Small molecule inhibitors of MAP4K4 as a potential therapy for the treatment of Motor Neurone Disease (MND)

Motor Neurone Disease (MND) is a condition involving the progressive degeneration of nerve cells in muscles, degrading the ability of skeletal muscle control while inevitably leading to death within 3-5 years of onset. No known cure is known to date with current treatments being insufficient. Recent studies have identified a new enzyme target, MAP4K4, linking the protein to the disease state as a therapeutic target. We aim to screen and develop novel hit small-molecule inhibitors of MAP4K4 to explore their potential as a therapy for MND.