Design and evaluation of gene delivery systems
Delivery of nucleic acids (DNA, mRNA or siRNA) for ‘gene therapy’ presents a formidable challenge to pharmaceutical scientists. These molecules are large, anionic entities that are essentially unable to diffuse through lipid bilayers. This restricts their access to tissues by passive diffusion and implies that delivery systems need to be carefully designed and need to include strategies to overcome a series of biological barriers. Projects are available to assist in the design and development of both viral and non-viral gene delivery systems, predominantly aimed at treatment of cancer.