2017 Publications

Julian Smith
L-R: Prof Karin Jandeleit-Dahm, Dr Stephen Gray and ;Dr Jay Jha are researching inhibition of enzymes known to cause kidney injury in diabetes. See Diabetologia paper. Image: Life Scientist

2017 publications

Feature article:

Reversing damage caused by diabetes complications: Professor Karin Jandeleit-Dahm, Dr Stephen Gray and Dr Jay Jha are researching inhibition of enzymes known to cause kidney injury in diabetes.


Gray SP, Jha JC, Kennedy K, van Bommel E, Chew P, Szyndralewiez C, Touyz RM, Schmidt HH, Cooper ME, Jandeleit-Dahm KA. Combined NOX1/4 inhibition with GKT137831 in mice provides dose-dependent reno- and atheroprotection even in established micro- and macrovascular disease. Diabetologia. 2017 Feb 3. doi: 10.1007/s00125-017-4215-5. [Epub ahead of print]


Kellow, NJ, Sourris, KC, Reid, CM & Coughlan, MT 2017, 'Effect of dietary prebiotic supplementation on metabolic biomarkers in adults with prediabetes - a crossover RCT' Nutrition Society of Australia Annual Scientific Meeting, Melbourne, Australia, 29/11/16 - 2/12/16, pp. 70-71. DOI: 10.1016/j.jnim.2017.04.036

Book Chapter

Gray, SP, Di Marco, E, Candido, R, Cooper, ME & Jandeleit-Dahm, KAM 2017, Pathogenesis of Macrovascular Complications in Diabetes. in RIG Holt, CS Cockram, A Flyvbjerg & BJ Goldstein (eds), Textbook of Diabetes. Wiley-Blackwell, pp. 611-628. DOI: 10.1002/9781118924853.ch41

Comment / Debate

McFadyen, JD & Cooper, ME 2017, 'Diabetic kidney disease: as easy as aPC?' Blood, vol 130, no. 12, pp. 1390-1391. DOI: 10.1182/blood-2017-08-798314


Jha, JC, Watson, AMD, Mathew, G, de Vos, LC & Jandeleit-Dahm, K 2017, 'The emerging role of NADPH oxidase NOX5 in vascular disease' Clinical Science, vol 131, no. 10, pp. 981-990. DOI: 10.1042/CS20160846
Ying, YL, Chen, YC, Jandeleit-Dahm, K & Peter, K 2017, 'GLP-1 receptor agonists: An example of the challenge for animal models to predict plaque instability/rupture and cardiovascular outcomes' Atherosclerosis, vol 265, pp. 250-252. DOI: 10.1016/j.atherosclerosis.2017.08.006

Review Article

Rafehi, H, Karagiannis, TC & El-Osta, A 2017, 'Pharmacological histone deacetylation distinguishes transcriptional regulators' Current Topics in Medicinal Chemistry, vol 17, no. 14, pp. 1611 - 1622. DOI: 10.2174/1568026617666161104104341

Journal Articles

Alrashdi SF, Deliyanti D, Talia DM, Wilkinson-Berka JL. Endothelin-2 Injures the Blood-Retinal Barrier and Macroglial Müller Cells: Interactions with Angiotensin II, Aldosterone, and NADPH Oxidase.Am J Pathol. 2017 Dec 15. pii: S0002-9440(17)30739-3. doi: 10.1016/j.ajpath.2017.11.009. [Epub ahead of print]

Borg DJ, Yap FYT, Keshvari S, Simmons DG, Gallo LA, Fotheringham AK, Zhuang A, Slattery RM, Hasnain SZ, Coughlan MT, Kantharidis P, Forbes JM. Perinatal exposure to high dietary advanced glycation end products in transgenic NOD8.3 mice leads to pancreatic beta cell dysfunction. Islets. 2017 Nov 20:0. doi: 10.1080/19382014.2017.1405189. [Epub ahead of print]

Braun LA, Ou R, Kure C, Trang A, Rosenfeldt F. Prevalence ofZinc Deficiency in Cardiac Surgery Patients. Heart Lung Circ. 2017 Aug 14. pii:S1443-9506(17)31342-2. doi: 10.1016/j.hlc.2017.07.009. [Epub ahead of print]

Brennan E et al. Tikellis C, Jandeleit-Dahm KAM, Kantharidis P. Protective Effect of let-7 miRNA Family in Regulating Inflammation in Diabetes-Associated Atherosclerosis. Diabetes. 2017 Aug;66(8):2266-2277. doi: 10.2337/db16-1405. Epub 2017 May 9.

