-related protein 1 has membrane constricting and severing abilities sufficient for mitochondrial and peroxisomal fission. Nat Commun, 2018. 9(1): p. 5239.
25Knoblich, K., S. Cruz Migoni, S.M. Siew, E. Jinks, B. Kaul, H.C. Jeffery, A.T. Baker, M. Suliman, K. Vrzalikova, H. Mehenna, P.G. Murray, F. Barone, Y.H. Oo, P.N. Newsome, G. Hirschfield, D. Kelly, S.P. Lee, B. Parekkadan, S.J. Turley, and A.L. Fletcher, The human lymph node microenvironment unilaterally regulates T-cell activation and differentiation. PLoS Biol, 2018. 16(9): p. e2005046.
26Koch, B., A.A. Barugahare, T.L. Lo, C. Huang, R.B. Schittenhelm, D.R. Powell, T.H. Beilharz, and A. Traven, A Metabolic Checkpoint for the Yeast-to-Hyphae Developmental Switch Regulated by Endogenous Nitric Oxide Signaling. Cell Rep, 2018. 25(8): p. 2244-2258.e7.
27La, H.M., J.A. Makela, A.L. Chan, F.J. Rossello, C.M. Nefzger, J.M.D. Legrand, M. De Seram, J.M. Polo, and R.M. Hobbs, Identification of dynamic undifferentiated cell states within the male germline. Nat Commun, 2018. 9(1): p. 2819.
28La Gruta, N.L., S. Gras, S.R. Daley, P.G. Thomas, and J. Rossjohn, Understanding the drivers of MHC restriction of T cell receptors. Nat Rev Immunol, 2018. 18(7): p. 467-478.
29Lam, M., S.G. Royce, C.S. Samuel, and J.E. Bourke, Serelaxin as a novel therapeutic opposing fibrosis and contraction in lung diseases. Pharmacol Ther, 2018. 187: p. 61-70.
30Lawrence, M.G., D. Obinata, S. Sandhu, L.A. Selth, S.Q. Wong, L.H. Porter, N. Lister, D. Pook, C.J. Pezaro, D.L. Goode, R.J. Rebello, A.K. Clark, M. Papargiris, J. Van Gramberg, A.R. Hanson, P. Banks, H. Wang, B. Niranjan, S. Keerthikumar, S. Hedwards, A. Huglo, R. Yang, C. Henzler, Y. Li, F. Lopez-Campos, E. Castro, R. Toivanen, A. Azad, D. Bolton, J. Goad, J. Grummet, L. Harewood, J. Kourambas, N. Lawrentschuk, D. Moon, D.G. Murphy, S. Sengupta, R. Snow, H. Thorne, C. Mitchell, J. Pedersen, D. Clouston, S. Norden, A. Ryan, S.M. Dehm, W.D. Tilley, R.B. Pearson, R.D. Hannan, M. Frydenberg, L. Furic, R.A. Taylor, and G.P. Risbridger, Patient-derived Models of Abiraterone- and Enzalutamide-resistant Prostate Cancer Reveal Sensitivity to Ribosome-directed Therapy. Eur Urol, 2018.
31Lee, T.-H., D.J. Hirst, K. Kulkarni, M.P. Del Borgo, and M.-I. Aguilar, Exploring Molecular-Biomembrane Interactions with Surface Plasmon Resonance and Dual Polarization Interferometry Technology: Expanding the Spotlight onto Biomembrane Structure. Chemical Reviews, 2018. 118(11): p. 5392-5487.
32Li, F., C. Li, T.T. Marquez-Lago, A. Leier, T. Akutsu, A.W. Purcell, A.I. Smith, T. Lithgow, R.J. Daly, J. Song, and K.C. Chou, Quokka: a comprehensive tool for rapid and accurate prediction of kinase family-specific phosphorylation sites in the human proteome. Bioinformatics, 2018.
