A/Professor Thomas Naderer

EXPERTISE

  • Host-Pathogen Interactions
  • Molecular microbiology
  • Alternative approaches to control infections
  • Repurposing drugs that inhibit host factors

Thomas and his team specialise in imaging the dynamic host-pathogen interactions using live-cell, super resolution and electron microscopes. They use biochemical and molecular approaches to identify how microbial pathogens hijack host pathways during infections. By employing CRISPR whole-genome screens in macrophages, they identify how the immune system controls infections with the aim to develop host-targeted approaches in infectious diseases. The Naderer lab also uses animal models of infection and human stem cell-based approaches to study lung and sexually transmitted infections.

Dr Naderer leads the host-pathogen interaction laboratory at the Biomedicine Discovery Institute at Monash University since 2012. After completing his undergraduate studies at the University Vienna, Austria, and a Masters at the University of Nottingham, UK, Thomas Naderer obtained his PhD from the University of Melbourne, Australia in 2004. His work is supported from national funds, including a ARC Future Fellowship, NHMRC Project and Ideas Grants. He worked previously at the Bio21, University of Melbourne, before joining the NHMRC Pro

AMR FOCUS

  • Imaging dynamic host-pathogen interactions.
  • Bacterial membrane vesicles as delivery and vaccine candidates.
  • AMR due to outer membrane vesicle formation.
  • Metabolic interactions between host cells and pathogens.
  • Microbial toxins and their activity in host cells.
  • Immune responses to microbial infections.

IMPACT

  • Host-directed antimicrobials.
  • Understanding fundamental host-pathogen interactions.
  • Alternative approaches to control infections by developing host-directed therapies.
  • Repurposing of drugs that inhibit host factors and prevent infections.

CENTRE LEADERSHIP

  • Head - Preclinical Testing Facility
  • Chair - Community engagement strategy 2020