Inflammation and pain are conserved protective mechanisms that are essential for survival. Inflammation, characterised by acute changes in the circulatory and immune systems, protects against infection. Pain allows avoidance of damaging stimuli.
Dysregulated chronic inflammation underlies diseases of global relevance — such as cardiovascular disease, cancer, diabetes, obesity and autoimmune diseases — and can cause chronic pain. Chronic inflammation and pain are major causes of human suffering, yet are poorly understood.
Research at DDB seeks to understand the basic mechanisms that control signalling of inflammation and pain, and determine whether defects in these regulatory mechanisms cause disease.