How to repair your gut

In a world first, Monash University researchers have identified a key biomolecule that enhances the repair of your gut lining by prompting stem cells to regenerate damaged tissue.

A strong cellular lining is essential for a healthy gut as it provides a barrier to the billions of microbes and harmful toxins present in our intestinal tract. This barrier is often damaged by infection and inflammation, which causes many painful symptoms.

The study, published in Cell Stem Cell and led by Professor Helen Abud and Dr Thierry Jardé from Monash Biomedicine Discovery Institute, investigated the environment that surrounds gut stem cells and used “mini gut” organoid methodology where tiny replicas of gut tissue were grown in a dish.  The study defined key cells that reside in close proximity to stem cells in the gut that produce the biomolecule Neuregulin-1 that acts directly on stem cells to kick-start the repair process.

Read the full story here.