Polymer grafted inorganic nanoparticles towards in vivo molecule imaging applications
Owing to the excellent imaging performance and versatility of multimodal, stimuli-responsive, and targeted imaging, inorganic nanoparticle-based nanoparticles have been extensively investigated as a potential alternative to conventional molecular imaging probes. 1-2 The current talk will mainly focus on the development of advanced molecular imaging probes based on the polymer grafted inorganic nanoparticles.3-5 In vivo imaging applications in MRI, optical, and dual-modality imaging using nanoprobes which can act as a diagnostic and prognostic marker for a variety of morbidities (e.g. tumour, cardiovascular disease) will be intensively discussed.3, 6-7
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- Qiao, R.; Zeng, J. F.; Jia, Q. J.; Du, J.; Shen, L.; Gao, M. Y., Magnetic Iron Oxide Nanoparticle—an Important Cornerstone of MR Molecular Imaging of Tumors, Acta Physico - Chimica Sinica 2012, 28 (5), 993-1011.
- Hou, Y.; Qiao, R.; Fang, F.; Wang, X.; Dong, C.; Liu, K; Liu, C; Liu, Z.; Lei, H.; Wang, F.; Gao, M., NaGdF4 nanoparticle-based molecular probes for magnetic resonance imaging of intraperitoneal tumor xenografts in vivo, ACS Nano 7(1) (2013) 330-338.
- Tang, S. Y.; Qiao, R.; Yan, S.; Yuan, D.; Zhao, Q. B.; Yun, G. L.; Davis, T. P.; Li, W. H., Microfluidic Mass Production of Stabilized and Stealthy Liquid Metal Nanoparticles. Small 2018, 14 (21), 1800118.
- Qiao, R.; Esser, L.; Fu, C.; Zhang, C.; Hu, J.; Ramírez-arcía, P.; Li, Y.; Quinn, J. F.; Whittaker, M. R.; Whittaker, A. K.; Davis, T. P., Bioconjugation and Fluorescence Labeling of Iron Oxide Nanoparticles Grafted with Bromomaleimide-Terminal Polymers. Biomacromolecules 2018, 19, 4423-4429.
- Qiao, R.; Liu, C .; Liu, M.; Hu, H.; Liu, C.; Hou, Y.; Wu, K.; Lin, Y.; Liang, J.; Gao, M., Ultrasensitive in Vivo Detection of Primary Gastric Tumor and Lymphatic Metastasis Using Upconversion Nanoparticles, ACS Nano, 9 (2), 2120-2129.
- Qiao, R.; Qiao, H.; Zhang Y.; Chi C.; Tian J.; Zhang L.; Cao F.; Gao M.; Molecular Imaging of Vulnerable Atherosclerotic Plaques in Vivo with Osteopontin-Specific Upconversion Nanoprobes, ACS Nano, 2017, 11 (2), 1816-1825.
Dr. Qiao received her Bachelor and Master’s degree in Pharmaceutical Science from Peking University and obtained her PhD degree in Physical Chemistry from Chinese Academy of Science in 2014. She worked as a research assistant (2007-2009) and Associate Research Fellow (2009-2016) at the Institute of Chemistry, Chinese Academy of Sciences (ICCAS) in Prof Mingyuan Gao’s group. In 2016, she was promoted to be an associate Professor and project leader at the CAS Key laboratory of colloidal, interface and chemical thermodynamics in ICCAS. In 2017, she joined Prof Thomas Davis’ group in Monash Institute of Pharmaceutical Sciences (MIPS) as a research fellow and co-leader of signature project in ARC Centre of Excellence in Convergent Bio-Nano Science & Technology (CBNS). She has authored/co-authored over 50 peer-reviewed papers and 2 book chapters with >2800 citations. Her current research is focusing on multifuncti onal inorganic/organic nanohybrids for molecular imaging and drug delivery applications.