The CDCO was established in 2003 through joint funding from the State Government of Victoria and Monash University, via the Science, Technology and Innovation Infrastructure (STII) Grants program. Since that time, we have received infrastructure support from the Monash Technology Research Platform network and NCRIS infrastructure support via Therapeutic Innovation Australia (TIA).
The CDCO is located within the Melbourne Biomedical Precinct at the Monash Institute of Pharmaceutical Sciences in Parkville, where we occupy approximately 700 m2 of custom designed laboratories and office space.
We are equipped with state-of-the-art infrastructure including:
- Eight LC/MS instruments coupled with UPLC (triple quadrupole MS and time of flight MS)
- Automated small animal in vivo blood sampling using BASi Culex™
- Automated in vitro assays using a Hamilton MICROLAB® STAR liquid handling robot
- In silico and in vitro methods for profiling physicochemical properties
- Plate based assays for CYP450 metabolic stability, metabolite profiling and metabolic drug interactions
- Cell culture facilities for permeability assessment (Caco-2 or MDCK)
Data and reports are securely archived using an IDBS electronic lab notebook.