33Low, L.Y., P.F. Harrison, J. Gould, D.R. Powell, J.M. Choo, S.C. Forster, R. Chapman, L.J. Gearing, J.K. Cheung, P. Hertzog, and J.I. Rood, Concurrent Host-Pathogen Transcriptional Responses in a Clostridium perfringens Murine Myonecrosis Infection. MBio, 2018. 9(2).
34Manning, S.A., L.G. Dent, S. Kondo, Z.W. Zhao, N. Plachta, and K.F. Harvey, Dynamic Fluctuations in Subcellular Localization of the Hippo Pathway Effector Yorkie In Vivo. Curr Biol, 2018. 28(10): p. 1651-1660.e4.
35McArthur, K. and B.T. Kile, Apoptotic Caspases: Multiple or Mistaken Identities? Trends Cell Biol, 2018. 28(6): p. 475-493.
36McArthur, K., L.W. Whitehead, J.M. Heddleston, L. Li, B.S. Padman, V. Oorschot, N.D. Geoghegan, S. Chappaz, S. Davidson, H. San Chin, R.M. Lane, M. Dramicanin, T.L. Saunders, C. Sugiana, R. Lessene, L.D. Osellame, T.L. Chew, G. Dewson, M. Lazarou, G. Ramm, G. Lessene, M.T. Ryan, K.L. Rogers, M.F. van Delft, and B.T. Kile, BAK/BAX macropores facilitate mitochondrial herniation and mtDNA efflux during apoptosis. Science, 2018. 359(6378).
37McArthur, K., S. Chappaz, and B.T. Kile, Apoptosis in megakaryocytes and platelets: the life and death of a lineage. Blood, 2018. 131(6): p. 605-610.
38Montgomery, M.K., R. Mokhtar, J. Bayliss, H.C. Parkington, V.M. Suturin, C.R. Bruce, and M.J. Watt, Perilipin 5 Deletion Unmasks an Endoplasmic Reticulum Stress-Fibroblast Growth Factor 21 Axis in Skeletal Muscle. Diabetes, 2018. 67(4): p. 594-606.
39 Pidsley, R., M.G. Lawrence, E. Zotenko, B. Niranjan, A. Statham, J. Song, R.M. Chabanon, W. Qu, H. Wang, M. Richards, S.S. Nair, N.J. Armstrong, H.T. Nim, M. Papargiris, P. Balanathan, H. French, T. Peters, S. Norden, A. Ryan, J. Pedersen, J. Kench, R.J. Daly, L.G. Horvath, P. Stricker, M. Frydenberg, R.A. Taylor, C. Stirzaker, G.P. Risbridger, and S.J. Clark, Enduring epigenetic landmarks define the cancer microenvironment. Genome Res, 2018. 28(5): p. 625-638.
40 Poon, C.L.C., W. Liu, Y. Song, M. Gomez, Y. Kulaberoglu, X. Zhang, W. Xu, A. Veraksa, A. Hergovich, A. Ghabrial, and K.F. Harvey, A Hippo-like Signaling Pathway Controls Tracheal Morphogenesis in Drosophila melanogaster. Dev Cell, 2018. 47(5): p. 564-575.e5.
41Quinn, K.M., A. Fox, K.L. Harland, B.E. Russ, J. Li, T.H.O. Nguyen, L. Loh, M. Olshanksy, H. Naeem, K. Tsyganov, F. Wiede, R. Webster, C. Blyth, X.Y.X. Sng, T. Tiganis, D. Powell, P.C. Doherty, S.J. Turner, K. Kedzierska, and N.L. La Gruta, Age-Related Decline in Primary CD8(+) T Cell Responses Is Associated with the Development of Senescence in Virtual Memory CD8(+) T Cells. Cell Rep, 2018. 23(12): p. 3512-3524.
42Rabi, R., S. Larcombe, R. Mathias, S. McGowan, M. Awad, and D. Lyras, Clostridium sordellii outer spore proteins maintain spore structural integrity and promote bacterial clearance from the gastrointestinal tract. PLoS Pathog, 2018. 14(4): p. e1007004.
