Class 1b MHC laboratory - Andrews

Key words: NK, Natural Killer cells, white blood cells, class 1b MHC

2018. Top L-R: Ms Angela Nguyen, Dr Katharine Goodall, Ms Mahtab Parvaresh
Bottom L-R: Ms Anisha Ansari, Dr Dan Andrews, Mr Dan Thiele, Ms Isobel Leece


The Class 1b MHC Laboratory focuses on the interaction between lymphoid cell receptors and non-classical MHC. The focus is on understanding the biochemistry, cell biology and immune responses associated with these interactions.

Immune detection and eradication or control of cancer and cancer immunotherapies are based in part on the idea that tumour-specific white blood cells can protect the body from tumour development, growth and metastases. While strong evidence supports this, the means by which these white cells first recognize the cancerous tissue is largely unknown. We are studying a new family of white blood cell receptors that may be important in this recognition, either naturally or following therapy.

Research Projects for Students

  1. What can the class Ib MHC teach us about immune responses?
  2. Co-evolution of the class Ib MHC with viruses


See Pubmed search, Andrews DM [Author].


  • NHMRC Project Grant 1028425: How Natural Killers do their thing
  • NHMRC Project Grant: The unique nature of gamma delta T cell recognition resolved through interaction with H2-Q10