Publication highlights

Typically in any given year our scientists publish in excess of 600 research papers and reviews. Here we provide a selection of their research highlights. 'Highlight' papers are those led by Biomedicine Discovery Institute scientists and represent original research, published in the top journals in the field.

As of September 2019.

View featured publications by year

2019 | 2018 | 2017 | 2016 | 2015 | 2014

1Andoniou CE, Schuster IS, Degli-Esposti MA (2019) The Avidity Game: Selecting Natural-Born Killers. Immunity 50: 1337-1339
2Balland E, Chen W, Dodd GT, Conductier G, Coppari R, Tiganis T, Cowley MA (2019) Leptin Signaling in the Arcuate Nucleus Reduces Insulin's Capacity to Suppress Hepatic Glucose Production in Obese Mice. Cell Rep 26: 346-355.e3
3 Chen Z, Zhao P, Li F, Marquez-Lago TT, Leier A, Revote J, Zhu Y, Powell DR, Akutsu T, Webb GI, Chou KC, Smith AI, Daly RJ, Li J, Song J (2019) iLearn: an integrated platform and meta-learner for feature engineering, machine-learning analysis and modeling of DNA, RNA and protein sequence data. Brief Bioinform bbz041,
4Cooper L, Good-Jacobson KL (2019) B Cells Hit a Class Ceiling in the Germinal Center. Immunity 51: 206-208
5Croft NP, Smith SA, Pickering J, Sidney J, Peters B, Faridi P, Witney MJ, Sebastian P, Flesch IEA, Heading SL, Sette A, La Gruta NL, Purcell AW, Tscharke DC (2019) Most viral peptides displayed by class I MHC on infected cells are immunogenic. Proc Natl Acad Sci U S A 116: 3112-3117
6 Cullen JG, McQuilten HA, Quinn KM, Olshansky M, Russ BE, Morey A, Wei S, Prier JE, La Gruta NL, Doherty PC, Turner SJ (2019) CD4(+) T help promotes influenza virus-specific CD8(+) T cell memory by limiting metabolic dysfunction. Proc Natl Acad Sci U S A
7 Cursons J, Souza-Fonseca-Guimaraes F, Foroutan M, Anderson A, Hollande F, Hediyeh-Zadeh S, Behren A, Huntington ND, Davis MJ (2019) A Gene Signature Predicting Natural Killer Cell Infiltration and Improved Survival in Melanoma Patients. Cancer Immunol Res 7: 1162-1174
8Edwards BA, Redline S, Sands SA, Owens RL (2019) More than the Sum of the Respiratory Events: Personalized Medicine Approaches for Obstructive Sleep Apnea. Am J Respir Crit Care Med
9Evans RG (2019) Another step forward for methods for studying renal oxygenation. Kidney Int 96: 552-554
10Ghodrati M, Zavitz E, Rosa MGP, Price NSC (2019) Contrast and luminance adaptation alter neuronal coding and perception of stimulus orientation. Nat Commun 10: 941
11Good-Jacobson KL (2019) B cells turn on, tune in with LSD1. Nat Immunol 20: 3-5
12 Goulas A, Majka P, Rosa MGP, Hilgetag CC (2019) A blueprint of mammalian cortical connectomes. PLoS Biol 17: e2005346
13Greule A, Izore T, Iftime D, Tailhades J, Schoppet M, Zhao Y, Peschke M, Ahmed I, Kulik A, Adamek M, Goode RJA, Schittenhelm RB, Kaczmarski JA, Jackson CJ, Ziemert N, Krenske EH, De Voss JJ, Stegmann E, Cryle MJ (2019) Kistamicin biosynthesis reveals the biosynthetic requirements for production of highly crosslinked glycopeptide antibiotics. Nat Commun 10: 2613
