Chronic Disease, Diabetes and Metabolic Health

The Chronic Disease, Diabetes and Metabolic Health research theme is integrated with the National Association of Diabetes Centres accredited Centre of Excellence in diabetes research, education and clinical care, based across MCHRI and Monash Health. This theme includes work in gestational diabetes; epidemiology, prevention of GDM and adverse pregnancy outcomes, mechanisms underpinning GDM, risk prediction and surveillance, large scale NHMRC funded RCTs, optimal GDM management and models of care, surveillance and lifestyle intervention post GDM for prevention of type II diabetes (GACD funded), and diabetes (epidemiology, prevention with large scale RCTs, optimal treatment and models of care). Key priorities are international leadership on GDM linked to a WHO data repository and the establishment of a risk prediction and implementation of a national surveillance model for risks of GDM, adverse pregnancy outcomes and postpartum diabetes conversion.

Theme Lead

Associate Professor Barbora de Courten is a National Heart Foundation Future Leader Fellow and a general physician. Her research covers the full research continuum from basic science, epidemiology, clinical trials to clinical practice, public health and health economics. It involves discovery of disease biomarkers through uncovering mechanistic causal relationships in pathophysiology to testing innovative interventions for prevention and treatment of diabetes and related chronic diseases as well as developing new models of care.

Theme Research Areas

Biomarkers of Diabetes and Chronic Diseases

Overview of Activities

Investigating disease biomarkers including inflammation markers, advanced glycation end-products (AGEs), microbiome, lipidomics.

Our Team

  • Associate Professor Barbora de Courten
  • Dr Aya Mousa
  • Dr Negar Naderpoor
  • Dr David Scott
  • Estifanos Baye (student)

Key Collaborators

  • Jose Fernandez-Real, Biomedical Research Institute of Girona
  • Marloes Dekker Nitert, The University of Queensland
  • Peter Meikle, Baker IDI
  • Josephine Forbes, The University of Queensland
  • Prof Magdalena Plebanski, RMIT
  • Prof Susanne Bugel, University of Copenhagen, Denmark
  • Prof Lars Dragsted, University of Copenhagen, Denmark
  • Prof Reaven, Veterans Affair Hospital, USA

Major Current Projects

  • Inflammatory markers and adipokines in obesity, prediabetes, type 2 diabetes, and gestational diabetes
  • Role of AGEs in diabetes and cardiovascular diseases
  • Lipidomics in obesity, diabetes, cardiovascular disease, gestational diabetes and polycystic ovary syndrome
  • Microbiome in obesity, diabetes and cardiovascular disease

Low-Cost Interventions for Prevention and Treatment of Type 2 Diabetes and Related Chronic Diseases

Overview of Activities

Investigating role of diets, nutraceuticals and pharmaceuticals for prevention and treatment of diabetes and related chronic diseases.

Our Team

  • Associate Professor Barbora de Courten
  • Dr Aya Mousa
  • Dr Negar Naderpoor
  • Dr Kevin Lee
  • Mr Estifanos Baye (student)
  • Dr Kirthi Menon (student)

Key Collaborators

  • Associate Professor Ukropcova, Slovak Academy of Sciences, Bratislava
  • Professor Derave, University of Ghent, Belgium
  • Professor Aldini, University of Milan, Italy
  • Professor Bhatnagar, University of Louisville, USA
  • Professor Uribarri, Mount Sinai, USA
  • Professor Susanne Bugel, University of Copenhagen
  • Professor Lars Dragsted, University of Copenhagen
  • Professor Scragg, University of Auckland, New Zealand
  • Ms Shelley Gorman, Telethon Kids Institute, Perth
  • Ms Jemma Evans, Hudson Institute
  • Ms Josephine Forbes, The University of Queensland

Major Current Projects

  • AGEs – Diets low in advanced glycation end-products and prevention of type 2 diabetes and cardiovascular disease
  • Vitamin D – Vitamin D and prevention of type 2 diabetes and role of SNPs
  • Carnosine (A) – Carnosine supplementation and prevention of type 2 diabetes and cardiovascular risk factors
  • Carnosine (B)  – Carnosine supplementation and management of type 2 diabetes and cardiovascular risk factors
  • Metformin – Does Metfomin positively change microbiome in PCOS?
  • Nutrigenomics for personalised nutrition and prevention and treatment of chronic diseaseas

Models of Care for Diabetes

Overview of Activities

Evaluating models of care for treatment of diabetes and related chronic diseases.

Our Team

  • Dr Georgia Soldatos
  • Associate Professor Barbora de Courten
  • Professor Helena Teede
  • Dr Negar Naderpoor

Major Current Projects

  • Shared Medical Appointments
  • Cystic Fibrosis Diabetes Clinic
  • Diabetes support service

Gestational Diabetics, Diabetes and Chronic Disease Prevention

This program is integrated with the National Association of Diabetes Centres accredited Centre of Excellence, at Monash Health in diabetic research, education and clinical care.

Leads

Our Team

  • Dr Georgia Soldatos
  • Dr Kevin Lee
  • Dr Negar Naderpoor
  • Dr Aya Mousa

Key Collaborators

  • Professor David Simmons (NSW)
  • Shakila Thanaraginum (UK)
  • Including national Leads across 10 of the largest maternity centres nationally

Major Collaborations

  • International IWHP network

Major Current Projects

  • Gestational diabetics
  • Epidemiology
  • Prevention of GDM and adverse pregnancy outcomes
  • Mechanisms underpinning GDM, risk prediction and surveillance
  • Large scale NHMRC funded RCTs
  • Optimal GDM management and models of care, surveillance and lifestyle intervention post GDM for prevention of type II diabetes

Key priorities are establishment of a risk prediction tool and implementation of a national surveillance model for assessing risks of GDM.