Our outputs

Click the researcher names below to see their full lists of research publications.

Here is a selection of our most impactful publications over the last five years:

Effect of Atorvastatin on Knee Cartilage Volume in Patients With Symptomatic Knee Osteoarthritis: Results From a Randomized Placebo-Controlled Trial.
Wang Y, Jones G, Hill C, Wluka AE, Forbes AB, Tonkin A, Hussain SM, Ding C, Cicuttini FM. Arthritis Rheumatol. 2021 Nov;73(11):2035-2043. doi: 10.1002/art.41760. Epub 2021 Sep 27.

Study findings do not support the use of atorvastatin in the treatment of knee osteoarthritis. But widespread use of statins in the management of cardiovascular disease may have some benefit on reducing the progression of knee osteoarthritis.

Effect of Intra-articular Platelet-Rich Plasma vs Placebo Injection on Pain and Medial Tibial Cartilage Volume in Patients With Knee Osteoarthritis: The RESTORE Randomized Clinical Trial.
Bennell KL, Paterson KL, Metcalf BR, Duong V, Eyles J, Kasza J, Wang Y, Cicuttini F, Buchbinder R, Forbes A, Harris A, Yu SP, Connell D, Linklater J, Wang BH, Oo WM, Hunter DJ. JAMA. 2021 Nov 23;326(20):2021-2030. doi: 10.1001/jama.2021.19415.

Treatment with platelet-rich plasma did not significantly improve knee pain or slow disease progression in adults with mild to moderate knee osteoarthritis.

Effect of Vitamin D Supplementation on Tibial Cartilage Volume and Knee Pain Among Patients With Symptomatic Knee Osteoarthritis: A Randomized Clinical Trial.
Jin X, Jones G, Cicuttini F, Wluka A, Zhu Z, Han W, Antony B, Wang X, Winzenberg T, Blizzard L, Ding C. JAMA. 2016 Mar 8;315(10):1005-13. doi: 10.1001/jama.2016.1961.

Study changed practice: Vitamin D is no longer used for OA.

Efficacy of Low-Dose Amitriptyline for Chronic Low Back Pain: A Randomized Clinical Trial.
Urquhart DM, Wluka AE, van Tulder M, Heritier S, Forbes A, Fong C, Wang Y, Sim MR, Gibson SJ, Arnold C, Cicuttini FM. JAMA Intern Med. 2018 Nov 1;178(11):1474-1481. doi: 10.1001/jamainternmed.2018.4222.

Clinical trial that showed that low dose amitriptyline may be effective in back pain by reduced fear avoidance and increasing activity; potential for reduction in narcotic use and disability.

OP0015 Genomic risk score for advanced osteoarthritis in older adults
Lacaze P, Polekhina G, Bakshi A, Riaz M, Owen A, Franks A, Wang Y, Abidi J, Tiller J, Orchard S, McNeil J, Cicuttini F. Annals of the Rheumatic Diseases 2021;80:9.

Genomic risk scores have the potential to improve prevention of severe knee and hip osteoarthritis by providing a personalized approach and identifying individuals who may benefit from early intervention.

Effect of breakfast on weight and energy intake: systematic review and meta-analysis of randomised controlled trials.
Sievert K, Hussain SM, Page MJ, Wang Y, Hughes HJ, Malek M, Cicuttini FM. BMJ. 2019 Jan 30;364:l42. doi: 10.1136/bmj.l42.

BMJ editor’s pick. Evidence that challenges the dogma that breakfast is important for preventing obesity. The Altmetric top 100 globally (as the 50th most tracked scientific report globally of any field in 2019 of 2.7 million papers).

Tackling obesity in knee osteoarthritis.
Wluka AE, Lombard CB, Cicuttini FM. Nat Rev Rheumatol. 2013 Apr;9(4):225-35. doi: 10.1038/nrrheum.2012.224. Epub 2012 Dec 18.

Invited review summarising the effects of obesity on joints in OA, via  metabolic and loading factors.

Weight change and change in tibial cartilage volume and symptoms in obese adults.
Teichtahl AJ, Wluka AE, Tanamas SK, Wang Y, Strauss BJ, Proietto J, Dixon JB, Jones G, Forbes A, Cicuttini FM. Ann Rheum Dis. 2015 Jun;74(6):1024-9. doi: 10.1136/annrheumdis-2013-204488. Epub 2014 Feb 11.

This study showed that even minor weight loss or gain has a very significant effect on pain and damage to knee structure.

Female Reproductive and Hormonal Factors and Incidence of Primary Total Knee Arthroplasty Due to Osteoarthritis.
Hussain SM, Wang Y, Giles GG, Graves S, Wluka AE, Cicuttini FM. Arthritis Rheumatol. 2018 Jul;70(7):1022-1029. doi: 10.1002/art.40483. Epub 2018 May 14.

Reproductive and hormonal factors are associated with risk of knee OA. However, the effect of these factors in the associations are complex and further work is needed to understand the complex effect of these factors on knee OA.

Systematic review and meta-analysis of the prevalence of neuropathic-like pain and/or pain sensitization in people with knee and hip osteoarthritis.
Zolio L, Lim KY, McKenzie JE, Yan MK, Estee M, Hussain SM, Cicuttini F, Wluka A. Osteoarthritis Cartilage. 2021 Aug;29(8):1096-1116. doi: 10.1016/j.joca.2021.03.021. Epub 2021 May 8.

Although knee pain in osteoarthritis can originate from the joint, this study shows that 20-24% of people have pain that relates to changes in nervous system. Replacing the knee joint may not result in pain reduction in these people, as the severity of pain may not relate to the osteoarthritic changes in the joint.