Carrington MJ, Zimmet P. Nurse health and lifestyle modification versus standard care in 40 to 70 year old regional adults: study protocol of the Management to Optimise Diabetes and mEtabolic syndrome Risk reduction via Nurse-led intervention (MODERN) randomized controlled trial. BMC Health Serv Res. 2017 Dec 6;17(1):813. doi: 10.1186/s12913-017-2769-z.

Costantino S, Libby P, Kishore R, Tardif JC, El-Osta A, Paneni F. Epigenetics and precision medicine in cardiovascular patients: from basic concepts to the clinical arena. Eur Heart J. 2017 Oct 23. doi: 10.1093/eurheartj/ehx568. [Epub ahead of print]

Deliyanti D, Talia DM, Zhu T, Maxwell MJ, Agrotis A, Jerome JR, Hargreaves EM, Gerondakis S, Hibbs ML, Mackay F, Wilkinson-Berka JL. Foxp3+ Tregs are recruited to the retina to repair pathological angiogenesis. Nat Commun. 2017 Sep 29;8(1):748. doi: 10.1038/s41467-017-00751-w.

Han ML et al. Cooper MA. Investigating the Interaction of Octapeptin A3 with Model Bacterial Membranes. ACS Infect Dis. 2017 Jul 11. doi: 10.1021/acsinfecdis.7b00065. [Epub ahead of print]

Jha JC, Banal C, Okabe J, Gray SP, Hettige T, Chow BSM, Thallas-Bonke V, De Vos L, Holterman CE, Coughlan MT, Power DA, Skene A, Ekinci EI, Cooper ME, Touyz RM, Kennedy CR, Jandeleit-Dahm K. NADPH Oxidase-Nox5 accelerates renal injury in diabetic nephropathy. Diabetes. 2017 Jul 26. pii: db161585. doi: 10.2337/db16-1585. [Epub ahead of print]

Jha JC, Watson AM, Mathew G, de Vos LC, Jandeleit-Dahm K. The emerging role of NADPH oxidase NOX5 in vascular disease. Clin Sci (Lond). 2017 May 1;131(10):981-990. doi: 10.1042/CS20160846.

Keating ST, van Diepen JA, Riksen N, El-Osta A. Epigenetics in diabetic nephropathy, immunity and metabolism. Diabetologia. 2017 Nov 11. doi: 10.1007/s00125-017-4490-1. [Epub ahead of print]

Kirkham R e al. Zimmet P; Northern Territory Diabetes in Pregnancy Partnership. Implementation of a diabetes in pregnancy clinical register in a complex setting: Findings from a process evaluation. PLoS One. 2017 Aug 4;12(8):e0179487. doi: 10.1371/journal.pone.0179487. eCollection 2017.

Kraakman MJ. Lee MK, Al-Sharea A, Dragoljevic D, Barrett TJ, Montenont E, Basu D, Heywood S, Kammoun HL, Flynn M, Whillas A, Hanssen NM, Febbraio MA, Westein E, Fisher EA, Chin-Dusting J, Cooper ME, Berger JS, Goldberg IJ, Nagareddy PR, Murphy AJ. Neutrophil-derived S100 calcium-binding proteins A8/A9 promote reticulated thrombocytosis and atherogenesis in diabetes. J Clin Invest. 2017 Jun 1;127(6):2133-2147. doi: 10.1172/JCI92450. Epub 2017 May 15

Lin S, Naseri T, Linhart C, Morrell S, Taylor R, McGarvey ST, Zimmet P. Response to comments by Hoyer and Brinks (2017) on: 'Diabetes incidence and projections from prevalence surveys in Samoa over 1978-2013'. Int J Public Health. 2017 Oct 30. doi: 10.1007/s00038-017-1042-x. [Epub ahead of print]

Linhart C, Tukana I, Lin S, Taylor R, Morrell S, Vatucawaqa P, Magliano DJ, Zimmet P. Declines and Plateaux in Smoking Prevalence Over Three Decades in Fiji. Nicotine Tob Res. 2017 Nov 1;19(11):1315-1321. doi: 10.1093/ntr/ntw292.

Liso A et al, Bach LA. Human monocyte-derived dendritic cells exposed to hyperthermia show a distinct gene expression profile and selective upregulation of IGFBP6. Oncotarget. 2017 Jun 1;8(37):60826-60840. doi: 10.18632/oncotarget.18338. eCollection 2017 Sep 22.

Mohammedi K et al. Cooper M. Comparative effects of microvascular and macrovascular disease on the risk of major outcomes in patients with type 2 diabetes. Cardiovasc Diabetol. 2017 Jul 27;16(1):95. doi: 10.1186/s12933-017-0574-y.

