Enhancing bioavailability of poorly water-soluble drugs from the gastrointestinal tract
Successful oral delivery of poorly water-soluble drugs (PWSD) is a common challenge to pharmaceutical formulators. The most promising solutions involve presenting the drug in an amorphous form, either as a lipid-based formulation or as an amorphous dispersion of drug in a polymer carrier. In both cases the challenge is to avoid precipitation of drug as the formulation encounters the changing environment during its transit through the gastrointestinal tract. Precipitation can occur on dispersion or on digestion of lipid components of the delivery system. A number of strategies have been devised by the Monash Institute Pharmaceutical Science research group and we have established in vitro tests to help formulators predict the fate of drugs in the gastrointestinal tract. Projects are available to further evaluate lipid delivery systems, using in vitro testing procedures.