Dr Gong Chen
Gong Chen is a Research Officer with the Biopharmaceutics Section of the Centre for Drug Candidate Optimisation (CDCO). He completed his undergraduate degree in Pharmacology at Shanghai Medical University, China and his Ph.D. in Biopharmaceutical Science at University of Otago, New Zealand. Gong served as a postdoctoral fellow at the Monash Institute of Pharmacy (MIPS) before joining the CDCO in 2011. He specializes in the areas of preclinical pharmacokinetics and ADME lead optimization. Gong's role involves performing in vitro and in vivo ADME studies for preclinical drug candidates. He is passionate about his work and considers completing his doctoral studies and working within MIPS as his major achievements. Gong looks forward to expanding his expertise in biopharmaceutical science. Outside of work Gong loves to spend time with his wife and two children.
M Keenan, PW Alexander, JH Chaplin, MJ Abbott, H Diao, Z Wang, WM Best, C Perez, S Cornwall, S Keatley, RA Thompson, SA Charman, KL White, E Ryan, G Chen, TW von Geldern, E Chatelain. Evaluation of hits for T. cruzi inhibition identified in a high-throughput screen. Future Med Chem, 5:1733-1752, 2013.
Chen, G., Yang, L., Zhang, H., Tucker, I. G., Fawcett, J.P., Effect of ketocholate derivatives on methotrexate uptake in Caco-2 cell monolayers, International Journal of Pharmaceutics 43: 89– 93,2012
Yousef, J., Chen, G., Hill, P., Nation, R., Li, J., Melatonin attenuates colistin-induced nephrotoxicity in rats, Antimicrobial Agents and Chemotherapy, 55(9): 4044-4049, 2011
Chen, G., Fawcett, J.P., Mikov, M., Tucker, I.G. Monoketocholate can decrease transcellular permeation of methotrexate across Caco-2 cell monolayers and reduce its intestinal absorption in rat. Journal of Pharmacy and Pharmacology 61: 953-959, 2009
Chen, G., Fawcett, J.P., Mikov, M., Tucker, I.G. 2009, Simultaneous determination of methotrexate and its polyglutamate metabolites in Caco-2 cells by liquid chromatography-tandem mass spectrometry. Journal of Pharmaceutical and Biomedical Analysis 50: 262-266.