Genetics of Neurodevelopmental disorders

Neurodevelopmental disorders, such as autism spectrum disorders (ASDs) and attention deficit hyperactivity disorder (ADHD) are highly heritable disorders with negative lifetime outcomes.

The Bellgrove Laboratory at MICCN is engaged in gene discovery for neurodevelopmental disorders using a range of methodologies including candidate gene, genome wide association and DNA sequencing.

Since disorders such as ADHD and ASD present as complex, heterogeneous and often overlapping phenotypes, our laboratory has a particular focus in using objective measures of cognitive and brain function alongside detailed behavioural assessments to identify relatively homogeneous subtypes.

It is hoped that the identification of biologically grounded subtypes may facilitate gene discovery in complex neurodevelopmental disorders.

Capability Lead

Prof Mark Bellgrove

E: Mark.Bellgrove@monash.edu

Professor Bellgrove is an NHMRC Senior Research Fellow and Director of Research at MICCN, where he leads a group of MICCN scientists who use a multidisciplinary approach to address fundamental questions regarding the biology of human cognition. Members of his laboratory have skills in cognitive neuroscience, psychopharmacology, molecular biology and molecular and statistical genetics.