14Haqshenas G, Terradas G, Paradkar PN, Duchemin JB, McGraw EA, Doerig C (2019) A Role for the Insulin Receptor in the Suppression of Dengue Virus and Zika Virus in Wolbachia-Infected Mosquito Cells. Cell Rep 26: 529-535.e3
15 Harrison PF, Pattison AD, Powell DR, Beilharz TH (2019) Topconfects: a package for confident effect sizes in differential expression analysis provides a more biologically useful ranked gene list. Genome Biol 20: 67
16Hay ID, Lithgow T (2019) Filamentous phages: masters of a microbial sharing economy. EMBO Rep 20 (6). pii: e47427
17Izore T, Tailhades J, Hansen MH, Kaczmarski JA, Jackson CJ, Cryle MJ (2019) Drosophila melanogaster nonribosomal peptide synthetase Ebony encodes an atypical condensation domain. Proc Natl Acad Sci U S A 116: 2913-2918
18Jiang JH, Bhuiyan MS, Shen HH, Cameron DR, Rupasinghe TWT, Wu CM, Le Brun AP, Kostoulias X, Domene C, Fulcher AJ, McConville MJ, Howden BP, Lieschke GJ, Peleg AY (2019) Antibiotic resistance and host immune evasion in Staphylococcus aureus mediated by a metabolic adaptation. Proc Natl Acad Sci U S A 116: 3722-3727
19 Joannes-Boyau R, Adams JW, Austin C, Arora M, Moffat I, Herries AIR, Tonge MP, Benazzi S, Evans AR, Kullmer O, Wroe S, Dosseto A, Fiorenza L (2019) Elemental signatures of Australopithecus africanus teeth reveal seasonal dietary stress. Nature 572: 112-115
20 Koutsakos M, Illing PT, Nguyen THO, Mifsud NA, Crawford JC, Rizzetto S, Eltahla AA, Clemens EB, Sant S, Chua BY, Wong CY, Allen EK, Teng D, Dash P, Boyd DF, Grzelak L, Zeng W, Hurt AC, Barr I, Rockman S, Jackson DC, Kotsimbos TC, Cheng AC, Richards M, Westall GP, Loudovaris T, Mannering SI, Elliott M, Tangye SG, Wakim LM, Rossjohn J, Vijaykrishna D, Luciani F, Thomas PG, Gras S, Purcell AW, Kedzierska K (2019) Human CD8+ T cell cross-reactivity across influenza A, B and C viruses. Nature Immunology
21 Lankadeva YR, Cochrane AD, Marino B, Iguchi N, Hood SG, Bellomo R, May CN, Evans RG (2019) Strategies that improve renal medullary oxygenation during experimental cardiopulmonary bypass may mitigate postoperative acute kidney injury. Kidney Int 95: 1338-1346
22 Lee CJ, Smith DW, Gardiner BS, Evans RG (2019) Stimulation of erythropoietin release by hypoxia and hypoxemia: similar but different. Kidney Int 95: 23-25
23Legrand JMD, Chan AL, La HM, Rossello FJ, Anko ML, Fuller-Pace FV, Hobbs RM (2019) DDX5 plays essential transcriptional and post-transcriptional roles in the maintenance and function of spermatogonia. Nat Commun 10: 2278
24Li F, Fan C, Marquez-Lago TT, Leier A, Revote J, Jia C, Zhu Y, Smith AI, Webb GI, Liu Q, Wei L, Li J, Song J (2019) PRISMOID: a comprehensive 3D structure database for post-translational modifications and mutations with functional impact. Brief Bioinform bbz050, DOI: 10.1093/bib/bbz050
25Ma X, Zhang L, Song J, Nguyen E, Lee RS, Rodgers SJ, Li F, Huang C, Schittenhelm RB, Chan H, Chheang C, Wu J, Brown KK, Mitchell CA, Simpson KJ, Daly RJ (2019) Characterization of the Src-regulated kinome identifies SGK1 as a key mediator of Src-induced transformation. Nat Commun 10: 296
