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Rood Laboratory

Functional Biology of Bacterial Pathogens

Welcome to the Rood Lab

Research in our laboratory is centred on the molecular genetics of pathogenic anaerobic bacteria, asking three fundamental mechanistic questions.

  • How do pathogenic anaerobes, particularly Clostridium perfringens, cause disease in humans and animals?
  • How is the expression of virulence genes regulated in these bacteria?
  • How do virulence and antibiotic resistance genes move from one bacterium to another?

We're part of the Monash Biomedicine Discovery Institute, a member of the Infection & Immunity Program and
the Department of Microbiology.

Professor Julian Rood

My global research connections, partners and funding can be viewed on my Monash Research Profile.

If you are a student interested in doing research in our lab, visit Supervisor Connect.

Click the links below to connect with me on Twitter, ORCID, Google Scholar, LinkedIn and Facebook.

Our research

Our work involves bacterial genetics, molecular biology, genomics and transcriptomics, gene cloning, PCR technology, protein purification and other essentially molecular methods. We have an ongoing collaboration with Professor James Whisstock’s structural biology group.

  • The biology of large clostridial plasmids

    Understanding bacterial virulence and antibiotic resistance mechanisms and how these genes are transferred is important for fighting infectious disease.

  • Regulatory networks in the pathogenic clostridia

    We focus on the characterisation of two signal transduction systems (VirS/VirR and RevS/RevR), which regulate the production of several toxin and virulence genes that are involved in the pathogenesis of Clostridium perfringens -mediated gas gangrene.

  • The pathogenesis of clostridial infections

    Our studies involve the analysis of novel virulence factors involved in C. perfringens-mediated clostridial myonecrosis or gas gangrene.

Lab members

We are committed to excellence in research.

Publications

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News

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Join Our Lab

We're always interested in collaborating with bright and motivated researchers, clinicians and industry. Whether you want to research, study or partner with us to accelerate our discoveries, find out about the work we do.

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