Permeability across biological membranes is a key factor in the absorption and distribution of drugs. Poor permeability can arise due to a number of structural features, as well as membrane-based efflux mechanisms. This can lead to poor absorption across the gastrointestinal mucosa or poor distribution throughout the body.
CDCO offers in vitrocell-based methods to simulate gastrointestinal permeability and transporter interactions, and in vivo models to assess brain uptake.
Research platforms include:
- in silico predictive methods
- Caco-2 and MDCK cell culture models
- PAMPA (parallel artificial membrane permeability assay)
- in vivo brain-to-plasma ratio determination (rat/mouse)
- brain binding assays (rat/mouse)