Multiple sclerosis

The focus of our research is understand the cellular and molecular mechanisms of MS relapse (disease flares). We also aim to understand how the various disease-modifying therapies for MS affect the peripheral immune responses and its translation into clinical outcomes.

Multiple sclerosis (MS) is a disease in which the immune system attacks the protective coverings (myelin) of the nerves. It is characterized by plaques in various regions of the brain and spinal cord, leading to physical disability, cognitive and memory impairment as well psychiatric problems such as depression and anxiety. MS relapse is characterised by a flare or deterioration of the condition that can be diagnosed clinically and in some cases associated with presence of new lesions on MRI scan. Currently there are no accurate biomarkers of MS relapse and we do not have targeted therapies for MS flare. We hope our research can assist in not only improving our understanding of MS flare, but the knowledge gained could lead to targeted therapies to combat disease flare.

Our group is also involved in clinical trials examining the effect of various MS therapies on peripheral immunity.

News highlights

  • See a summary given by Dr Monif about her research here.
  • Multiple Sclerosis team improved patient care under pandemic conditions. Find out more