43Ratnadiwakara, M., S.K. Archer, C.I. Dent, I. Ruiz De Los Mozos, T.H. Beilharz, A.S. Knaupp, C.M. Nefzger, J.M. Polo, and M.L. Anko, SRSF3 promotes pluripotency through Nanog mRNA export and coordination of the pluripotency gene expression program. Elife, 2018. 7.
44Rawlinson, S.M., T. Zhao, A.M. Rozario, C.L. Rootes, P.J. McMillan, A.W. Purcell, A. Woon, G.A. Marsh, K.G. Lieu, L.F. Wang, H.J. Netter, T.D.M. Bell, C.R. Stewart, and G.W. Moseley, Viral regulation of host cell biology by hijacking of the nucleolar DNA-damage response. Nat Commun, 2018. 9(1): p. 3057.
45Reichenbach, A., R. Stark, M. Mequinion, R.R.G. Denis, J.F. Goularte, R.E. Clarke, S.H. Lockie, M.B. Lemus, G.M. Kowalski, C.R. Bruce, C. Huang, R.B. Schittenhelm, R.L. Mynatt, B.J. Oldfield, M.J. Watt, S. Luquet, and Z.B. Andrews, AgRP Neurons Require Carnitine Acetyltransferase to Regulate Metabolic Flexibility and Peripheral Nutrient Partitioning. Cell Rep, 2018. 22(7): p. 1745-1759.
46Shin, S.Y., A.K. Muller, N. Verma, S. Lev, and L.K. Nguyen, Systems modelling of the EGFR-PYK2-c-Met interaction network predicts and prioritizes synergistic drug combinations for triple-negative breast cancer. PLoS Comput Biol, 2018. 14(6): p. e1006192.
47Short, K.M., A. Combes, V. Lisnyak, J. Lefevre, L. Jones, M.H. Little, N. Hamilton, and I.M. Smyth, Branching morphogenesis in the developing kidney is not impacted by nephron formation or integration. Elife, 2018. 7.
48Song, J., F. Li, A. Leier, T.T. Marquez-Lago, T. Akutsu, G. Haffari, K.C. Chou, G.I. Webb, R.N. Pike, and J. Hancock, PROSPERous: high-throughput prediction of substrate cleavage sites for 90 proteases with improved accuracy. Bioinformatics, 2018. 34(4): p. 684-687.
49Spicer, B.A., R.H.P. Law, T.T. Caradoc-Davies, S.M. Ekkel, C. Bayly-Jones, S.S. Pang, P.J. Conroy, G. Ramm, M. Radjainia, H. Venugopal, J.C. Whisstock, and M.A. Dunstone, The first transmembrane region of complement component-9 acts as a brake on its self-assembly. Nat Commun, 2018. 9(1): p. 3266.
50Sundararaj, S., J. Zhang, S.H. Krovi, R. Bedel, K.D. Tuttle, N. Veerapen, G.S. Besra, Y. Khandokar, T. Praveena, J. Le Nours, J.L. Matsuda, J. Rossjohn, and L. Gapin, Differing roles of CD1d2 and CD1d1 proteins in type I natural killer T cell development and function. Proc Natl Acad Sci U S A, 2018. 115(6): p. E1204-e1213.
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1Bird, C.H., M.E. Christensen, M.S. Mangan, M.D. Prakash, K.A. Sedelies, M.J. Smyth, I. Harper, N.J. Waterhouse and P.I. Bird, The granzyme B-Serpinb9 axis controls the fate of lymphocytes after lysosomal stress. Cell Death Differ, 2014. 21: p. 876-887 Category: Biochemistry & Molecular Biology Impact Factor: 8.385 Ranking: 25/291.