26Mei S, Li F, Leier A, Marquez-Lago TT, Giam K, Croft NP, Akutsu T, Smith AI, Li J, Rossjohn J, Purcell AW, Song J (2019) A comprehensive review and performance evaluation of bioinformatics tools for HLA class I peptide-binding prediction. Brief Bioinform Brief Bioinform bbz051 DOI: 10.1093/bib/bbz051
27Morris AP, Krekelberg B (2019) A Stable Visual World in Primate Primary Visual Cortex. Curr Biol 29: 1471-1480.e6
28Padman BS, Nguyen TN, Uoselis L, Skulsuppaisarn M, Nguyen LK, Lazarou M (2019) LC3/GABARAPs drive ubiquitin-independent recruitment of Optineurin and NDP52 to amplify mitophagy. Nat Commun 10: 408
29 Sakaue H, Shiota T, Ishizaka N, Kawano S, Tamura Y, Tan KS, Imai K, Motono C, Hirokawa T, Taki K, Miyata N, Kuge O, Lithgow T, Endo T (2019) Porin Associates with Tom22 to Regulate the Mitochondrial Protein Gate Assembly. Mol Cell 73: 1044-1055.e8
30Scheer S, Ackloo S, Medina TS, Schapira M, Li F, Ward JA, Lewis AM, Northrop JP, Richardson PL, Kaniskan HU, Shen Y, Liu J, Smil D, McLeod D, Zepeda-Velazquez CA, Luo M, Jin J, Barsyte-Lovejoy D, Huber KVM, De Carvalho DD, Vedadi M, Zaph C, Brown PJ, Arrowsmith CH (2019) A chemical biology toolbox to study protein methyltransferases and epigenetic signaling. Nat Commun 10: 19
31Schoppet M, Peschke M, Kirchberg A, Wiebach V, Sussmuth RD, Stegmann E, Cryle MJ (2019) The biosynthetic implications of late-stage condensation domain selectivity during glycopeptide antibiotic biosynthesis. Chem Sci 10: 118-133
32 Seruggia D, Oti M, Tripathi P, Canver MC, LeBlanc L, Di Giammartino DC, Bullen MJ, Nefzger CM, Sun YBY, Farouni R, Polo JM, Pinello L, Apostolou E, Kim J, Orkin SH, Das PP (2019) TAF5L and TAF6L Maintain Self-Renewal of Embryonic Stem Cells via the MYC Regulatory Network. Mol Cell 74: 1148-1163.e7
33Shahine A, Reinink P, Reijneveld JF, Gras S, Holzheimer M, Cheng TY, Minnaard AJ, Altman JD, Lenz S, Prandi J, Kubler-Kielb J, Moody DB, Rossjohn J, Van Rhijn I (2019) A T-cell receptor escape channel allows broad T-cell response to CD1b and membrane phospholipids. Nat Commun 10: 56
34Srikhanta YN, Hutton ML, Awad MM, Drinkwater N, Singleton J, Day SL, Cunningham BA, McGowan S, Lyras D (2019) Cephamycins inhibit pathogen sporulation and effectively treat recurrent Clostridioides difficile infection. Nat Microbiol
35Taylor RA, Fraser M, Rebello RJ, Boutros PC, Murphy DG, Bristow RG, Risbridger GP (2019) The influence of BRCA2 mutation on localized prostate cancer. Nat Rev Urol
36Toivanen R, Furic L (2019) A balancing act: PHLPP2 fine tunes AKT activity and MYC stability in prostate cancer. J Cell Biol 218: 1771-1772
37 Torpe N, Gopal S, Baltaci O, Rella L, Handley A, Korswagen HC, Pocock R (2019) A Protein Disulfide Isomerase Controls Neuronal Migration through Regulation of Wnt Secretion. Cell Rep 26: 3183-3190.e5
38Traven A, Naderer T (2019) Central metabolic interactions of immune cells and microbes: prospects for defeating infections. EMBO Rep 20: e47995
39Watt MJ, Clark AK, Selth LA, Haynes VR, Lister N, Rebello R, Porter LH, Niranjan B, Whitby ST, Lo J, Huang C, Schittenhelm RB, Anderson KE, Furic L, Wijayaratne PR, Matzaris M, Montgomery MK, Papargiris M, Norden S, Febbraio M, Risbridger GP, Frydenberg M, Nomura DK, Taylor RA (2019) Suppressing fatty acid uptake has therapeutic effects in preclinical models of prostate cancer. Sci Transl Med 11
