Restoring blood-brain barrier homeostasis for the treatment of Alzheimer’s disease

The blood-brain barrier exhibits various biochemical changes during Alzheimer’s disease that lead to impaired removal of toxins from the brain or impaired brain uptake of nutrients essential for cognition. Our research has identified that the levels of certain blood-brain barrier transporters and carrier proteins are reduced in Alzheimer’s disease and restoring their levels may open up novel therapeutic opportunities for Alzheimer’s disease. Using a host of in vitro and in vivo approaches, this project will identify novel approaches to reverse these biochemical changes, ultimately leading to improved cognitive function in Alzheimer’s disease.

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