2017 BMedSci Honours students
A brief intervention for obesity in a tertiary hospital
Supervisor Professor Wendy Brown, Kirsten Corben.
A brief intervention for obesity in a tertiary hospital is a pilot trial at The Alfred Hospital aiming to determine whether doctor-led discussion and education with patients in hospital leads to more weight management attempts in the community setting. Overweight and obesity are increasingly common in the Australian population, affecting almost two thirds of adults. Obesity, defined as excessive fat accumulation which may impair health and determined with a BMI>30 kg/m2, often leads to many diseases including heart disease, type 2 diabetes, osteoarthritis, sleep apnoea, fertility problems and even increases the risk of certain cancers. The ideal management of obesity is weight loss and the spectrum of treatments offered to achieve weight loss ranges from simple lifestyle advice to bariatric surgery. In this project, we explore the effects of making that first step of recognising weight as a health issue and giving simple advice, a standard part of patient care, in order to encourage behaviour changes and promote obesity on the health promotion agenda.
Examining the inflammatory profile in adipose tissue in oesophageal cancer
Supervisors: Mr Paul Burton, Professor Matt Watt, Professor Wendy Brown.
Oesophageal adenocarcinoma is one the cancers most closely associated with obesity and has demonstrated a 400% increase over the past 30 years. The reasons for this association is unknown. It is strongly suspected that visceral fat creates an inflammatory process that significantly favours the development of oesophageal cancer and other cancers. The inflammatory profile, visceral and preoteonomic profile present in the visceral fat of patients with oesophageal cancer has not previously been described. Dysregulation of fat metabolism in adipose tissue located adjacent to the oesophagus may contribute to the development of oesophageal cancer. This PhD will seek to better understand the lipid profile, particularly visceral that may be leading to the observed increase susceptibility to oesophageal adenocarcinoma.
2017 Honours student
William de Nardo
Examining the metabolic profile in Oesophageal Carcinomas
Supervisors: Professor Matt Watt, Mr Paul Burton.
Oesophageal cancers are responsible for 400,000 deaths annually. Examining how the two prominent oesophageal cancers, adenocarcinoma and squamous cell carcinoma, metabolise their nutrients is essential in comprehending how they grow and therefore how to block it. Currently, the role that fatty acids play in fuelling cancer growth in oesophageal adenocarcinomas and squamous cell carcinomas is yet to be characterized. In this project, we aim to determine how and to what extent do these oesophageal cancers, store or utilize fatty acids as an energy source. Consequently, allowing for the development of potential targeted anti-cancer therapies in squamous cell and adenocarcinoma.
Are you interested in completing a PhD with CORE?
Please contact one of the stream leaders to discuss potential PhD projects at CORE. Students will be enrolled through the School of Public Health and Preventive Medicine and will be based at the Alfred site.
Clinical Research - Prof Wendy Brown at firstname.lastname@example.orgPhysiological Research - Mr Paul Burton at email@example.comPsychological and Psychosocial Research - Dr Leah Brennan at firstname.lastname@example.org
For further information on the School of Public Health and Preventive Medicine, please visit the SPHPM page.
Past Doctoral Students
Mr Paul Burton MBBS(hons) PhD FRACS
The physiology and pathophysiology of laparoscopic adjustable gastric bands
Supervisors: Prof Wendy Brown and Prof Paul O'Brien
Burton PR, Brown WA, Laurie C, Lee M, Korin A, Anderson M, Hebbard G, O'Brien PE. Outcomes, Satiety, and Adverse Upper Gastrointestinal Symptoms Following Laparoscopic Adjustable Gastric Banding. Obesity Surgery. 2011. 21(5):574-81.
Burton PR, Yap K, Brown WA, Laurie C, O'Donnell M, Hebbard G, Kalff V, O'Brien PE. Changes in Satiety, Supra- and Infraband Transit, and Gastric Emptying Following Laparoscopic Adjustable Gastric Banding: A Prospective Follow-up Study. Obesity Surgery. 2011;21(2):217-23.
Burton PR, Yap K, Brown WA, Laurie C, O'Donnell M, Hebbard G, Kalff V, O'Brien PE. Effects of Adjustable Gastric Bands on Gastric Emptying, Supra- and Infraband Transit and Satiety: A Randomized Double-Blind Crossover Trial Using a New Technique of Band Visualization. Obesity Surgery. 2010; 20(12):1690-7.
Burton PR, Brown WA, Laurie C, Hebbard G, O'Brien PE. Predicting Outcomes of Intermediate Term Complications and Revisional Surgery Following Laparoscopic Adjustable Gastric Banding: Utility of the CORE Classification and Melbourne Motility Criteria. Obesity Surgery. 2010; 20(11):1516-23.
Burton PR, Brown WA, Laurie C, Hebbard G, O'Brien PE. Mechanisms of Bolus clearance in patients with Laparoscopic Adjustable Gastric Bands. Obesity Surgery. 2010; 20(9):1265-72.
Burton PR, Brown WA, Laurie C, Hebbard G, O'Brien PE. Criteria for Assessing Esophageal Motility in Laparoscopic Adjustable Gastric Band Patients: The Importance of the Lower Esophageal Contractile Segment. Obesity Surgery. 2010, 20(3): 316-25.
Burton PR, Brown WA, Laurie C, Korin A, Yap K, Richards M, Owens J, Crosthwaite G, Hebbard G, O'Brien PE. Pathophysiology of Laparoscopic Adjustable Gastric Bands: Analysis and Classification Using High-Resolution Video Manometry and a Stress Barium Protocol. Obesity Surgery. 2010, 20(1):19-29.
Burton PR, Brown WA, Laurie C, Richards M, Hebbard G, O'Brien PE. Effects of Gastric Band Adjustments on Intraluminal Pressure. Obesity Surgery. 2009; 19(11):1508-1514.
Burton PR, Brown W, Laurie C, Richards M, Afkari S, Yap K, Korin A, Hebbard G, O'Brien PE. The Effect of Laparoscopic Adjustable Gastric Bands on Esophageal Motility and the Gastroesophageal Junction: Analysis Using High-Resolution Video Manometry. Obesity Surgery 2009, 19(7):905-914.