Grant for investigating new treatment target for chronic blood cancers

Congratulations to Dr Andrew Perkins, Australian Centre for Blood Diseases, on the award of a grant from the Victorian Cancer Agency to investigate a new target for treatment of chronic blood cancers known as myeloproliferative neoplasms.

Dr Andrew Perkins (pictured with his group, 4th from left) has been awarded $293,000 over three years (2020-2022) for his application "Validation of new druggable JAK-STAT targets in myeloproliferative neoplasms". The funding is made via the Cancer Council Victoria Grants-in-Aid grant program.

Dr Perkins said that they have employed genomics techniques to discover new direct JAK-STAT target genes, which drive excess blood production in chronic blood cancers. "This project will test whether targeting two of these new genes, using CRISPR [a family of DNA sequences] gene editing or drugs, can improve survival in mouse models of blood cancer. We will also test whether expression of these genes will provide useful biomarkers of disease activity in patients," he said.

See more about the Perkins research group.