Borg, M.L., M. Lemus, A. Reichenbach, A. Selathurai, B.J. Oldfield, Z.B. Andrews and M.J. Watt, Hypothalamic neurogenesis is not required for the improved insulin sensitivity following exercise training. Diabetes, 2014. 63(11): p. 3647-3658 Category: Endocrinology & Metabolism. Impact Factor: 8.474 Ranking: 6/123.

3 Boyd, A.W., P.F. Bartlett and M. Lackmann, Therapeutic targeting of EPH receptors and their ligands. Nat Rev Drug Discov, 2014. 13(1): p. 39-62 Category: Biotechnology & Applied Microbiology Impact Factor: 37.231 Ranking: 2/165.
4 Chow, B.S., M. Kocan, S. Bosnyak, M. Sarwar, B. Wigg, E.S. Jones, R.E. Widdop, R.J. Summers, R.A. Bathgate, T.D. Hewitson and C.S. Samuel, Relaxin requires the angiotensin II type 2 receptor to abrogate renal interstitial fibrosis. Kidney Int, 2014. 86(1): p. 75-85 Category: Urology & Nephrology Impact Factor: 8.520 Ranking: 3/75.
5 Corbett, A.J., S.B. Eckle, R.W. Birkinshaw, L. Liu, O. Patel, J. Mahony, Z. Chen, R. Reantragoon, B. Meehan, H. Cao, N.A. Williamson, R.A. Strugnell, D. Van Sinderen, J.Y. Mak, D.P. Fairlie, L. Kjer-Nielsen, J. Rossjohn and J. McCluskey, T-cell activation by transitory neo-antigens derived from distinct microbial pathways. Nature, 2014. 509: p. 361-365 Category: Multidisciplinary Sciences Impact Factor: 42.351 Ranking: 1/55.
6DiTommaso, T., D.L. Cottle, H.B. Pearson, H. Schluter, P. Kaur, P.O. Humbert and I.M. Smyth, Keratin 76 is required for tight junction function and maintenance of the skin barrier. PLoS Genet, 2014. 10(10):     p.     e1004706.1-13     Category:     Genetics     &     Heredity Impact Factor: 8.167 Ranking:     14/165.
7DiTommaso, T., L.K. Jones, D.L. Cottle, W.M.G. Program, A.K. Gerdin, V.E. Vancollie, F.M. Watt, R. Ramirez-Solis, A. Bradley, K.P. Steel, J.P. Sundberg, J.K. White and I.M. Smyth, Identification of genes important for cutaneous function revealed by a large scale reverse genetic screen in the mouse. PLoS Genet, 2014. 10(10): p. e1004705.1-12 Category: Genetics & Heredity Impact Factor: 8.167 Ranking: 14/165.

Eckle, S.B., R.W. Birkinshaw, L. Kostenko, A.J. Corbett, H.E. McWilliam, R. Reantragoon, Z. Chen, N.A. Gherardin, T. Beddoe, L. Liu, O. Patel, B. Meehan, D.P. Fairlie, J.A. Villadangos, D.I. Godfrey, L. Kjer-Nielsen, J. McCluskey and J. Rossjohn, A molecular basis underpinning the T cell receptor heterogeneity of mucosal-associated invariant T cells. J Exp Med, 2014. 211(8): p. 1585-1600 Category: Immunology impact Factor: 13.912 Ranking: 5/144.


Ellem, S.J., E.M. De-Juan-Pardo and G.P. Risbridger, In vitro modeling of the prostate cancer microenvironment. Adv Drug Deliv Rev, 2014. 79-80: p. 214-221 Category: Pharmacology & Pharmacy Impact Factor: 12.707 Ranking: 4/254.


Gurzov, E.N., M. Tran, M.A. Fernandez-Rojo, T.L. Merry, X. Zhang, Y. Xu, A. Fukushima, M.J. Waters, M.J. Watt, S. Andrikopoulos, B.G. Neel and T. Tiganis, Hepatic Oxidative Stress Promotes Insulin-STAT-5 Signaling and Obesity by Inactivating Protein Tyrosine Phosphatase N2. Cell Metab, 2014. 20(1): p. 85-102 Category: Cell Biology Impact Factor: 16.747 Ranking: 8/185.

