Monash University scientists uncover pivotal virus structure

Researchers from the Monash Biomedicine Discovery Institute (BDI) have revealed the structure of a protein complex that is essential for the poliovirus to replicate. The structure may be similar to those in other RNA viruses and form a potential target for the development of antiviral drugs halting virus replication more broadly.

Scientists in Professor Jackie Wilce and Professor Matthew Wilce’s laboratory used poliovirus – representative of the picornavirus family of viruses that includes the virus causing the common cold – as their virus of focus.

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