Epigenetics - a new vista for medicinal chemistry and chemical biology
Epigenetics describes the management of the genetic code to influence protein expression in cells and organisms. It is a major driver of cellular transformation in cancer and many other diseases. We are developing novel inhibitors of epigenetic regulators, utilizing structure-based drug design principles, stereoselective synthesis, with biochemical and cell based assays.
1. epigenetic drug discovery - fragment based design of bromodomain inhibitors
2. dolid phase synthesis of chromodomain epigenetic reader proteinsand peptidomimetic inhibitors.
3. combination kinase and bromodomain inhibitors - knocking down Myc in cancer