Publications

The Monash Health Vasculitis Clinic

World-class research and treatment of kidney disease
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Autoimmune Kidney Disease and Vasculitis Research Group

Below is the list of selected publications. Click HERE for all current publications.

Selected publications

Mast Cell Stabilization Ameliorates Autoimmune Anti-Myeloperoxidase Glomerulonephritis.
Gan PY, O'Sullivan KM, Ooi JD, Alikhan MA, Odobasic D, Summers SA, Kitching AR, Holdsworth SR.
J Am Soc Nephrol. 2015 Sep 15. pii: ASN.2014090906.

Renal participation of myeloperoxidase in antineutrophil cytoplasmic antibody (ANCA)-associated glomerulonephritis.
O'Sullivan KM, Lo CY, Summers SA, Elgass KD, McMillan PJ, Longano A, Ford SL, Gan PY, Kerr PG,Kitching AR, Holdsworth SR.
Kidney Int. 2015 Nov;88(5):1030-46. doi: 10.1038/ki.2015.202. Epub 2015 Jul 15.

Endogenous Toll-Like Receptor 9 Regulates AKI by Promoting Regulatory T Cell Recruitment.
Alikhan MA, Summers SA, Gan PY, Chan AJ, Khouri MB, Ooi JD, Ghali JR, Odobasic D, Hickey MJ,Kitching AR, Holdsworth SR.
J Am Soc Nephrol. 2015 Jun 26.

Myeloperoxidase Peptide-Based Nasal Tolerance in Experimental ANCA-Associated GN.
Gan PY, Tan DS, Ooi JD, Alikhan MA, Kitching AR, Holdsworth SR.
J Am Soc Nephrol. 2015 Jun 5. pii: ASN.2015010089. [Epub ahead of print]

FMS-like tyrosine kinase 3 ligand treatment does not ameliorate experimental rapidly progressive glomerulonephritis.
Ghali JR, O'Sullivan KM, Eggenhuizen PJ, Holdsworth SR, Kitching AR.
PLoS One. 2015 Apr 7;10(4):e0123118. doi: 10.1371/journal.pone.0123118. eCollection 2015.

Suppression of Autoimmunity and Renal Disease in Pristane-Induced Lupus by Myeloperoxidase.
Odobasic D, Muljadi RC, O'Sullivan KM, Kettle AJ, Dickerhof N, Summers SA, Kitching AR,Holdsworth SR.
Arthritis Rheumatol. 2015 Jul;67(7):1868-80. doi: 10.1002/art.39109.

Mouse models of anti-neutrophil cytoplasmic antibody-associated vasculitis.
Gan PY, Ooi JD, Kitching AR, Holdsworth SR.
Curr Pharm Des. 2015;21(18):2380-90.

T cell mediated autoimmune glomerular disease in mice.
Ooi JD, Gan PY, Odobasic D, Holdsworth SR, Kitching AR.
Curr Protoc Immunol. 2014 Nov 3;107:Unit 15.27.. doi: 10.1002/0471142735.im1527s107.

Glomerulonephritis Induced by Heterologous Anti-GBM Globulin as a Planted Foreign Antigen.
Odobasic D, Ghali JR, O'Sullivan KM, Holdsworth SR, Kitching AR.
Curr Protoc Immunol. 2014 Aug 1;106:15.26.1-15.26.20. doi: 10.1002/0471142735.im1526s106.
PMID: 25081909

FcγRIIB regulates T-cell autoreactivity, ANCA production, and neutrophil activation to suppress anti-myeloperoxidase glomerulonephritis.
Ooi JD, Gan PY, Chen T, Eggenhuizen PJ, Chang J, Alikhan MA, Odobasic D, Holdsworth SR,Kitching AR.
Kidney Int. 2014 Dec;86(6):1140-9. doi: 10.1038/ki.2014.189. Epub 2014 May 28.

Endogenous myeloperoxidase is a mediator of joint inflammation and damage in experimental arthritis.
Odobasic D, Yang Y, Muljadi RC, O'Sullivan KM, Kao W, Smith M, Morand EF, Holdsworth SR.
Arthritis Rheumatol. 2014 Apr;66(4):907-17. doi: 10.1002/art.38299.

Innate IL-17A-producing leukocytes promote acute kidney injury via inflammasome and Toll-like receptor activation.
Chan AJ, Alikhan MA, Odobasic D, Gan PY, Khouri MB, Steinmetz OM, Mansell AS, Kitching AR,Holdsworth SR, Summers SA.
Am J Pathol. 2014 May;184(5):1411-8. doi: 10.1016/j.ajpath.2014.01.023. Epub 2014 Mar 14.
PMID: 24631024

Histopathologic and clinical predictors of kidney outcomes in ANCA-associated vasculitis.
Ford SL, Polkinghorne KR, Longano A, Dowling J, Dayan S, Kerr PG, Holdsworth SR, Kitching AR, Summers SA.
Am J Kidney Dis. 2014 Feb;63(2):227-35. doi: 10.1053/j.ajkd.2013.08.025. Epub 2013 Oct 30.
PMID: 24183110

Neutrophil myeloperoxidase regulates T-cell-driven tissue inflammation in mice by inhibiting dendritic cell function.
Odobasic D, Kitching AR, Yang Y, O'Sullivan KM, Muljadi RC, Edgtton KL, Tan DS, Summers SA, Morand EF, Holdsworth SR.
Blood. 2013 May 16;121(20):4195-204. doi: 10.1182/blood-2012-09-456483. Epub 2013 Mar 18.

The HLA-DRB1*15:01-restricted Goodpasture's T cell epitope induces GN.
Ooi JD, Chang J, O'Sullivan KM, Pedchenko V, Hudson BG, Vandenbark AA, Fugger L, Holdsworth SR, Kitching AR.
J Am Soc Nephrol. 2013 Feb;24(3):419-31. doi: 10.1681/ASN.2012070705. Epub 2013 Feb 14.
PMID: 23411782
 
Multiphoton imaging reveals a new leukocyte recruitment paradigm in the glomerulus.
Devi S, Li A, Westhorpe CL, Lo CY, Abeynaike LD, Snelgrove SL, Hall P, Ooi JD, Sobey CG, Kitching AR, Hickey MJ.
Nat Med. 2013 Jan;19(1):107-12. doi: 10.1038/nm.3024. Epub 2012 Dec 16.

The immunodominant myeloperoxidase T-cell epitope induces local cell-mediated injury in antimyeloperoxidase glomerulonephritis.
Ooi JD, Chang J, Hickey MJ, Borza DB, Fugger L, Holdsworth SR, Kitching AR.
Proc Natl Acad Sci U S A. 2012 Sep 25;109(39):E2615-24. Epub 2012 Sep 5.

Endogenous IL-17A promotes pristane-induced systemic autoimmunity and lupus nephritis induced by pristane.
Summers SA, Odobasic D, Khouri MB Steinmetz OM, Yang Y, Holdsworth SR Kitching AR.
Clin Exp Immunol 2014, 176(3):341-50.

Epitope specificity determines pathogenicity and detectability in ANCA-associated vasculitis.
Roth A, Ooi JD, Hess JJ, van Timmeren MM, Berg EA, Jennette CE, McGregor JA, Burkart M, Hogan SL, HU Y, Winnik W, Nachman PH, Stegeman CA, Heeringa P, Kitching AR, Holdsworth SR, Jennette JC, Preston GA, Falk RJ.
J Clin Invest 123: 1773-83, 2013.