Lipidated polymers for inhibiting the precipitation of poorly water soluble drugs
Strategies for inducing supersaturation of poorly water soluble drugs (and thereby enhancing drug absorption and bioavailability) are becoming increasingly important due to the development of new drug molecules with poor solubility profiles. To address this issue, lipid-based formulations (LBFs) have been employed to good effect to prolong supersaturation, although rapid precipitation during digestion still plagues certain molecules.
One strategy for increasing the duration of supersaturation afforded by LBFs is to include a small amount of polymer in the formulation. The extent to which a homogeneous LBF incorporating a polymer can be prepared will be dictated by the particular lipids used and the polymer structure. This project will explore the potential of a novel class of lipidated polymers as precipitation-inhibiting additives in lipid based formulations, and examine the extent to which these materials increase the concentration of a model drug during digestion.
The student will gain skills in advanced polymerization techniques, basic synthetic organic chemistry and pharmaceutical formulation testing.