SPATIAL ORGANISATION
OF SIGNALLING

Dynamic GPCR signalling localised to the nucleus (left) or plasma membrane (right) of single live cells.

Cells sense the environment and receive messages through large numbers of protein receptors expressed on the cell surface. Receptors and the signals they generate therefore control all aspects of life, from early development and neuronal activity, to the progression of diseases including cancer and CNS disorders. By developing and using new interdisciplinary techniques to visualise and map signals inside cells, we aim to understand how the signals receptors generate control a diverse variety of cell responses. By using this knowledge to develop drugs that target only disease relevant signals, we aim to increase the effectiveness of medicines and decrease their side effects.