Better drugs for heart attacks

A certain GPCR has been identified to be an important target to better treat myocardial ischaemic reperfusion injury (IRI). We have identified some small molecule agonists of this GPCR as potential IRI treatments. The aim of this medicinal chemistry project is to find out how to make these molecules more potent, more selective, more soluble and metabolically stable, suitable to be a therapeutic intervention.

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