Memorial Sloan Kettering Cancer Center
Lorenz Studer runs one of the world’s leading laboratories in stem cell biology, addressing basic science, disease modeling and clinical applications, with a focus on the human brain and brain diseases.
Directing Fate and Age of Human Pluripotent Stem Cells
- Deriving specific brain and spinal cord cell types from human PSCs (including midbrain dopaminergic, and cortical subtypes of neurons)
- Directing neural crest and sensory placode lineages (e.g. sensory and trigeminal neurons)
- Rapid induction of fate, maturation, and age in human PSC-derived lineages
- Modeling Human Disease Using Pluripotent Stem Cells
- Modeling familial dysautonomia and other NC-related disorders
- Modeling herpes simplex encephalitis and neurodevelopmental disorders
- Modeling Parkinson’s disease and other age-related disorders
Human Pluripotent Stem Cells in Cell Therapy
The Studer lab has resolved some of the major challenges in generating the correct nerve cell type for cell therapy of Parkinson’s Disease at sufficient scale and purity. The lab is pursuing the development of a clinical-grade dopamine neuron cell product and are in the process of generating the data necessary for an IND (investigational new drug) application from the FDA.