Point-of-care nano-biosensors

The goal of this interdisciplinary research program is to develop novel photonic, electrochemical and mass spectrometry based biosensors made from porous silicon nano-architectures that are able to detect disease markers, infection, water-borne contaminants or illicit drugs at ultralow concentrations directly in complex matrices such as body fluids. Our particular targets are markers of cancer and cardiovascular disease, viral contamination and drugs of abuse. Our studies involve the design and testing of point-of-care sensor systems, the validation of their performance using benchmark assays and finally their clinical testing. Porous silicon nano-architectures are generated using electrochemical etching or metal-assisted chemical etching and these architectures are then surface-engineered for low fouling and high sensitivity target recognition.

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