Department of Immunology Publications 2018

Comment / Debate

Harris, NL & Loke, P 2018, 'Erratum: Recent Advances in Type-2-Cell-Mediated Immunity: Insights from Helminth Infection ((****) ** (***–***), (S1074761317305162)(10.1016/j.immuni.2017.11.015))' Immunity, vol. 48, no. 2. https://doi.org/10.1016/j.immuni.2018.02.011

Letters

Vincent, FB, Lang, T, Kandane-Rathnayake, RK, Downie-Doyle, S, Morand, EF & Rischmueller, M 2018, 'Serum and Urinary Macrophage Migration Inhibitory Factor (MIF) in Primary Sjögren’s Syndrome' Joint Bone Spine. https://doi.org/10.1016/j.jbspin.2018.07.001

Vincent, FB, Lang, T, Kandane-Rathnayake, RK, Downie-Doyle, S, Morand, EF & Rischmueller, M 2018, 'Serum and Urinary Macrophage Migration Inhibitory Factor (MIF) in Primary Sjögren’s Syndrome' Joint Bone Spine. https://doi.org/10.1016/j.jbspin.2018.07.001

Review Articles

Ahmad, S, Azid, NA, Boer, JC, Lim, J, Chen, X, Plebanski, M & Mohamud, R 2018, 'The key role of TNF-TNFR2 interactions in the modulation of allergic inflammation: A review' Frontiers in Immunology, vol. 9, no. NOV, 2572. https://doi.org/10.3389/fimmu.2018.02572

Bouchery, T & Marsland, BJ 2018, 'Airway brush cells: Not as "tuft" as you might think' Science Immunology, vol. 3, no. 28. https://doi.org/10.1126/sciimmunol.aau8719

Brodie, EJ, Infantino, S, Low, MSY & Tarlinton, DM 2018, 'Lyn, lupus, and (B) lymphocytes, a lesson on the critical balance of kinase signaling in immunity' Frontiers in Immunology, vol. 9, no. MAR, 401. https://doi.org/10.3389/fimmu.2018.00401

Chakraborty, A, Boer, JC, Selomulya, C, Plebanski, M & Royce, SG 2018, 'Insights into endotoxin-mediated lung inflammation and future treatment strategies' Expert Review of Respiratory Medicine, vol. 12, no. 11, pp. 941-955. https://doi.org/10.1080/17476348.2018.1523009

Corrie, SR & Plebanski, M 2018, 'The emerging role of nanomaterials in immunological sensing — a brief review' Molecular Immunology, vol. 98, pp. 28-35. https://doi.org/10.1016/j.molimm.2017.12.017

Godfrey, DI, Le Nours, J, Andrews, DM, Uldrich, AP & Rossjohn, J 2018, 'Unconventional T Cell Targets for Cancer Immunotherapy' Immunity, vol. 48, no. 3, pp. 453-473. https://doi.org/10.1016/j.immuni.2018.03.009

Goodall, KJ, Nguyen, A, Sullivan, LC & Andrews, DM 2018, 'The expanding role of murine class Ib MHC in the development and activation of Natural Killer cells' Molecular Immunology. https://doi.org/10.1016/j.molimm.2018.05.001

McFadyen, JD, Schaff, M & Peter, K 2018, 'Current and future antiplatelet therapies: Emphasis on preserving haemostasis' Nature Reviews Cardiology, vol. 15, no. 3, pp. 181-191. https://doi.org/10.1038/nrcardio.2017.206

Reginald, K, Chan, Y, Plebanski, M & Poh, CL 2018, 'Development of peptide vaccines in dengue' Current Pharmaceutical Design, vol. 24, no. 11, pp. 1157-1173. https://doi.org/10.2174/1381612823666170913163904

Sek, K, Mølck, C, Stewart, GD, Kats, L, Darcy, PK & Beavis, PA 2018, 'Targeting adenosine receptor signaling in cancer immunotherapy' International Journal of Molecular Sciences, vol. 19, no. 12, 3837. https://doi.org/10.3390/ijms19123837

Wyres, KL & Holt, KE 2018, 'Klebsiella pneumoniae as a key trafficker of drug resistance genes from environmental to clinically important bacteria' Current Opinion in Microbiology, vol. 45, pp. 131-139. https://doi.org/10.1016/j.mib.2018.04.004