Moran CS, Biros E, Krishna SM, Wang Y, Tikellis C, Morton SK, Moxon JV, Cooper ME, Norman PE, Burrell LM, Thomas MC, Golledge J. Resveratrol Inhibits Growth of Experimental Abdominal Aortic Aneurysm Associated With Upregulation of Angiotensin-Converting Enzyme 2. Arterioscler Thromb Vasc Biol. 2017 Nov;37(11):2195-2203. doi: 10.1161/ATVBAHA.117.310129. Epub 2017 Sep 21.

Ohkuma T, Jun M, Woodward M, Zoungas S, Cooper ME, Grobbee DE, Hamet P, Mancia G, Williams B, Welsh P, Sattar N, Shaw JE, Rahimi K, Chalmers J; ADVANCE Collaborative Group. Cardiac Stress and Inflammatory Markers as Predictors of Heart Failure in Patients With Type 2 Diabetes: The ADVANCE Trial. Diabetes Care. 2017 Jul 6. pii: dc170509. doi: 10.2337/dc17-0509. [Epub ahead of print]

Perkovic V et al. Cooper M. Management of patients with diabetes and CKD: conclusions from a "Kidney Disease: Improving Global Outcomes" (KDIGO) Controversies Conference. Kidney Int. 2016 Dec;90(6):1175-1183. doi: 10.1016/j.kint.2016.09.010.

Quaife-Ryan GA, Sim CB, Ziemann 2, Kaspi A, Rafehi H, Ramialison M, El-Osta A, Hudson JE, Porrello ER. Multi-Cellular Transcriptional Analysis of Mammalian Heart Regeneration. Circulation. 2017 Jul 21. pii: CIRCULATIONAHA.117.028252. doi: 10.1161/CIRCULATIONAHA.117.028252. [Epub ahead of print]

Rafehi H, Kaspi A, Ziemann M, Okabe J, Karagiannis TC, El-Osta A. Systems approach to the pharmacological actions of HDAC inhibitors reveals EP300 activities and convergent mechanisms of regulation in diabetes. Epigenetics. 2017 Sep 8:0. doi: 10.1080/15592294.2017.1371892. [Epub ahead of print]

Rubino F et al. Zimmet PZ; Delegates of the 2nd Diabetes Surgery Summit.Metabolic Surgery in the Treatment Algorithm for Type 2 Diabetes: a Joint Statement by International Diabetes Organizations. Obes Surg. 2017 Jan;27(1):2-21. doi: 10.1007/s11695-016-2457-9.

Sathish T et al. Zimmet PZ. Baseline characteristics of participants in the Kerala Diabetes Prevention Program: a cluster randomized controlled trial of lifestyle intervention in Asian Indians. Diabet Med. 2017 May;34(5):647-653. doi: 10.1111/dme.13165. Epub 2016 Jul 15.

Snelson M, Clarke RE, Coughlan MT. Stirring the Pot: Can Dietary Modification Alleviate the Burden of CKD? Nutrients. 2017 Mar 11;9(3). pii: E265. doi: 10.3390/nu9030265.

Sulaiman N et al, Zimmet P. Prevalence of overweight and obesity in United Arab Emirates Expatriates: the UAE National Diabetes and Lifestyle Study. Diabetol Metab Syndr. 2017 Nov 2;9:88. doi: 10.1186/s13098-017-0287-0. eCollection 2017.

Tabesh M, Shaw JE, Zimmet PZ, Soderberg S, Kowlessur S, Timol M, Joonas N, Alberti GMM, Tuomilehto J, Shaw BJ, Magliano DJ. Meeting American Diabetes Association diabetes management targets: trends in Mauritius. Diabet Med. 2017 Aug 9. doi: 10.1111/dme.13447. [Epub ahead of print]

Ung L, Pattamatta U, Carnt N, Wilkinson-Berka JL, Liew G, White AJR. Oxidative stress and reactive oxygen species: a review of their role in ocular disease. Clin Sci (Lond). 2017 Dec 4;131(24):2865-2883. doi: 10.1042/CS20171246. Print 2017 Dec 15.

Ying YL, Chen YC, Jandeleit-Dahm K, Peter K. GLP-1 receptor agonists: An example of the challenge for animal models to predict plaque instability/rupture and cardiovascular outcomes. Atherosclerosis. 2017 Aug 18. pii: S0021-9150(17)31228-5. doi: 10.1016/j.atherosclerosis.2017.08.006. [Epub ahead of print]

Zhuang A et al. Yap FY, Sourris KC, Kantharidis P, Coughlan MT. Increased liver AGEs induce hepatic injury mediated through an OST48 pathway. Sci Rep. 2017 Sep 25;7(1):12292. doi: 10.1038/s41598-017-12548-4.

Zimmet PZ. Diabetes and its drivers: the largest epidemic in human history? Clin Diabetes Endocrinol. 2017 Jan 18;3:1. doi: 10.1186/s40842-016-0039-3. eCollection 2017.