40Wirasinha RC, Chan A, Yap JY, Hu DY, Teh CE, Gray DHD, Goodnow CC, Daley SR (2019) Deletion of self-reactive CCR7- thymocytes in the absence of MHC expression on thymic epithelial cells. Cell Death Differ DOI:10.1038/s41418-019-0331-8
41Wu T, Guan J, Handel A, Tscharke DC, Sidney J, Sette A, Wakim LM, Sng XYX, Thomas PG, Croft NP, Purcell AW, La Gruta NL (2019) Quantification of epitope abundance reveals the effect of direct and cross-presentation on influenza CTL responses. Nat Commun 10: 2846
42Zhang Q, McKenzie NJ, Warneford-Thomson R, Gail EH, Flanigan SF, Owen BM, Lauman R, Levina V, Garcia BA, Schittenhelm RB, Bonasio R, Davidovich C (2019) RNA exploits an exposed regulatory site to inhibit the enzymatic activity of PRC2. Nat Struct Mol Biol 26: 237-247
1 An Y, Wang J, Li C, Leier A, Marquez-Lago T, Wilksch J, Zhang Y, Webb GI, Song J, Lithgow T (2018) Comprehensive assessment and performance improvement of effector protein predictors for bacterial secretion systems III, IV and VI. Brief Bioinform 19: 148-161
2Balaji GR, Aguilar OA, Tanaka M, Shingu-Vazquez MA, Fu Z, Gully BS, Lanier LL, Carlyle JR, Rossjohn J, Berry R (2018) Recognition of host Clr-b by the inhibitory NKR-P1B receptor provides a basis for missing-self recognition. Nat Commun 9: 4623
3 Burrows K, Antignano F, Chenery A, Bramhall M, Korinek V, Underhill TM, Zaph C (2018) HIC1 links retinoic acid signalling to group 3 innate lymphoid cell-dependent regulation of intestinal immunity and homeostasis. PLoS Pathog 14: e1006869
4Chan KF, Gully BS, Gras S, Beringer DX, Kjer-Nielsen L, Cebon J, McCluskey J, Chen W, Rossjohn J (2018) Divergent T-cell receptor recognition modes of a HLA-I restricted extended tumour-associated peptide. Nat Commun 9: 1026
5 Chen Z, Zhao P, Li F, Leier A, Marquez-Lago TT, Wang Y, Webb GI, Smith AI, Daly RJ, Chou KC, Song J (2018) iFeature: a python package and web server for features extraction and selection from protein and peptide sequences. Bioinformatics
6 Chennamadhavuni D, Saavedra-Avila NA, Carreno LJ, Guberman-Pfeffer MJ, Arora P, Yongqing T, Pryce R, Koay HF, Godfrey DI, Keshipeddy S, Richardson SK, Sundararaj S, Lo JH, Wen X, Gascon JA, Yuan W, Rossjohn J, Le Nours J, Porcelli SA, Howell AR (2018) Dual Modifications of alpha-Galactosylceramide Synergize to Promote Activation of Human Invariant Natural Killer T Cells and Stimulate Anti-tumor Immunity. Cell Chem Biol 25: 571-584.e8
7 Christofferson AJ, Al-Garawi ZS, Todorova N, Turner J, Del Borgo MP, Serpell LC, Aguilar M-I, Yarovsky I (2018) Identifying the Coiled-Coil Triple Helix Structure of β-Peptide Nanofibers at Atomic Resolution. ACS Nano 12: 9101-9109
8Colafella KMM, Denton KM (2018) Sex-specific differences in hypertension and associated cardiovascular disease. Nat Rev Nephrol 14: 185-201
9Davis GM, Tu S, Anderson JW, Colson RN, Gunzburg MJ, Francisco MA, Ray D, Shrubsole SP, Sobotka JA, Seroussi U, Lao RX, Maity T, Wu MZ, McJunkin K, Morris QD, Hughes TR, Wilce JA, Claycomb JM, Weng Z, Boag PR (2018) The TRIM-NHL protein NHL-2 is a co-factor in the nuclear and somatic RNAi pathways in C. elegans. Elife 7