Journal Articles

Alrashdi, SF, Deliyanti, D & Wilkinson-Berka, JL 2018, 'Intravitreal administration of endothelin type A receptor or endothelin type B receptor antagonists attenuates hypertensive and diabetic retinopathy in rats' Experimental Eye Research, vol. 176, pp. 1-9. https://doi.org/10.1016/j.exer.2018.06.025

Anania, JC, Trist, H, Palmer, C, Tan, PS, Kouskousis, B, Chenoweth, A, Kent, S, Mackay, G, Hoi, A, Koelmeyer, R, Slade, CA, Bryant, VL, Hodgkin, PD, Aui, PM, van Zelm, M, Wines, BD & Hogarth, PM 2018, 'The Rare Anaphylaxis-Associated FcγRIIa3 Exhibits Distinct Characteristics From the Canonical FcγRIIa1' Frontiers in Immunology, vol. 9, 1809. https://doi.org/10.3389/fimmu.2018.01809

Baye, E, Ukropec, J, de Courten, MPJ, Mousa, A, Kurdiova, T, Johnson, J, Wilson, K, Plebanski, M, Aldini, G, Ukropcova, B & de Courten, B 2018, 'Carnosine supplementation improves serum resistin concentrations in overweight or obese otherwise healthy adults: A pilot randomized trial' Nutrients, vol. 10, no. 9, 1258. https://doi.org/10.3390/nu10091258

Brennan, EP, Mohan, M, McClelland, A, De Gaetano, M, Tikellis, C, Marai, M, Crean, D, Dai, A, Beuscart, O, Derouiche, S, Gray, SP, Pickering, R, Tan, SM, Godson-Treacy, M, Sheehan, S, Dowdall, JF, Barry, M, Belton, O, Ali-Shah, ST, Guiry, PJ, Jandeleit-Dahm, K, Cooper, ME, Godson, C & Kantharidis, P 2018, 'Lipoxins protect against inflammation in diabetes-associated atherosclerosis' Diabetes, vol. 67, no. 12, pp. 2657-2667. https://doi.org/10.2337/db17-1317

Chakraborty, A, Boer, J, Selomulya, C & Plebanski, M 2018, 'Amino Acid Functionalized Inorganic Nanoparticles as Cutting-Edge Therapeutic and Diagnostic Agents' Bioconjugate Chemistry, vol. 29, no. 3, 28876902, pp. 657-671. https://doi.org/10.1021/acs.bioconjchem.7b00455

De Silva, H, Ffrench, RA, Korem, M, Orlowski-Oliver, E, Curtis, DJ, Spencer, A, Avery, S, Patil, S & Morrissey, CO 2018, 'Contemporary analysis of functional immune recovery to opportunistic and vaccine-preventable infections after allogeneic haemopoietic stem cell transplantation' Clinical and Translational Immunology, vol. 7, no. 10, e1040. https://doi.org/10.1002/cti2.1040

De Silva, H, Ffrench, RA, Korem, M, Orlowski-Oliver, E, Curtis, DJ, Spencer, A, Avery, S, Patil, S & Morrissey, CO 2018, 'Contemporary analysis of functional immune recovery to opportunistic and vaccine-preventable infections after allogeneic haemopoietic stem cell transplantation' Clinical and Translational Immunology, vol. 7, no. 10, e1040. https://doi.org/10.1002/cti2.1040

Dingjan, T, Gillon, É, Imberty, A, Pérez, S, Titz, A, Ramsland, PA & Yuriev, E 2018, 'Virtual Screening Against Carbohydrate-Binding Proteins: Evaluation and Application to Bacterial Burkholderia ambifaria Lectin' Journal of Chemical Information and Modeling, vol. 58, no. 9, pp. 1976-1989. https://doi.org/10.1021/acs.jcim.8b00185

Dingjan, T, Gillon, É, Imberty, A, Pérez, S, Titz, A, Ramsland, PA & Yuriev, E 2018, 'Virtual Screening Against Carbohydrate-Binding Proteins: Evaluation and Application to Bacterial Burkholderia ambifaria Lectin' Journal of Chemical Information and Modeling, vol. 58, no. 9, pp. 1976-1989. https://doi.org/10.1021/acs.jcim.8b00185

