Computational neurodegeneration: From proteins to phenotypes through dysconnection

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Event Details

9 August 2018 at 12:30 pm – 9 August 2018 at 1:30 pm
Monash Biomedical Imaging Auditorium, 770 Blackburn Road
Open to:
Engineering; Information Technology; Medicine, Nursing, Health Science; Science; Seminars & Workshops



Successful treatment and ultimately prevention of dementia will depend on early, reliable disease detection and discrimination of the diverse disease processes that cause neurodegeneration. Currently, magnetic resonance imaging (MRI) methods cannot capture how brain regions work together or the effects of disease on specific nerve cell types that are essential to the disease process and are potential targets of rational treatment.

In this seminar, Dr Adeel Razi will demonstrate new tools and technologies and show recent empirical work using functional MRI in patient cohorts with well-defined dementias representing distinctive brain pathologies. The methods proposed will uncover the mechanisms whereby pathological proteins selectively target particular brain regions and nerve cell types, and allow measurement of protein effects over the whole brain. The tools and neuronal markers of disease progression may lead to improved dementia diagnosis and therapy trials.


Dr Adeel Razi is a Senior Research Fellow, ARC DECRA Fellow and Principal Investigator of recently established Computational and Systems Neuroscience Laboratory at the Monash Institute of Cognitive & Clinical Neuroscience and Monash Biomedical Imaging. He is an Honorary Senior Research Associate at the Wellcome Centre for Human Neuroimaging of University College London where he also worked from 2012 to 2018.

Dr Razi develops data science techniques for brain mapping in health and disease. His research interests are in modelling complex, high dimensional, network dynamics of brain structure and function using neuroimaging. He uses these models to integrate empirical data, measured using functional and diffusion MRI, to investigate basic disease mechanisms in neurodegenerative diseases

Monash Biomedical Imaging
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Monash Biomedical Imaging