10Deo P, Chow SH, Hay ID, Kleifeld O, Costin A, Elgass KD, Jiang JH, Ramm G, Gabriel K, Dougan G, Lithgow T, Heinz E, Naderer T (2018) Outer membrane vesicles from Neisseria gonorrhoeae target PorB to mitochondria and induce apoptosis. PLoS Pathog 14: e1006945
11Dodd GT, Michael NJ, Lee-Young RS, Mangiafico SP, Pryor JT, Munder AC, Simonds SE, Bruning JC, Zhang ZY, Cowley MA, Andrikopoulos S, Horvath TL, Spanswick D, Tiganis T (2018) Insulin regulates POMC neuronal plasticity to control glucose metabolism. Elife 7
12Evans RG, Ow CPC (2018) Heterogeneity of renal cortical oxygenation: seeing is believing. Kidney Int 93: 1278-1280
13Faridi P, Li C, Ramarathinam SH, Vivian JP, Illing PT, Mifsud NA, Ayala R, Song J, Gearing LJ, Hertzog PJ, Ternette N, Rossjohn J, Croft NP, Purcell AW (2018) A subset of HLA-I peptides are not genomically templated: Evidence for cis- and trans-spliced peptide ligands. Sci Immunol 3
14 Forrester JV, McMenamin PG, Dando SJ (2018) CNS infection and immune privilege. Nat Rev Neurosci 19: 655-671
15 Galperin M, Farenc C, Mukhopadhyay M, Jayasinghe D, Decroos A, Benati D, Tan LL, Ciacchi L, Reid HH, Rossjohn J, Chakrabarti LA, Gras S (2018) CD4(+) T cell-mediated HLA class II cross-restriction in HIV controllers. Sci Immunol 3
16Garriga D, Headey S, Accurso C, Gunzburg M, Scanlon M, Coulibaly F (2018) Structural basis for the inhibition of poxvirus assembly by the antibiotic rifampicin. Proc Natl Acad Sci U S A 115: 8424-8429
17 Godfrey DI, Le Nours J, Andrews DM, Uldrich AP, Rossjohn J (2018) Unconventional T Cell Targets for Cancer Immunotherapy. Immunity 48: 453-473
18Grant EJ, Josephs TM, Loh L, Clemens EB, Sant S, Bharadwaj M, Chen W, Rossjohn J, Gras S, Kedzierska K (2018) Broad CD8(+) T cell cross-recognition of distinct influenza A strains in humans. Nat Commun 9: 5427
19Greule A, Stok JE, De Voss JJ, Cryle MJ (2018) Unrivalled diversity: the many roles and reactions of bacterial cytochromes P450 in secondary metabolism. Nat Prod Rep
20Grinter R, Hay ID, Song J, Wang J, Teng D, Dhanesakaran V, Wilksch JJ, Davies MR, Littler D, Beckham SA, Henderson IR, Strugnell RA, Dougan G, Lithgow T (2018) FusC, a member of the M16 protease family acquired by bacteria for iron piracy against plants. PLoS Biol 16: e2006026
21Grohmann M, Wiede F, Dodd GT, Gurzov EN, Ooi GJ, Butt T, Rasmiena AA, Kaur S, Gulati T, Goh PK, Treloar AE, Archer S, Brown WA, Muller M, Watt MJ, Ohara O, McLean CA, Tiganis T (2018) Obesity Drives STAT-1-Dependent NASH and STAT-3-Dependent HCC. Cell 175: 1289-1306.e20
22Gunasinghe SD, Shiota T, Stubenrauch CJ, Schulze KE, Webb CT, Fulcher AJ, Dunstan RA, Hay ID, Naderer T, Whelan DR, Bell TDM, Elgass KD, Strugnell RA, Lithgow T (2018) The WD40 Protein BamB Mediates Coupling of BAM Complexes into Assembly Precincts in the Bacterial Outer Membrane. Cell Rep 23: 2782-2794
23 Hankir MK, Seyfried F, Miras AD, Cowley MA (2018) Brain Feeding Circuits after Roux-en-Y Gastric Bypass. Trends Endocrinol Metab
