Associate Professor Andreas Fouras
NHMRC Career Development Fellow
Mechanical and Areospace Engineering
Andreas Fouras is an Associate Professor of Mechanical and Aerospace Engineering and an NHMRC Career Development Fellow. He leads the Laboratory for Dynamic Imaging at Monash University. Andreas’s research focuses on developing new imaging technology and applying this technology to the benefit of medical science and clinical practice. His keen interest in mechanobiology - the study of physical forces in biomedical processes - has led to developments of new imaging technology that unlock this knowledge. He has developed extensive expertise in the in vivo measurement of motion and flow utilising a range of modalities spanning the visible to X-ray spectra. Andreas has founded a startup company 4Dx Pty Ltd to ensure maximum impact of that technology.
Andreas' efforts focus in the field of mechanobiology – the way that physical forces and changes in cell or tissue mechanics contribute to development, physiology, and disease. In particular, his efforts in research and supervision have led to the development and subsequent application of new imaging technology for the measurement of physically dynamic events within biomedical systems. Over recent years, he has made significant advances in a number of fields:
- X-ray computed tomographic (CT) velocimetry techniques. Recently, Andreas has successfully translated this patented technology from the synchrotron to the laboratory. This development is embodied in the globally unique pre-clinical real-time functional CT system in operation in his laboratory. This technology is well placed to have a dramatic impact in research into the lung, diseases of the lung and their treatment. Progress in being made into the further development of this technology to a human platform where this technology is set to make a huge impact into the clinical treatment of all diseases of the lung – currently responsible for approximately 1/6th of all healthcare. Andreas is currently leading efforts to develop a clinical trial for evaluation of the utility of this technology for lung cancer screening with researchers at Cambridge, clinicians at the nearby Papworth. Work is underway to extend the application of this technology to include the heart.
- Non-contact cell rheology microfluidics technology. This patented technology has great potential as a research tool across a variety of fields of study from: early stage embryo development; to the effects of the malaria parasite on the rheology of red blood cells; to the study of the mechanical forces that lead to the triggering of pathological activation of platelet cells – a key event in the pathway towards heart attack and stroke.
- Multimodal image processing platform. This powerful suite of techniques is proving to be a game changer across a wide range of research applications. The most striking example of the power of this flexible tool is the key role this technology has had in the discovery of the dominant role played by mechanical forces in the determination of cell fate within the early mammalian embryo.
Recent relevant publications
- DUBSKY, S., HOOPER, S.B., SIU, K.K.W. & FOURAS, A. (2012) Synchrotron-based dynamic computed tomography of tissue motion for regional lung function measurement, Journal of the Royal Society Interface. Published online first, doi: 10.1098/rsif.2012.0116
- CURTIS, M.D., SHEARD, G.J. & FOURAS, A. (2011) Feedback control system simulator for the control of biological cells in microfluidic cross slots and integrated microfluidic systems. Lab on a Chip, 11(14), 2343–2351
- NESBITT, W.S., WESTEIN, E., LOPEZ, F.J.T., TOLOUEI, E., MITCHELL, A., FU, J., CARBERRY, J., FOURAS, A. & JACKSON, S.P. (2009) A shear gradient-dependent platelet aggregation mechanism drives thrombus formation, Nature Medicine, 15, 665-673
Dynamic Imaging, X-ray Imaging, Animal models, Respiratory, Cardiovascular, Pulmonary, Imaging, Microfluidics, Diagnostic, Lung, Biomechanics, Mechanobiology