Low cost interventions for prevention of chronic diseases
Dr Kirthi Menon is a doctoral research fellow and consultant endocrinologist and general physician based at Monash Health with outpatient clinical appointments in the Diabetes Service. The research project will focus on the potential of carnosine supplementation in reducing cardiometabolic risk in healthy overweight and obese individuals. Carnosine, is present in several tissues including muscle and brain, easily crosses the blood-brain barrier, and extensive animal data show that carnosine has chelating properties and modulates glucose metabolism, advanced glycation, pro-inflammatory and pro-oxidative states, as well as motor functions and neurotransmission.
The primary endpoint is insulin sensitivity measured using a euglycaemic glucose clamp at baseline and 16 weeks later. Secondary end-points measurement include inflammatory markers, advanced glycation and lipoxidation end products, arterial stiffness, central blood pressure and endothelial function, all of which are measured at baseline and then at week 16.