24Illing PT, Pymm P, Croft NP, Hilton HG, Jojic V, Han AS, Mendoza JL, Mifsud NA, Dudek NL, McCluskey J, Parham P, Rossjohn J, Vivian JP, Purcell AW (2018) HLA-B57 micropolymorphism defines the sequence and conformational breadth of the immunopeptidome. Nat Commun 9: 4693
25 Kamerkar SC, Kraus F, Sharpe AJ, Pucadyil TJ, Ryan MT (2018) Dynamin-related protein 1 has membrane constricting and severing abilities sufficient for mitochondrial and peroxisomal fission. Nat Commun 9: 5239
26Knoblich K, Cruz Migoni S, Siew SM, Jinks E, Kaul B, Jeffery HC, Baker AT, Suliman M, Vrzalikova K, Mehenna H, Murray PG, Barone F, Oo YH, Newsome PN, Hirschfield G, Kelly D, Lee SP, Parekkadan B, Turley SJ, Fletcher AL (2018) The human lymph node microenvironment unilaterally regulates T-cell activation and differentiation. PLoS Biol 16: e2005046
27Koch B, Barugahare AA, Lo TL, Huang C, Schittenhelm RB, Powell DR, Beilharz TH, Traven A (2018) A Metabolic Checkpoint for the Yeast-to-Hyphae Developmental Switch Regulated by Endogenous Nitric Oxide Signaling. Cell Rep 25: 2244-2258.e7
28La Gruta NL, Gras S, Daley SR, Thomas PG, Rossjohn J (2018) Understanding the drivers of MHC restriction of T cell receptors. Nat Rev Immunol 18: 467-478
29La HM, Makela JA, Chan AL, Rossello FJ, Nefzger CM, Legrand JMD, De Seram M, Polo JM, Hobbs RM (2018) Identification of dynamic undifferentiated cell states within the male germline. Nat Commun 9: 2819
30Lam M, Royce SG, Samuel CS, Bourke JE (2018) Serelaxin as a novel therapeutic opposing fibrosis and contraction in lung diseases. Pharmacol Ther 187: 61-70
31Lawrence MG, Obinata D, Sandhu S, Selth LA, Wong SQ, Porter LH, Lister N, Pook D, Pezaro CJ, Goode DL, Rebello RJ, Clark AK, Papargiris M, Van Gramberg J, Hanson AR, Banks P, Wang H, Niranjan B, Keerthikumar S, Hedwards S, Huglo A, Yang R, Henzler C, Li Y, Lopez-Campos F, Castro E, Toivanen R, Azad A, Bolton D, Goad J, Grummet J, Harewood L, Kourambas J, Lawrentschuk N, Moon D, Murphy DG, Sengupta S, Snow R, Thorne H, Mitchell C, Pedersen J, Clouston D, Norden S, Ryan A, Dehm SM, Tilley WD, Pearson RB, Hannan RD, Frydenberg M, Furic L, Taylor RA, Risbridger GP (2018) Patient-derived Models of Abiraterone- and Enzalutamide-resistant Prostate Cancer Reveal Sensitivity to Ribosome-directed Therapy. Eur Urol
32Lee T-H, Hirst DJ, Kulkarni K, Del Borgo MP, Aguilar M-I (2018) Exploring Molecular-Biomembrane Interactions with Surface Plasmon Resonance and Dual Polarization Interferometry Technology: Expanding the Spotlight onto Biomembrane Structure. Chemical Reviews 118: 5392-5487
33Li F, Li C, Marquez-Lago TT, Leier A, Akutsu T, Purcell AW, Smith AI, Lithgow T, Daly RJ, Song J, Chou KC (2018) Quokka: a comprehensive tool for rapid and accurate prediction of kinase family-specific phosphorylation sites in the human proteome. Bioinformatics
34Low LY, Harrison PF, Gould J, Powell DR, Choo JM, Forster SC, Chapman R, Gearing LJ, Cheung JK, Hertzog P, Rood JI (2018) Concurrent Host-Pathogen Transcriptional Responses in a Clostridium perfringens Murine Myonecrosis Infection. MBio 9
35Manning SA, Dent LG, Kondo S, Zhao ZW, Plachta N, Harvey KF (2018) Dynamic Fluctuations in Subcellular Localization of the Hippo Pathway Effector Yorkie In Vivo. Curr Biol 28: 1651-1660.e4
