PROTACs for the treatment of cancers

More recently, there has been an increasing interest in the degradation of proteins as a means to down-regulate disease related protein function. Proteolysis-targeting chimeric molecules (PROTACs) are an emerging technique for targeted protein degradation. Although, this technology is getting much attention due to its potential for therapeutic intervention, it is still at its infancy stage and much remains to be learned, particularly regarding its potential for GPCR pharmacology. Here, we will focus on the development of novel PROTACs targeting therapeutically relevant proteins for the treatment of cancers.