Dr Karen Gregory
Rational discovery of new therapeutics relies on having a good understanding of the mechanism of action of a drug and how this relates to its effectiveness.
Dr Gregory is an early career researcher (PhD, 2009) with a strong expertise in the pharmacology of G protein-coupled receptors (GPCRs) and an international profile in the study of GPCR allosteric modulation and stimulus-bias. Dr Gregory returned to Australia in August 2013 to join the Drug Discovery Biology theme at Monash Institute of Pharmaceutical Sciences, where she is building her research team. Her research focuses on metabotropic glutamate receptor 5, a promising drug target for the treatment of a variety of CNS disorders including schizophrenia, depression, autism and Alzheimer's disease. She has authored 17 original research papers and is currently an NHMRC CJ Martin Biomedical Research fellow.
Selected recent publications
Wu H, Wang C, Gregory KJ, Han GW, Cho HP, Xia Y, Niswender CM, Katrich V, Meiler J, Cherezov V, Conn PJ, Stevens RC. Structure of a class C GPCR metabotropic glutamate receptor 1 bound to an allosteric modulator. Science. 2014;344(6179): 58-64.
Gregory KJ*, Herman EJ*, Ramsey AJ, Hammond AS, Byun NE, Stauffer SR, Manka JT, Jadhav S, Weaver CD, Niswender CM, Steckler T, Drinkenburg WH, Ahnaou A, Lavreysen H, Macdonald GJ, Bartolome JM, Mackie C, Hrupka BJ, Caron MG, Daigle TL, Lindsley CW, Conn PJ Jones CK. N-aryl piperazine metabotropic glutamate receptor 5 positive allosteric modulators possess efficacy in pre-clinical models of NMDA hypofunction and cognitive enhancement J. Pharm. Exp. Ther. 2013; 347(2):438-57.
Gregory KJ, Nguyen ED, Reiff SD, Squire EF, Stauffer SR, Lindsley CW, Meiler J, Conn PJ. Probing the Metabotropic Glutamate Receptor 5 (mGlu5) Positive Allosteric Modulator (PAM) Binding Pocket: Discovery of Point Mutations That Engender a "Molecular Switch" in PAM Pharmacology. Mol. Pharmacol. 2013;83(5):991-1006.
Gregory KJ, Noetzel MJ, Rook JM, Vinson PJ, Stauffer SR, Rodriguez AL, Emmitte KA, Zhou Y, Chun AC, Felts AS, Chauder BA, Lindsley CW, Niswender CM, Conn PJ. Investigating mGlu5 allosteric modulator cooperativity, affinity and agonism: enriching structure-function studies and structure-activity relationships. Mol Pharmacol. 2012;82(5):860-75.
Gregory KJ, Sexton PM, Tobin AB, Christopoulos A. Stimulus bias provides evidence for conformational constraints in the structure of a G protein-coupled receptor. J Biol Chem. 2012;287(44):37066-77.