36McArthur K, Chappaz S, Kile BT (2018) Apoptosis in megakaryocytes and platelets: the life and death of a lineage. Blood 131: 605-610
37McArthur K, Kile BT (2018) Apoptotic Caspases: Multiple or Mistaken Identities? Trends Cell Biol 28: 475-493
38McArthur K, Whitehead LW, Heddleston JM, Li L, Padman BS, Oorschot V, Geoghegan ND, Chappaz S, Davidson S, San Chin H, Lane RM, Dramicanin M, Saunders TL, Sugiana C, Lessene R, Osellame LD, Chew TL, Dewson G, Lazarou M, Ramm G, Lessene G, Ryan MT, Rogers KL, van Delft MF, Kile BT (2018) BAK/BAX macropores facilitate mitochondrial herniation and mtDNA efflux during apoptosis. Science 359
39Montgomery MK, Mokhtar R, Bayliss J, Parkington HC, Suturin VM, Bruce CR, Watt MJ (2018) Perilipin 5 Deletion Unmasks an Endoplasmic Reticulum Stress - Fibroblast Growth Factor 21 Axis in Skeletal Muscle. Diabetes
40 Pidsley R, Lawrence MG, Zotenko E, Niranjan B, Statham A, Song J, Chabanon RM, Qu W, Wang H, Richards M, Nair SS, Armstrong NJ, Nim HT, Papargiris M, Balanathan P, French H, Peters T, Norden S, Ryan A, Pedersen J, Kench J, Daly RJ, Horvath LG, Stricker P, Frydenberg M, Taylor RA, Stirzaker C, Risbridger GP, Clark SJ (2018) Enduring epigenetic landmarks define the cancer microenvironment. Genome Res 28: 625-638
41 Poon CLC, Liu W, Song Y, Gomez M, Kulaberoglu Y, Zhang X, Xu W, Veraksa A, Hergovich A, Ghabrial A, Harvey KF (2018) A Hippo-like Signaling Pathway Controls Tracheal Morphogenesis in Drosophila melanogaster. Dev Cell 47: 564-575.e5
42Quinn KM, Fox A, Harland KL, Russ BE, Li J, Nguyen THO, Loh L, Olshanksy M, Naeem H, Tsyganov K, Wiede F, Webster R, Blyth C, Sng XYX, Tiganis T, Powell D, Doherty PC, Turner SJ, Kedzierska K, La Gruta NL (2018) Age-Related Decline in Primary CD8(+) T Cell Responses Is Associated with the Development of Senescence in Virtual Memory CD8(+) T Cells. Cell Rep 23: 3512-3524
43Rabi R, Larcombe S, Mathias R, McGowan S, Awad M, Lyras D (2018) Clostridium sordellii outer spore proteins maintain spore structural integrity and promote bacterial clearance from the gastrointestinal tract. PLoS Pathog 14: e1007004
44Ratnadiwakara M, Archer SK, Dent CI, Ruiz De Los Mozos I, Beilharz TH, Knaupp AS, Nefzger CM, Polo JM, Anko ML (2018) SRSF3 promotes pluripotency through Nanog mRNA export and coordination of the pluripotency gene expression program. Elife 7
45Rawlinson SM, Zhao T, Rozario AM, Rootes CL, McMillan PJ, Purcell AW, Woon A, Marsh GA, Lieu KG, Wang LF, Netter HJ, Bell TDM, Stewart CR, Moseley GW (2018) Viral regulation of host cell biology by hijacking of the nucleolar DNA-damage response. Nat Commun 9: 3057
46Reichenbach A, Stark R, Mequinion M, Denis RRG, Goularte JF, Clarke RE, Lockie SH, Lemus MB, Kowalski GM, Bruce CR, Huang C, Schittenhelm RB, Mynatt RL, Oldfield BJ, Watt MJ, Luquet S, Andrews ZB (2018) AgRP Neurons Require Carnitine Acetyltransferase to Regulate Metabolic Flexibility and Peripheral Nutrient Partitioning. Cell Rep 22: 1745-1759
47Shin SY, Muller AK, Verma N, Lev S, Nguyen LK (2018) Systems modelling of the EGFR-PYK2-c-Met interaction network predicts and prioritizes synergistic drug combinations for triple-negative breast cancer. PLoS Comput Biol 14: e1006192
