Malignant Haematology & Stem Cell Transplantation Service

Stem Cell Transplantation Research Group


For the first time in 2008 a specific programme systematically evaluating critical short and long-term sequelae of SCT was initiated within the Malignant Haematology & Stem Cell Transplantation Service.

Late Effects Clinic. A specific clinic evaluatinglong-term survivors ofSCT commenced in 2008. As well as providing critical patient medical follow-up the clinic provides a focus for studies relating to the long-term impact of SCT on organ function, quality of life and the sequential banking of peripheral blood cells for clonality studies as a predictor of secondary malignancy.

Immune reconstitution following novel reduced intensity conditioned (RIC) SCT. This is a longitudinal study of immune recovery following 2 novel RIC SCT strategies correlating quantitative and functional analyses of immune cells with SCT complications and recovery.

Longitudinal audit of invasive fungal infections (IFI) in SCT and acute leukaemia induction. IFI is one of the most ominous events complicating SCT and leukaemic induction therapy. This studyis a prospective analysis of IFI incidence and anti-fungal drug usage including intermittent comparison with historical data preceding the introduction in early 2008 of modified strategies for the prevention of IFI.