Dingjan, T, Gillon, É, Imberty, A, Pérez, S, Titz, A, Ramsland, PA & Yuriev, E 2018, 'Virtual Screening Against Carbohydrate-Binding Proteins: Evaluation and Application to Bacterial Burkholderia ambifaria Lectin' Journal of Chemical Information and Modeling, vol. 58, no. 9, pp. 1976-1989. https://doi.org/10.1021/acs.jcim.8b00185

Dubsky, S, Thurgood, J, Fouras, A, Thompson, BR & Sheard, GJ 2018, 'Cardiogenic Airflow in the Lung Revealed Using Synchrotron-Based Dynamic Lung Imaging' Scientific Reports, vol. 8, no. 1, 4930. https://doi.org/10.1038/s41598-018-23193-w

Edwards, ESJ, Bier, J, Cole, TS, Wong, M, Hsu, P, Berglund, LJ, Boztug, K, Lau, A, Gostick, E, Price, DA, O'Sullivan, M, Meyts, I, Choo, S, Gray, P, Holland, SM, Deenick, EK, Uzel, G & Tangye, SG 2018, 'Activating PIK3CD mutations impair human cytotoxic lymphocyte differentiation and function and EBV immunity' Journal of Allergy and Clinical Immunology. https://doi.org/10.1016/j.jaci.2018.04.030

Galvão, I, Tavares, LP, Corrêa, RO, Fachi, JL, Rocha, VM, Rungue, M, Garcia, CC, Cassali, G, Ferreira, CM, Martins, FS, Oliveira, SC, Mackay, CR, Teixeira, MM, Vinolo, MAR & Vieira, AT 2018, 'The metabolic sensor GPR43 receptor plays a role in the control of Klebsiella pneumoniae infection in the lung' Frontiers in Immunology, vol. 9, 142. https://doi.org/10.3389/fimmu.2018.00142

Gao, Q, Xiang, SD, Wilson, K, Madondo, M, Stephens, AN & Plebanski, M 2018, 'Sperm protein 17 expression by murine epithelial ovarian cancer cells and its impact on tumor progression' Cancers, vol. 10, no. 8, 276. https://doi.org/10.3390/cancers10080276

Guy, AJ, Irani, V, Beeson, JG, Webb, B, Sali, A, Richards, JS & Ramsland, PA 2018, 'Proteome-wide mapping of immune features onto Plasmodium protein three-dimensional structures' Scientific Reports, vol. 8, no. 1, 4355. https://doi.org/10.1038/s41598-018-22592-3

Hawkey, J, Ascher, DB, Judd, LM, Wick, RR, Kostoulias, X, Cleland, H, Spelman, DW, Padiglione, A, Peleg, AY & Holt, KE 2018, 'Evolution of carbapenem resistance in Acinetobacter baumannii during a prolonged infection' Microbial genomics, vol. 4, no. 3.

Heeringa, JJ, Karim, AF, van Laar, JAM, Verdijk, RM, Paridaens, D, van Hagen, PM & van Zelm, MC 2018, 'Expansion of blood IgG4 + B, TH2, and regulatory T cells in patients with IgG4-related disease' Journal of Allergy and Clinical Immunology, vol. 141, no. 5, pp. 1831-1843.e10. https://doi.org/10.1016/j.jaci.2017.07.024

Jansen, MAE, van Zelm, M, Groeneweg, M, Jaddoe, VWV, Dik, WA, Schreurs, MWJ, Hooijkaas, H, Moll, H & Escher, JC 2018, 'The identification of celiac disease in asymptomatic children: the Generation R Study' Journal of Gastroenterology, vol. 53, no. 3, pp. 377-386. https://doi.org/10.1007/s00535-017-1354-x

Kampan, NC, Xiang, SD, McNally, OM, Stephens, AN, Quinn, MA & Plebanski, M 2018, 'Immunotherapeutic Interleukin-6 or Interleukin-6 Receptor Blockade in Cancer: Challenges and Opportunities' Current Medicinal Chemistry, vol. 25, no. 36, pp. 4785-4806. https://doi.org/10.2174/0929867324666170712160621

