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Dr Miles De Blasio

Research Fellow

BSc(Hons) | PhD, University of Adelaide

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Contact   miles.deblasio@monash.edu

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Miles De Blasio is a Senior Researcher in the Heart Failure Pharmacology laboratory at Monash Institute of Pharmaceutical Sciences. He is also an Honorary Research Fellow of the Department of Pharmacology, Monash University and an Honorary Baker Heart and Diabetes Institute Researcher.

He completed his PhD in 2004 (University of Adelaide) where he studied the endocrine and metabolic basis of postnatal growth, diabetes and obesity in various organ systems. After a 4-year period in industry with the Australian Pork Cooperative Research Centre (Pork CRC) he moved to the University of Cambridge (United Kingdom) to undertake a two very successful post-doctoral research projects investigating the role of leptin administration in the development of the fetal sheep lung and heart and the role of glucocorticoids and thyroid hormones in fetal development. In 2014, he returned to Australia and was recruited by Prof Rebecca Ritchie to investigate new treatments for diabetic cardiomyopathy at the Baker Heart and Diabetes Institute. In 2020 he moved to Monash Institute of Pharmaceutical Sciences.

His current research is focused on determining the mechanisms involved in providing cardioprotection in patients with diabetes-induced left ventricular diastolic dysfunction. This includes the use of pharmacological agents and cardiac-selective gene therapies to target cardioprotective pathways involved in regulation of the Hexosamine-Biosynthesis Pathway (HBP) and O-GlcNAcylation of proteins involved in cardiac function. He also investigates the involvement of the adiponectin pathway in diabetic cardiomyopathy. Outcomes of his research are essential for diabetic patients to help find a specific treatment for diabetic cardiomyopathy, for which there is currently no cure.

Dr De Blasio has over 50 publications in high impact factor journals in various research fields including fetal programming, diabetes and cardiovascular physiology. He has attracted research funding from NHMRC, Diabetes Australia, CASS Foundation, Pork CRC and Channel 7 Children’s Research Foundation. He has supervised more than 20 undergraduate, Honours and PhD students.

Awards

  • Bright Sparks Travel Award, Baker Heart and Diabetes Institute (2016)
  • Baker Heart and Diabetes Institute Research Prize (2015)
  • Trust for Research and Education in the Biology of Reproduction (TREBR) International Travel Award (2013)
  • Avrith International Travel Award, University of Cambridge (2012)

Achievements

  • Associate Editor, Frontiers in Physiology, Integrative Physiology
  • Review Editor, Frontiers in Pharmacology, Translational Pharmacology
  • Guest Associate Editor, Clinical and Translational Physiology
  • State Representative (Victoria), Cardiovascular Special Interest Group (CVSIG)

Publication highlights

DE BLASIO MJ*, Lanham SA*, Blache D, Oreffo ROC, Fowden AL, Forhead AJ. (2018). Sex- and bone-specific responses in bone structure to exogenous leptin and leptin receptor antagonism in the ovine fetus. American Journal of Physiology - Regulatory, Integrative and Comparative Physiology – Special Issue: Model Systems for the Study of Integrative Physiology: The Rebirth of Translational Biology 314(6): R781-R790. *Equal first authors.

Spallotta F, Cencioni C, Atlante S, Garella D, Cocco M, Mori M, Mastrocola R, Kuenne C, Guenther S, Nanni S, Azzimato V, Zukunft S, Kornberger A, Sürüm D, Schnütgen F, von Melchner H, Di Stilo A, Aragno M, DE BLASIO MJ, Ritchie RH, Zaccagnini G, Martelli F, Farsetti A, Fleming I, Braun T, Beiras-Fernandez A, Botta B, Collino M, Bertinaria M, Zeiher AM, Gaetano C. (2018). Stable oxidative cytosine modifications accumulate in cardiac mesenchymal cells from Type2 diabetes patients: rescue by alpha-ketoglutarate and TET-TDG functional reactivation. Circulation Research122(2): 31-46.

DE BLASIO MJ*, Ramalingam A*, Cao A, Prakoso D, Ye J, Pickering R, Watson AMD, de Haan JB, Kaye DM, Ritchie RH. (2017). The superoxide dismutase mimetic tempol blunts diabetes-induced upregulation of NADPH oxidase and endoplasmic reticulum stress in a rat model of diabetic nephropathy. European Journal of Pharmacology 807: 12-20.*Equal first authors.

Prakoso D*, DE BLASIO MJ*, Rosli S, Qin C, Kiriazis H, Du X-J, Gregorevic P, McMullen JR, Ritchie RH. (2017). Phosphoinositide 3-Kinase (p110α) Gene Delivery Prevents the Progression of Diabetic Cardiomyopathy in a Mouse Model of Diabetes with Established Diastolic Dysfunction. Clinical Science (London) 131(12): 1345-1360. *Equal first authors.

Qin CX, Finlayson SB, AI-Sharea A, Rosli S, Prakoso D, DE BLASIO MJ, Thomas CJ, Yang YH, Morand EF, Perretti M, Murphy A, Du X-J, Gao X-M, Ritchie RH. (2017). Endogenous Annexin-A1 regulates haematopoietic stem cell mobilization post myocardial infarction in mice in vivo. Scientific Reports 7(1):16615.

DE BLASIO MJ, Kempster SL, Smith GCS, Charnock-Jones DS, Denyer A, Hughes A, Wooding FPB, Blache D, Fowden AL, Forhead AJ (2016). Leptin matures aspects of lung structure and function in the ovine fetus. Endocrinology 157(1): 395–404.

Vaughan OR, Davies KL, Ward JW, DE BLASIO MJ, Fowden AL (2016). A physiological increase in maternal cortisol alters uteroplacental metabolism in the pregnant ewe. Journal of Physiology. 594(21): 6407-6418.

DE BLASIO MJ, Boije M, Bernstein BS, Davies KL, Plein A, Kempster SL, Smith GCS, Charnock-Jones DS, Blache D, Wooding FPB, Giussani DA, Fowden AL, Forhead AJ (2015). Developmental expression and glucocorticoid control of the leptin receptor in fetal ovine lung. PLoS One 10(8): e0136115.

DE BLASIO MJ, Huynh K, Qin C, Rosli S, Kiriazis H, Du X-J, McMullen JR, Ritchie RH. (2015). Therapeutic Targeting of Oxidative Stress with Coenzyme Q10 Counteracts Exaggerated Diabetic Cardiomyopathy in a Mouse Model of Diabetes with Diminished PI3K(p110α) Signalling. Free Radical Biology and Medicine 87(12407): 137-147.

DE BLASIO MJ, Gatford KL, McMillen IC, Robinson JS, Owens JA (2007). Placental restriction of fetal growth increases insulin action, growth and adiposity in the young lamb. Endocrinology 148(3): 1350-1358.

DE BLASIO MJ, Gatford KL, Robinson JS, Owens JA (2007). Placental restriction of fetal growth reduces size at birth and increases postnatal growth and adiposity in the young lamb. American Journal of Physiology Regulatory, Integrative and Comparative Physiology 292(2): R875-R886. [IF: 3.284].

DE BLASIO MJ, Dodic M, Moritz K, Wintour-Coghlan EM, Robinson JS, Owens JA (2007). Maternal exposure to cortisol in early pregnancy causes fasting hyperglycaemia and hyperinsulinaemia in adult male sheep offspring. American Journal of Physiology Endocrinology and Metabolism 293(1): E75-E82.