48Short KM, Combes A, Lisnyak V, Lefevre J, Jones L, Little MH, Hamilton N, Smyth IM (2018) Branching morphogenesis in the developing kidney is not impacted by nephron formation or integration. Elife 7
49Song J, Li F, Leier A, Marquez-Lago TT, Akutsu T, Haffari G, Chou KC, Webb GI, Pike RN, Hancock J (2018) PROSPERous: high-throughput prediction of substrate cleavage sites for 90 proteases with improved accuracy. Bioinformatics 34: 684-687
50Spicer BA, Law RHP, Caradoc-Davies TT, Ekkel SM, Bayly-Jones C, Pang SS, Conroy PJ, Ramm G, Radjainia M, Venugopal H, Whisstock JC, Dunstone MA (2018) The first transmembrane region of complement component-9 acts as a brake on its self-assembly. Nat Commun 9: 3266
51Sundararaj S, Zhang J, Krovi SH, Bedel R, Tuttle KD, Veerapen N, Besra GS, Khandokar Y, Praveena T, Le Nours J, Matsuda JL, Rossjohn J, Gapin L (2018) Differing roles of CD1d2 and CD1d1 proteins in type I natural killer T cell development and function. Proc Natl Acad Sci U S A 115: E1204-e1213
52Traore DAK, Wisniewski JA, Flanigan SF, Conroy PJ, Panjikar S, Mok YF, Lao C, Griffin MDW, Adams V, Rood JI, Whisstock JC (2018) Crystal structure of TcpK in complex with oriT DNA of the antibiotic resistance plasmid pCW3. Nat Commun 9: 3732
53Tucey TM, Verma J, Harrison PF, Snelgrove SL, Lo TL, Scherer AK, Barugahare AA, Powell DR, Wheeler RT, Hickey MJ, Beilharz TH, Naderer T, Traven A (2018) Glucose Homeostasis Is Important for Immune Cell Viability during Candida Challenge and Host Survival of Systemic Fungal Infection. Cell Metab 27: 988-1006 e7
54Udugama M, Sanij E, Voon HPJ, Son J, Hii L, Henson JD, Chan FL, Chang FTM, Liu Y, Pearson RB, Kalitsis P, Mann JR, Collas P, Hannan RD, Wong LH (2018) Ribosomal DNA copy loss and repeat instability in ATRX-mutated cancers. Proc Natl Acad Sci U S A 115: 4737-4742
55Vidor CJ, Watts TD, Adams V, Bulach D, Couchman E, Rood JI, Fairweather NF, Awad M, Lyras D (2018) Clostridium sordellii Pathogenicity Locus Plasmid pCS1-1 Encodes a Novel Clostridial Conjugation Locus. MBio 9
56Voon HPJ, Udugama M, Lin W, Hii L, Law RHP, Steer DL, Das PP, Mann JR, Wong LH (2018) Inhibition of a K9/K36 demethylase by an H3.3 point mutation found in paediatric glioblastoma. Nat Commun 9: 3142
57 Walker RG, McCoy JC, Czepnik M, Mills MJ, Hagg A, Walton KL, Cotton TR, Hyvönen M, Lee RT, Gregorevic P, Harrison CA, Thompson TB (2018) Molecular characterization of latent GDF8 reveals mechanisms of activation. Proceedings of the National Academy of Sciences 115: E866
58Wang J, Li J, Yang B, Xie R, Marquez-Lago TT, Leier A, Hayashida M, Akutsu T, Zhang Y, Chou KC, Selkrig J, Zhou T, Song J, Lithgow T (2018) Bastion3: a two-layer ensemble predictor of type III secreted effectors. Bioinformatics
59Wang J, Yang B, Leier A, Marquez-Lago TT, Hayashida M, Rocker A, Yanju Z, Akutsu T, Chou KC, Strugnell RA, Song J, Lithgow T (2018) Bastion6: a bioinformatics approach for accurate prediction of type VI secreted effectors. Bioinformatics
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