11 Henstridge, M.A., T.K. Johnson, C.G. Warr and J.C. Whisstock, Trunk cleavage is essential for Drosophila terminal patterning and can occur independently of Torso-like. Nat Commun, 2014. 5: p. 3419.1-7 Category: Multidisciplinary     Sciences Impact Factor: 10.742 Ranking:     3/55.
12Kass, I., D.E. Hoke, M.G. Costa, C.F. Reboul, B.T. Porebski, N.P. Cowieson, H. Leh, E. Pennacchietti, J. McCoey, O. Kleifeld, C. Borri Voltattorni, D. Langley, B. Roome, I.R. Mackay, D. Christ,     D.     Perahia,     M.     Buckle,     A.     Paiardini,     D.     De     Biase     and A.M. Buckle, Cofactor-dependent conformational heterogeneity of GAD65 and its role in autoimmunity and neurotransmitter homeostasis. Proc Natl Acad Sci U S A, 2014. 111(25): p. E2524-2529     Category:     Multidisciplinary     Sciences Impact Factor: 9.809 Ranking:     4/55.
13Leyton, D.L., M.D. Johnson, R. Thapa, G.H. Huysmans, R.A. Dunstan, N. Celik, H.H. Shen, D. Loo, M.J. Belousoff, A.W. Purcell, I.R. Henderson, T. Beddoe, J. Rossjohn,     L.L.     Martin,     R.A.     Strugnell     and T. Lithgow, A mortise-tenon joint in the transmembrane domain modulates autotransporter assembly into bacterial outer membranes. Nat Commun, 2014. 5: p. 4239.1-11 Category: Multidisciplinary Sciences Impact Factor: 10.742 Ranking:     3/55.
14Lieu, K.G., E.H. Shim, J. Wang, R.K. Lokareddy, T. Tao, G. Cingolani, G.P. Zambetti and D.A. Jans, The p53-induced factor Ei24 inhibits nuclear import through an importin beta-binding-like domain. J Cell Biol, 2014. 205(3):     p.     301-312     Category:     Cell     Biology Impact Factor: 9.688 Ranking:     21/185.
15 Nabti, I., P. Marangos, J. Bormann, N.R. Kudo and J. Carroll, Dual-mode regulation of the APC/C by CDK1 and MAPK controls meiosis I progression and fidelity. J Cell Biol, 2014. 204(6): p. 891-900 Category: Cell Biology Impact Factor: 9.688 Ranking: 21/185.
16Parkington, H.C., J. Stevenson, M.A. Tonta, J. Paul, T. Butler, K. Maiti, E.C. Chan, P.M. Sheehan, S.P. Brennecke, H.A. Coleman and R. Smith, Diminished hERG K+ channel activity facilitates strong human labour contractions but is dysregulated in obese women. Nat Commun, 2014. 5(Article #4108): p. 1-8 Category: Multidisciplinary Sciences Impact Factor: 10.742 Ranking: 3/55.
17 Pellicci, D.G., A.P. Uldrich, J. Le Nours, F. Ross, E. Chabrol, S.B. Eckle, R. de Boer, R.T. Lim, K. McPherson, G. Besra, A.R. Howell, L. Moretta, J. McCluskey, M.H. Heemskerk, S. Gras, J. Rossjohn and D.I. Godfrey, The molecular bases of delta/alphabeta T cell-mediated antigen recognition. J Exp Med, 2014. 211(13): p. 2599-2615 Category: Immunology Impact Factor: 13.912 Ranking: 5/144.
