Labs

Lab head

Lab name

Research areas

Professor Patrick Sexton

Metabolic G protein-coupled receptor group

metabolic and endocrine disorders, neuropsychiatric disease, allosteric modulation, biased agonism, structural biology, chemical biology, integrated pharmacology, receptor trafficking, compartmentalised signaling

Professor Arthur Christopoulos

G protein-coupled receptor allosteric modulation and drug targeting

neuropsychiatric diseases, metabolic and endocrine disorders, cardiovascular disease, allosteric modulation, drug discovery, chemical biology, schizophrenia, Alzheimer’s disease, structural biology, biased agonism

Dr Meritxell Canals

GPCR trafficking and regulatory complexes

pain, inflammation, neuropeptide receptors, protein trafficking and regulation, signal transduction

Dr Betty Exintaris

Tissue electrophysiology

Prostate, benign prostatic hyperplasia (BPH), lower urinary tract symptoms, smooth muscle, spontaneous activity, contractile activity, slow waves, metabolic and endocrine disorders, inflammation.

Dr Sebastian Furness
Metabolic G protein-coupled receptor group
cass B GPCRs, mechanisms of efficacy, molecular effector coupling, biased agonism, chemical biology, signal transduction, structural biology, integrated pharmacology, metabolic and endocrine disorders, diabetes, cancer

Dr Karen Gregory

Class C G protein-coupled receptor biology

neuropsychiatric diseases, schizophrenia, alzheimer's disease, allosteric modulation, neuronal culture, cell signalling, chemical biology, structural biology, dimerization, mutagenesis

Dr Michelle L Halls

GPCR signalosomes and compartmentalization

protein complexes, signal compartmentalisation, spatiotemporal signalling, cAMP, ERK, receptor trafficking, cancer

Dr John Haynes

Stem cell biology laboratory

Parkinson's disease, neuroinflammation, neurodegeneration, neuropsychiatric disease, neurodevelopment, Renal disease, Alport Syndrome, cardiovascular disease

Dr Dana Hutchinson

Metabolic G protein-coupled receptor group

adipocytes, cardiomyocytes, cellular metabolism, GPCRs, skeletal muscle, metabolic and endocrine disorders, glucose uptake, cellular respiration

Associate Professor Helen Irving

Hidden regulatory centres

inflammation, immune system, moonlighting catalytic centres, serotonin receptors, chemical biology, gastrointestinal health, haplotypes

Dr Rob Lane

Dopamine receptor pharmacology

Neuropsychiatric disease, Parkinson’s disease, schizophrenia, allosteric modulation, biased agonism

Dr Chris Langmead

Servier program in drug discovery - molecular and translational drug discovery

neuropsychiatric disease, inflammation, metabolic and endocrine disorders, drug discovery, orphan G protein-coupled receptors, high-throughout screening, hits-to-leads, translational biology, high content imaging, biased agonism

Dr Katie Leach

Class C G protein-coupled receptor biology

calcium sensing receptor, cell signalling, allosteric modulators, receptor structure-function, drug-receptor interactions, analytical/molecular pharmacology, biased agonism/ modulation, metabolic and endocrine disorders.

Dr Lauren May

Cardiac G protein-coupled receptor pharmacology

cardiovascular disease, heart failure, ischaemia-reperfusion injury, G protein-coupled receptors, adenosine receptors, allosteric modulation, biased agonism, structural biology, molecular modelling, ligand-receptor interactions

Dr Daniel Poole

Enteric neurobiology and digestive disease

Inflammation, Colitis, Neuroscience, Enteric Nervous System, Pain, Neuroimmune Interaction, Gastrointestinal Physiology, Glia, TRP Channels

Dr Erica Sloan

Neural regulation of cancer

cancer, stress, symptoms, treatment, metastasis, molecular and cellular mechanisms, imaging, behaviour, mouse models.

Dr Celine Valant

Muscarinic receptors group

Neuropsychiatric disorders, asthma/COPD, endogenous and synthetic allosteric modulators, GPCRs

Dr Sab Ventura

Male reproductive pharmacology

male contraception, benign prostatic hyperplasia, prostate cancer, vas deferens, adrenoceptors, purinoceptors.

Dr Paul White

Cardiac G protein-coupled receptor pharmacology

cardiovascular disease, heart failure, ischaemia-reperfusion injury, G protein-coupled receptors, adenosine receptors, allosteric modulation, biased agonism, structural biology, molecular modelling, ligand-receptor interactions

Dr Denise Wootten

Metabolic G protein-coupled receptor group

Class B GPCRs, biased agonism, allosteric modulation, structural biology, chemical biology, receptor trafficking, signal transduction, integrated pharmacology, metabolic and endocrine disorders, diabetes.