Rational design of chiral catalysts for asymmetric synthesis
Access to multi-stereocentre containing (sp3-rich) scaffolds is essential to improving outcomes in drug discovery, particularly in phenotypic-based approaches. This program focusses on combining modular chiral catalyst design and advanced theoretic methods to remove barriers to the synthetic preparation of sp3-rich compounds, including bioactive natural products with therapeutic potential.
Enhanced research experiences
This program involves a collaboration with the Dr Elizabeth Krenske, ARC Future Fellow, University of Queensland (UQ). The student will work collaboratively with this group to improve catalyst design. The Krenske group undertake quantum mechanical studies (using density functional theory) of our chiral catalysts to help rationalise methods of chiral induction.
This option may be available. Contact Associate Professor Bernard Flynn for more details.
Depending on student interest, there exists an opportunity to spend a greater period of time with the Krenske group at UQ learning quantum mechanical methods (eg density functional theory).