18Petersen, J., V. Montserrat, J.R. Mujico, K.L. Loh, D.X. Beringer, M. van Lummel, A. Thompson, M.L. Mearin, J. Schweizer, Y. Kooy-Winkelaar, J. van Bergen, J.W. Drijfhout, W.T. Kan, N.L. La Gruta, R.P. Anderson, H.H. Reid, F. Koning and J. Rossjohn, T-cell receptor recognition of HLA-DQ2-gliadin complexes associated with celiac disease. Nat Struct Mol Biol, 2014. 21(5): p. 480-490 Category: Biochemistry & Molecular Biology Impact Factor: 11.633 Ranking: 14/291.
19Prakash, M.D., M.A. Munoz, R. Jain, P.L. Tong, A. Koskinen, M. Regner, O. Kleifeld, B. Ho, M. Olson, S.J. Turner, P. Mrass, W. Weninger and P.I. Bird, Granzyme B promotes cytotoxic lymphocyte transmigration via basement membrane remodeling. Immunity, 2014. 41(6): p. 960-972 Category: Immunology Impact Factor: 19.748 Ranking: 4/144.
20Shen, H.H., D.L. Leyton, T. Shiota, M.J. Belousoff, N. Noinaj, J. Lu, S.A. Holt, K. Tan, J. Selkrig, C.T. Webb, S.K. Buchanan, L.L. Martin and T. Lithgow, Reconstitution of a nanomachine driving the assembly of proteins into bacterial outer membranes. Nat Commun, 2014. 5(5078): p. 1-10 Category: Multidisciplinary Sciences Impact Factor: 10.742 Ranking: 3/55.
21Short, K.M., A.N. Combes, J. Lefevre, A.L. Ju, K.M. Georgas, T. Lamberton, O. Cairncross, B.A. Rumballe, A.P. McMahon, N.A. Hamilton, I.M. Smyth and M.H. Little, Global quantification of tissue dynamics in the developing mouse kidney. Dev Cell, 2014. 29(2):     p.     188-202     Category:     Cell     Biology Impact Factor: 10.366 Ranking:     17/185.
22Simonds, S.E., J.T. Pryor, E. Ravussin, F.L. Greenway, R. Dileone, A.M. Allen, J. Bassi, J.K. Elmquist, J.M. Keogh, E. Henning, M.G. Myers, Jr., J. Licinio, R.D. Brown, P.J. Enriori, S. O'Rahilly, S.M. Sternson, K.L. Grove, D.C. Spanswick,     I.S.     Farooqi     and M.A. Cowley, Leptin mediates the increase in blood pressure associated with obesity. Cell, 2014. 159(6): p. 1404-1416 Category: Biochemistry & Molecular Biology Impact Factor: 33.116 Ranking: 1/291.
23Teoh, S.S., J. Vieusseux, M. Prakash, S. Berkowicz, J. Luu, C.H. Bird, R.H. Law, C. Rosado, J.T. Price, J.C. Whisstock and P.I. Bird, Maspin is not required for embryonic development or tumour suppression. Nat Commun, 2014. 5: p. 3164.1-9 Category: Multidisciplinary Sciences Impact Factor: 10.742 Ranking: 3/55.
24Vail, M.E., C. Murone, A. Tan, L. Hii, D. Abebe, P.W. Janes, F.T. Lee, M. Baer, V. Palath, C. Bebbington, G. Yarranton, C. Llerena, S. Garic, D. Abramson, G. Cartwright, A.M. Scott and M. Lackmann, Targeting EphA3 Inhibits Cancer Growth by Disrupting the Tumor Stromal Microenvironment. Cancer Res, 2014. 74(16): p. 4470-4481 Category: Oncology Impact Factor: 9.284 Ranking: 10/202.
25Wiede, F., N.L. La Gruta and T. Tiganis, PTPN2 attenuates T-cell lymphopenia-induced proliferation. Nat Commun, 2014. 5: p. 3073.1-15 Category: Multidisciplinary Sciences Impact Factor: 10.742 Ranking: 3/55.