Kara, EE, Bastow, CR, McKenzie, DR, Gregor, CE, Fenix, KA, Babb, R, Norton, TS, Zotos, D, Rodda, LB, Hermes, JR, Bourne, K, Gilchrist, DS, Nibbs, RJ, Alsharifi, M, Vinuesa, CG, Tarlinton, DM, Brink, R, Hill, GR, Cyster, JG, Comerford, I & McColl, SR 2018, 'Atypical chemokine receptor 4 shapes activated B cell fate' Journal of Experimental Medicine, vol. 215, no. 3, pp. 801-813. https://doi.org/10.1084/jem.20171067

Kraakman, MJ, Kammoun, HL, Dragoljevic, D, Al-Sharea, A, Lee, MKS, Flynn, MC, Stolz, CJ, Guirguis, AA, Lancaster, GI, Chin-Dusting, J, Curtis, DJ & Murphy, AJ 2018, 'Leptin-deficient obesity prolongs survival in a murine model of myelodysplastic syndrome' Haematologica: the hematology journal, vol. 103, no. 4, pp. 597-606. https://doi.org/10.3324/haematol.2017.181958

Kurtovic, L, Behet, MC, Feng, G, Reiling, L, Chelimo, K, Dent, AE, Mueller, I, Kazura, JW, Sauerwein, RW, Fowkes, FJI & Beeson, JG 2018, 'Human antibodies activate complement against Plasmodium falciparum sporozoites, and are associated with protection against malaria in children' BMC Medicine, vol. 16, no. 1, 61. https://doi.org/10.1186/s12916-018-1054-2

Lam, MMC, Wick, RR, Wyres, KL, Gorrie, CL, Judd, LM, Jenney, AWJ, Brisse, S & Holt, KE 2018, 'Genetic diversity, mobilisation and spread of the yersiniabactin-encoding mobile element ICEKp in Klebsiella pneumoniae populations' Microbial genomics, vol. 4, no. 9. https://doi.org/10.1099/mgen.0.000196

Lam, MMC, Wyres, KL, Duchêne, S, Wick, RR, Judd, LM, Gan, YH, Hoh, CH, Archuleta, S, Molton, JS, Kalimuddin, S, Koh, TH, Passet, V, Brisse, S & Holt, KE 2018, 'Population genomics of hypervirulent Klebsiella pneumoniae clonal-group 23 reveals early emergence and rapid global dissemination' Nature Communications, vol. 9, no. 1, 2703. https://doi.org/10.1038/s41467-018-05114-7

Lancaster, GI, Langley, KG, Berglund, NA, Kammoun, HL, Reibe, S, Estevez, E, Weir, J, Mellett, NA, Pernes, G, Conway, JRW, Lee, MKS, Timpson, P, Murphy, AJ, Masters, SL, Gerondakis, S, Bartonicek, N, Kaczorowski, DC, Dinger, ME, Meikle, PJ, Bond, PJ & Febbraio, MA 2018, 'Evidence that TLR4 Is Not a Receptor for Saturated Fatty Acids but Mediates Lipid-Induced Inflammation by Reprogramming Macrophage Metabolism' Cell Metabolism, vol. 27, no. 5, pp. 1096-1110. https://doi.org/10.1016/j.cmet.2018.03.014

Li, J, Huynh, P, Dai, A, Wu, T, Tu, Y, Chow, B, Kiriazis, H, Du, XJ, Bach, LA, Wilkinson-Berka, JL, Biros, E, Walker, P, Nataatmadja, M, West, M, Golledge, J, Allen, TJ, Cooper, ME & Chai, Z 2018, 'Diabetes reduces severity of aortic aneurysms depending on the presence of cell division autoantigen 1 (CDA1)' Diabetes, vol. 67, no. 4, pp. 755-768. https://doi.org/10.2337/db17-0134

Lucas, M, Deshpande, P, James, I, Rauch, A, Pfafferott, K, Gaylard, E, Merani, S, Plauzolles, A, Lucas, A, McDonnell, W, Kalams, S, Pilkinton, M, Chastain, C, Barnett, L, Prosser, A, Mallal, S, Fitzmaurice, K, Drummer, H, Ansari, MA, Pedergnana, V, Barnes, E, John, M, Kelleher, D, Klenerman, P & Gaudieri, S 2018, 'Evidence of CD4+ T cell-mediated immune pressure on the Hepatitis C virus genome' Scientific Reports, vol. 8, no. 1, 7224. https://doi.org/10.1038/s41598-018-25559-6

Ma, Q, Huang, Y, Wang, J, Xu, X, Hawkey, J, Yang, C, Liang, B, Hu, X, Wu, F & Yang, X 2018, 'Multidrug-resistant Shigella sonnei carrying plasmid-mediated mcr-1 gene in China' International Journal of Antimicrobial Agents.

