Some Recent Publications

Haynes, J.M., Sibuea, S., Aguiar, A.A., Ho, J.K. & Pouton, C.W. (2021). Blocking b-catenin-dependent WNT signalling late in maturation elevates NR0B1/NR0B2 to reduce markers of a dopaminergic neuronal phenotype. PloS ONE. 16(12):e0261730.

W.K. Lau, C.L. Fisher, S. Saini1, A.F. Wise, J. Savige, J.M. Haynes and S.D. Ricardo (2021). Modeling X-linked Alport syndrome with induced pluripotent stem cell-derived podocytes and the reduction of endoplasmic reticulum stress using the chaperone 4-phenylbutryric acid.  Kidney International Reports. DOI: doi: 10.1016/j.ekir.2021.07.027

Milligan-Armstrong, A., Porter, T., Queck H., White A., Haynes, J.M., Jackaman, C., Villemagne, V., Munyard, K., Laws, S., Verdile, G., & Groth, D. (2021). Chronic Stress and Alzheimer’s Disease: The interplay between the Hypothalamic Pituitary Adrenal-axis, genetics and microglia. Biol Rev Camb Philos Soc. 2021 Oct;96(5):2209-2228.  doi: 10.1111/brv.12750. Epub 2021

Tong, Z., Kwak E., Pouton, C.W., Voelcker, N.H., Haynes, J.M. (2021). Long-term 3D maintenance of human forebrain cultures derived from pluripotent stem cells enables robust communication between cell populations in compartmentalized microfluidic chambers Lab Chip: 21(20):4016-4030. doi: 10.1039/d1lc00505g.

Grubman, A., Choo, X.Y., Chew, G., Ouyang, J., Sun, G., Croft, N., Rossello, F., Simmons, R., Buckberry, S., Vargas-Landin, D., Pflueger, J., Vandekolk, T., Abay, Z., Zhou, Y., Liu, X., Chen, J., Larcombe, M., Haynes, J.M., McLean, C., Williams, S., Chai, S., Wilson, T., Lister, R., Pouton, C., Purcell, A., Rackham, O., Petretto, E., & Polo. J. (2021). Transcriptional signature in microglia associated with Aβ plaque phagocytosis. Nat Commun;12(1):3015. doi: 10.1038/s41467-021-23111-1.

Sundaramoorthy, V., Godde, N., Farr, R.J., Green, D., Haynes, J.M., Bingham, J., O’Brien C.M. & Dearnley M. (2020). Modelling lyssavirus infections in stem cell-derived human neuronal cultures.  Viruses;12(4):359. doi: 10.3390/v12040359.

Grubmann, A., Choo, X.Y., Chew, G., Ouyang, J.F., Sun, G., Croft, N.P., Rossello, F.J., Simmons, R., Buckberry, S., Landin, D.V., Pflueger, J., Vandekolk, T.H., Haynes, J.M., Pouton, CW., Polo, J. (2020). A CX3CR1 Reporter hESC Line Facilitates Integrative Analysis of In-Vitro-Derived Microglia and Improved Microglia Identity upon Neuron-Glia Co-culture. Stem Cell Reports;11:S2213-6711(20)30147-8. doi: 10.1016/j.stemcr.2020.04.007.

Murphy, A.R.., Haynes, J.M. Laslett, A., O’Brien, C.M., Cameron, N.R. (2020) Three-dimensional differentiation of human pluripotent stem cell-derived neural precursor cells using tailored porous polymer scaffolds Acta Biomaterialia. 101:102-116. doi: 10.1016/j.actbio.2019.10.017.

Bennett, L.E., Gibbon, A., Gockener, B., Haynes, J.M., Leitner, P., Murray, M., Robinson, A., Williamson, G., Beucking, M. (2019). A new research tool for tracing health impacts of nutrients in foods during processing and digestion. Food Technology. 73(11).

Daniel, P., Filiz, G., Brown, D., Christie, M., Waring, P., Zhang, Y., Haynes, JM., Pouton, CW., Flanagan, D., Vincan, E., Johns, T., Montgomery, M., Phillips, W., Mantamadiotis, T. (2018). PI3K Activation In Neural Stem Cells Drives Tumorigenesis Which Can Be Suppressed By Targeting CREB. Neuro-oncology, 20(10):1344-1355.

Haynes, J.M., Selby, J.N., Vandekolk, T.H., Abad, I.P.L., Ho, J.K., Lieuw, W., Leach, K., Savige, J., Saini, S., Fisher, C.L., Ricardo, S.D.  (2018). Alport syndrome patient derived podocyte-like cells show impaired potassium channel activity. Journal of Pharmacology and Experimental Therapeutics, 367(2):335-347.

Zhu, C., Rodda, A.F., Truong, V.X.  Shi, Y., Zhou, K., Haynes, J.M., Wang, B., Cook, W.D., Forsythe J.S. (2018) Increased cardiomyocyte alignment and intracellular calcium transients using micropatterned and drug-releasing poly(glycerol sebacate) elastomers. ACS Biomaterials Science & Engineering 4(7):2494-2504.

Anderson, D.J., Kaplan, D.I., Bell, K.M., Koutsis, K., Haynes, J.M., Mills, R., Phelan, D., Arasaratnam, D., Qian, E.L., Labonne, T., Ng, E., Davis, R.P., Cassini, S., Hudson, J.E., Porello, E.R., Costa, M.W., Raffii, A., Curl, C.L., Delbridge, L.M., Harvey, R.P., Oshlack, A., Cheung, M.M., Pedersen, R.A., Mummery, C.L., Petrou, S., Elefanty, A.G., Stanley, E.G., & Elliott, D.A. (2018)NKX2-5 regulates human cardiomyogenesis via a HEY2 -dependent transcriptional network.  Nature Communications Apr 10;9(1):1373. doi: 10.1038/s41467-018-03714-x.

Evans, M.A., Lim R., Kim, H.A., Chu H.X., Gardiner-Mann, C.V. Taylor, K.W.E., Chan, C.T., Brait, V.H., Lee, S., Dinh, Q.N., Vinh, A., Phan, T.G., Srikanth, V.K., Arumugam, T.V., Fann, D.Y., Luting, P., Hunt, C.P.J., Pouton, Haynes, J.M., Kwan W., Teo, L., Bourne, J.A, Neumann, S., Young, S., Gowing, E.K., Drummond, G.R., Clarkson, A.N., Wallace, E.M., Sobey, C.G., Broughton B.R.S. (2018). Acute or delayed systemic administration of human amnion epithelial cells improves outcome after stroke.  Stroke. 49(3):700-709. doi: 10.1161/STROKEAHA.117.019136.