Leukocyte Trafficking Group
About the Leukocyte Trafficking Group
Leukocytes play critical roles in protective responses to infection and injury. However, these same cells are also major contributors to inappropriate, damaging responses in inflammatory diseases. Our laboratory studies the actions of leukocytes in models of inflammatory disease, using state-of-the-art imaging systems such as multiphoton microscopy to directly visualise leukocytes in vivo during their recruitment from the bloodstream, and following their entry into tissues.
The recruitment of leukocytes via interactions with the endothelial vascular lining and the subsequent actions of these cells drives inflammatory injury, and is a common pathway to tissue injury in inflammatory diseases. Studying these processes in real time in living tissues allows mechanisms of injury to be defined and new therapies developed.
Professor Michael Hickey
After completing his PhD at the University of Melbourne in 1996, Michael Hickey underwent postdoctoral training in the Immunology Research Group at the University of Calgary in Canada (1996-1999) and the Baker Heart Research Institute (2000-2001), before joining the Centre for Inflammatory Diseases at Monash University in August 2001.
Find out more about Professor Michael Hickey.
Click here for more information on the members of the Leukocyte Trafficking Group
Research interests of the lab include:
- Mechanisms of Leukocyte Recruitment
- Immune cell interactions in the inflamed glomerulus
- Leukocyte-platelet interactions in the inflamed vasculature
- Regulatory T cell recruitment and function in inflammatory skin disease
- Roles of tetraspanin family members in leukocyte migration
Find out more about our research.
Leukocyte Trafficking Group – highlighted publications since 2006
Westhorpe CLV, Bayard JE, O’Sullivan KM, Hall P, Cheng Q, Kitching AR, Hickey MJ. In vivo imaging of inflamed glomeruli reveals dynamics of neutrophil extracellular trap formation in glomerular capillaries. Am. J. Pathol. (2017) 187: 318-331.
Finsterbusch M, Hall P, Li A, Devi S, Westhorpe CLV, Kitching AR, Hickey MJ. Patrolling monocytes promote intravascular neutrophil activation and glomerular injury in the acutely-inflamed glomerulus. Proc. Natl. Acad. Sci. USA (2016) 113: E5172-81.
Snelgrove SL, Lo C, Hall P, Lo CY, Alikhan MA, Coates PT, Holdsworth SR, Hickey MJ*, Kitching AR*. Activated renal dendritic cells cross present intrarenal antigens after ischemia reperfusion injury. Transplantation (2017) 101: 1013-1024. *Co-senior authors.
Abeynaike LD, Deane JA, Westhorpe CLV, Chow Z, Alikhan MA, Kitching AR, Issekutz A, Hickey MJ. Regulatory T cells dynamically regulate selectin ligand function during multiple challenge contact hypersensitivity. J. Immunol. (2014) 193: 4934-4944.
Chow Z, Mueller SN, Deane JA*, Hickey MJ*. Dermal regulatory T cells display distinct migratory behavior that is modulated during adaptive and innate inflammation. J. Immunol. (2013) 191: 3049-3056. *Co-senior authors.
Devi S, Li A, Westhorpe CLV, Lo CY, Abeynaike LD, Snelgrove SL, Hall P, Ooi JD, Sobey CG, Kitching AR, Hickey MJ. Multiphoton imaging reveals a novel leukocyte recruitment paradigm in the glomerulus. Nat Med (2013) 19: 107-12.
Deane JA, Abeynaike LD, Norman MU, Wee JL, Kitching AR, Kubes P, Hickey MJ. Endogenous T regulatory cells adhere in inflamed dermal vessels via ICAM-1 – association with regulation of effector leukocyte adhesion. J. Immunol (2012) 188: 2179-88.
Cheng Q, McKeown SJ, Santos L, Santiago FS, Khachigian LM, Morand EF, Hickey MJ. Macrophage migration inhibitory factor increases leukocyte-endothelial interactions in human endothelial cells via promotion of expression of adhesion molecules. J. Immunol. (2010) 185: 1238–1247.
Kuligowski MP, Kwan RYQ, Lo C, Wong C, James WG, Bourges D, Ooi JD, Abeynaike L, Hall P, Kitching AR, Hickey MJ. Anti-myeloperoxidase antibodies rapidly induce 4 integrin-dependent glomerular neutrophil adhesion. Blood (2009) 113: 6485-94.
Gregory JL, Morand EF, McKeown SJ, Ralph JA, Hall P, Yang YH, McColl SR, Hickey MJ. Macrophage migration inhibitory factor induces macrophage recruitment via CC chemokine ligand 2. J. Immunol. (2006) 177: 8072-8079.
Hoi AY, Hickey MJ, Hall P, Yamana J, O’Sullivan K, Santos LL, Foote A, James WG, Kitching AR, Morand EF. MIF deficiency attenuates macrophage recruitment, glomerulonephritis and lethality in MRL/lpr mice. J. Immunol. (2006) 177: 5687-5696.
Kuligowski MP, Kitching AR, Hickey MJ. Leukocyte recruitment to the inflamed glomerulus: a critical role for platelet-derived P-selectin, in the absence of rolling. J. Immunol. (2006) 176: 6991-6999.
If you are thinking of a career in biomedical research The School of Clinical Sciences is a great place to start. We are located at Monash Medical Centre (MMC) Clayton within easy walking distance of both Monash University Clayton Campus and the Clayton Shopping District.
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