Mokhtar, SH, Kim, MJ, Magee, KA, Aui, PM, Thomas, S, Bakhuraysah, MM, Alrehaili, AA, Lee, JY, Steer, DL, Kenny, R, McLean, C, Azari, MF, Birpanagos, A, Lipiec, E, Heraud, P, Wood, B & Petratos, S 2018, 'Amyloid-beta-dependent phosphorylation of collapsin response mediator protein-2 dissociates kinesin in Alzheimer's disease' Neural Regeneration Research, vol. 13, no. 6, 29926835, pp. 1066-1080. https://doi.org/10.4103/1673-5374.233451

O'Reilly, LA, Putoczki, TL, Mielke, LA, Low, JT, Lin, A, Preaudet, A, Herold, MJ, Yaprianto, K, Tai, L, Kueh, A, Pacini, G, Ferrero, RL, Gugasyan, R, Hu, Y, Christie, M, Wilcox, S, Grumont, R, Griffin, MDW, O'Connor, L, Smyth, GK, Ernst, M, Waring, P, Gerondakis, S & Strasser, A 2018, 'Loss of NF-κB1 Causes Gastric Cancer with Aberrant Inflammation and Expression of Immune Checkpoint Regulators in a STAT-1-Dependent Manner' Immunity, vol. 48, no. 3, pp. 570-583. https://doi.org/10.1016/j.immuni.2018.03.003

Pattaroni, C, Watzenboeck, ML, Schneidegger, S, Kieser, S, Wong, NCL, Bernasconi, E, Pernot, J, Mercier, L, Knapp, S, Nicod, LP, Marsland, CP, Roth-Kleiner, M & Marsland, BJ 2018, 'Early-Life Formation of the Microbial and Immunological Environment of the Human Airways' Cell Host and Microbe, vol. 24, no. 6.

Pattaroni, C, Watzenboeck, ML, Schneidegger, S, Kieser, S, Wong, NCL, Bernasconi, E, Pernot, J, Mercier, L, Knapp, S, Nicod, LP, Marsland, CP, Roth-Kleiner, M & Marsland, BJ 2018, 'Early-Life Formation of the Microbial and Immunological Environment of the Human Airways' Cell Host and Microbe, vol. 24, no. 6.

Rapin, A & Harris, NL 2018, 'Helminth–Bacterial Interactions: Cause and Consequence' Trends in Immunology, pp. 1-10. https://doi.org/10.1016/j.it.2018.06.002

Slade, CA, Bosco, JJ, Giang, TB, Kruse, E, Stirling, RG, Cameron, PU, Hore-Lacy, F, Sutherland, MF, Barnes, SL, Holdsworth, S, Ojaimi, S, Unglik, GA, De Luca, J, Patel, M, McComish, J, Spriggs, K, Tran, Y, Auyeung, P, Nicholls, K, O'Hehir, RE, Hodgkin, PD, Douglass, JA, Bryant, VL & van Zelm, MC 2018, 'Delayed diagnosis and complications of predominantly antibody deficiencies in a cohort of Australian adults' Frontiers in Immunology, vol. 9, no. MAY, 694. https://doi.org/10.3389/fimmu.2018.00694

Slade, CA, Bosco, JJ, Giang, TB, Kruse, E, Stirling, RG, Cameron, PU, Hore-Lacy, F, Sutherland, MF, Barnes, SL, Holdsworth, S, Ojaimi, S, Unglik, GA, De Luca, J, Patel, M, McComish, J, Spriggs, K, Tran, Y, Auyeung, P, Nicholls, K, O'Hehir, RE, Hodgkin, PD, Douglass, JA, Bryant, VL & van Zelm, MC 2018, 'Delayed diagnosis and complications of predominantly antibody deficiencies in a cohort of Australian adults' Frontiers in Immunology, vol. 9, no. MAY, 694. https://doi.org/10.3389/fimmu.2018.00694

Soliman, C, Walduck, AK, Yuriev, E, Richards, JS, Cywes-Bentley, C, Pier, GB & Ramsland, PA 2018, 'Structural basis for antibody targeting of the broadly expressed microbial polysaccharide poly-N-acetylglucosamine' Journal of Biological Chemistry, vol. 293, no. 14, pp. 5079-5089. https://doi.org/10.1074/jbc.RA117.001170

the Measurement of Exercise Tolerance for Surgery Study Investigators 2018, 'Using the 6-minute walk test to predict disability-free survival after major surgery' British Journal of Anaesthesia. https://doi.org/10.1016/j.bja.2018.08.016

Trompette, A, Gollwitzer, ES, Pattaroni, C, Lopez-Mejia, IC, Riva, E, Pernot, J, Ubags, N, Fajas, L, Nicod, LP & Marsland, BJ 2018, 'Dietary Fiber Confers Protection against Flu by Shaping Ly6c− Patrolling Monocyte Hematopoiesis and CD8+ T Cell Metabolism' Immunity, vol. 48, no. 5, pp. 992-1005.e8. https://doi.org/10.1016/j.immuni.2018.04.022

Vincent, FB, Kandane-Rathnayake, R, Hoi, AY, Slavin, L, Godsell, JD, Kitching, AR, Harris, J, Nelson, CL, Jenkins, AJ, Chrysostomou, A, Hibbs, ML, Kerr, PG, Rischmueller, M, Mackay, F & Morand, EF 2018, 'Urinary B-cell-activating factor of the tumour necrosis factor family (BAFF) in systemic lupus erythematosus' Lupus, vol. 27, no. 13, pp. 2029-2040. https://doi.org/10.1177/0961203318804885

Vincent, FB, Slavin, L, Hoi, AY, Kitching, AR, Mackay, F, Harris, J, Kandane-Rathnayake, R & Morand, EF 2018, 'Analysis of urinary macrophage migration inhibitory factor in systemic lupus erythematosus' Lupus Science and Medicine, vol. 5, no. 1, e000277. https://doi.org/10.1136/lupus-2018-000277

Vincent, FB, Slavin, L, Hoi, AY, Kitching, AR, Mackay, F, Harris, J, Kandane-Rathnayake, R & Morand, EF 2018, 'Analysis of urinary macrophage migration inhibitory factor in systemic lupus erythematosus' Lupus Science and Medicine, vol. 5, no. 1, e000277. https://doi.org/10.1136/lupus-2018-000277

Wallin, EF, Hill, DL, Linterman, MA & Wood, KJ 2018, 'The calcineurin inhibitor tacrolimus specifically suppresses human T follicular helper cells' Frontiers in Immunology, vol. 9, no. MAY, 1184. https://doi.org/10.3389/fimmu.2018.01184

Wallin, EF, Hill, DL, Linterman, MA & Wood, KJ 2018, 'The calcineurin inhibitor tacrolimus specifically suppresses human T follicular helper cells' Frontiers in Immunology, vol. 9, no. MAY, 1184. https://doi.org/10.3389/fimmu.2018.01184

Wilson, AL, Moffitt, LR, Duffield, N, Rainczuk, A, Jobling, TW, Plebanski, M & Stephens, AN 2018, 'Autoantibodies against HSF1 and CCDC155 as biomarkers of early-Stage, high-Grade serous ovarian cancer' Cancer Epidemiology Biomarkers and Prevention, vol. 27, no. 2, pp. 183-192. https://doi.org/10.1158/1055-9965.EPI-17-0752

Wines, BD, Tan, CW, Duncan, E, McRae, S, Baker, RI, Andrews, RK, Esparon, S, Gardiner, EE & Hogarth, PM 2018, 'Dimeric FcγR ectodomains detect pathogenic anti-platelet factor 4–heparin antibodies in heparin-induced thromobocytopenia' Journal of Thrombosis and Haemostasis, vol. 16, no. 12, pp. 2520-2525. https://doi.org/10.1111/jth.14306

Zanker, D, Pang, K, Oveissi, S, Lu, C, Faou, P, Nowell, C, Mbogo, GW, Carotta, S, Quillici, C, Karupiah, G, Hibbs, ML, Nutt, SL, Neeson, P, Puthalakath, H & Chen, W 2018, 'LMP2 immunoproteasome promotes lymphocyte survival by degrading apoptotic BH3-only proteins' Immunology and Cell Biology, vol. 96, no. 9, pp. 981-993. https://doi.org/10.1111/imcb.12163